Anti-Atopic Dermatitis Effect of Seaweed Fulvescens Extract via Inhibiting the STAT1 Pathway
Seaweed fulvescens (SF) is a green alga rich in chlorophyll with unique flavor and taste. It is also called Maesaengi which has antioxidant and other physiological activities. In the present study, we evaluated the therapeutic effects of SF in a mouse model of Dermatophagoides farinae body-induced a...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2019/3760934 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564677148672000 |
|---|---|
| author | Tae-Young Gil Yun-Mi Kang Ye-Jin Eom Chul-Hee Hong Hyo-Jin An |
| author_facet | Tae-Young Gil Yun-Mi Kang Ye-Jin Eom Chul-Hee Hong Hyo-Jin An |
| author_sort | Tae-Young Gil |
| collection | DOAJ |
| description | Seaweed fulvescens (SF) is a green alga rich in chlorophyll with unique flavor and taste. It is also called Maesaengi which has antioxidant and other physiological activities. In the present study, we evaluated the therapeutic effects of SF in a mouse model of Dermatophagoides farinae body-induced atopic dermatitis (AD) and in tumor necrosis factor-α and interferon-γ-stimulated HaCaT keratinocytes. SF treatment (200 mg/mouse) inhibited the development of AD symptoms, compared to that in the control group, as evidenced from the improved dorsal skin lesion, reduced thickness and infiltration of inflammatory cells and smaller lymph nodes, and reduced levels of proinflammatory cytokines. In HaCaT keratinocytes, SF (10, 25, and 50 μg/mL) suppressed the production of proinflammatory cytokines in a dose-dependent manner. In addition, SF reduced the phosphorylation of signal transducer and activator of transcription 1, which is one of the major signaling molecules involved in cellular inflammation. These results suggested that SF could be a potential therapeutic alternative for the treatment of AD. |
| format | Article |
| id | doaj-art-3991006b736f48b589dd8ac1a531d78e |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-3991006b736f48b589dd8ac1a531d78e2025-02-03T01:10:26ZengWileyMediators of Inflammation0962-93511466-18612019-01-01201910.1155/2019/37609343760934Anti-Atopic Dermatitis Effect of Seaweed Fulvescens Extract via Inhibiting the STAT1 PathwayTae-Young Gil0Yun-Mi Kang1Ye-Jin Eom2Chul-Hee Hong3Hyo-Jin An4Department of Pharmacology, College of Korean Medicine, Sangji University, Wonju-si, Gangwon-do 26339, Republic of KoreaDepartment of Pharmacology, College of Korean Medicine, Sangji University, Wonju-si, Gangwon-do 26339, Republic of KoreaDepartment of Korean Medicine Ophthalmology & Otolaryngology & Dermatology, College of Korean Medicine, Sangji University, Wonju-si, Gangwon-do 26339, Republic of KoreaDepartment of Korean Medicine Ophthalmology & Otolaryngology & Dermatology, College of Korean Medicine, Sangji University, Wonju-si, Gangwon-do 26339, Republic of KoreaDepartment of Pharmacology, College of Korean Medicine, Sangji University, Wonju-si, Gangwon-do 26339, Republic of KoreaSeaweed fulvescens (SF) is a green alga rich in chlorophyll with unique flavor and taste. It is also called Maesaengi which has antioxidant and other physiological activities. In the present study, we evaluated the therapeutic effects of SF in a mouse model of Dermatophagoides farinae body-induced atopic dermatitis (AD) and in tumor necrosis factor-α and interferon-γ-stimulated HaCaT keratinocytes. SF treatment (200 mg/mouse) inhibited the development of AD symptoms, compared to that in the control group, as evidenced from the improved dorsal skin lesion, reduced thickness and infiltration of inflammatory cells and smaller lymph nodes, and reduced levels of proinflammatory cytokines. In HaCaT keratinocytes, SF (10, 25, and 50 μg/mL) suppressed the production of proinflammatory cytokines in a dose-dependent manner. In addition, SF reduced the phosphorylation of signal transducer and activator of transcription 1, which is one of the major signaling molecules involved in cellular inflammation. These results suggested that SF could be a potential therapeutic alternative for the treatment of AD.http://dx.doi.org/10.1155/2019/3760934 |
| spellingShingle | Tae-Young Gil Yun-Mi Kang Ye-Jin Eom Chul-Hee Hong Hyo-Jin An Anti-Atopic Dermatitis Effect of Seaweed Fulvescens Extract via Inhibiting the STAT1 Pathway Mediators of Inflammation |
| title | Anti-Atopic Dermatitis Effect of Seaweed Fulvescens Extract via Inhibiting the STAT1 Pathway |
| title_full | Anti-Atopic Dermatitis Effect of Seaweed Fulvescens Extract via Inhibiting the STAT1 Pathway |
| title_fullStr | Anti-Atopic Dermatitis Effect of Seaweed Fulvescens Extract via Inhibiting the STAT1 Pathway |
| title_full_unstemmed | Anti-Atopic Dermatitis Effect of Seaweed Fulvescens Extract via Inhibiting the STAT1 Pathway |
| title_short | Anti-Atopic Dermatitis Effect of Seaweed Fulvescens Extract via Inhibiting the STAT1 Pathway |
| title_sort | anti atopic dermatitis effect of seaweed fulvescens extract via inhibiting the stat1 pathway |
| url | http://dx.doi.org/10.1155/2019/3760934 |
| work_keys_str_mv | AT taeyounggil antiatopicdermatitiseffectofseaweedfulvescensextractviainhibitingthestat1pathway AT yunmikang antiatopicdermatitiseffectofseaweedfulvescensextractviainhibitingthestat1pathway AT yejineom antiatopicdermatitiseffectofseaweedfulvescensextractviainhibitingthestat1pathway AT chulheehong antiatopicdermatitiseffectofseaweedfulvescensextractviainhibitingthestat1pathway AT hyojinan antiatopicdermatitiseffectofseaweedfulvescensextractviainhibitingthestat1pathway |