Ribose-5-phosphate metabolism protects E. coli from antibiotic lethality

Ribose-5-phosphate metabolism protects E. coli from antibiotic lethality

ABSTRACT In Escherichia coli, ribose-5-phosphate (R5P) biosynthesis occurs via two distinct pathways: an oxidative branch of the pentose phosphate pathway (PPP) originating from glucose-6-phosphate, and a reversed non-oxidative branch originating from fructose-6-phosphate, which relies on transaldol...

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Main Authors: Tatyana Seregina, Rustem Shakulov, Giulio Quarta, Konstantin Shatalin, Svetlana Sklyarova, Irina Petrushanko, Artemy P. Fedulov, Alexander V. Ivanov, Vladimir Mitkevich, Alexander Makarov, Alexander S. Mironov, Evgeny Nudler
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:mBio
Subjects:
Escherichia coli
anabolic pentose phosphate pathway
R5P
oxidative stress
antibiotics
Online Access:https://journals.asm.org/doi/10.1128/mbio.00654-25
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