Breathable core–shell microneedle patches for diabetic wound treatment
Microneedles have demonstrated valuable applications in diabetic wound management. Many endeavors are devoted to developing microneedles with well-designed structures and enhanced functions. Herein, we present an elaborate microneedle patch with breathability for wound healing by a multi-step replic...
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| Format: | Article |
| Language: | English |
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IOP Publishing
2025-01-01
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| Series: | Materials Futures |
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| Online Access: | https://doi.org/10.1088/2752-5724/adcbc6 |
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| author | Lu Fan Yu Wang Li Wang Xiang Lin Xiaoju Wang Luoran Shang Hongbo Zhang Yuanjin Zhao |
| author_facet | Lu Fan Yu Wang Li Wang Xiang Lin Xiaoju Wang Luoran Shang Hongbo Zhang Yuanjin Zhao |
| author_sort | Lu Fan |
| collection | DOAJ |
| description | Microneedles have demonstrated valuable applications in diabetic wound management. Many endeavors are devoted to developing microneedles with well-designed structures and enhanced functions. Herein, we present an elaborate microneedle patch with breathability for wound healing by a multi-step replication method. The microneedle patch consists of a breathable porous supporting substrate and core–shell tips involving poly (vinyl alcohol) shells loaded with antimicrobial peptides (PVA@AMPs shell) and crosslinked Gelma cores encapsulated with exosomes (Gelma@exo core). The PVA was crosslinked with a ROS-responsive linker, which results in degradation of the microneedle shell in the inflammatory microenvironment, thus inducing the release of loaded AMPs to inhibit bacteria. Further, the exosomes continuously release from the exposed Gelma@exo core, promoting tissue regeneration and regulating the immune response. Besides, the high porosity of the supporting substrate makes the microneedle patches more suitable for chronic wounds. Based on these features, it was demonstrated that the microneedle patch exhibits desirable performance in in vivo animal tests. Thus, we believe that the proposed microneedle patches have remarkable potential in wound healing and related fields. |
| format | Article |
| id | doaj-art-398eb73f68e34aba98091223c694dcad |
| institution | OA Journals |
| issn | 2752-5724 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | Materials Futures |
| spelling | doaj-art-398eb73f68e34aba98091223c694dcad2025-08-20T02:24:58ZengIOP PublishingMaterials Futures2752-57242025-01-014202540210.1088/2752-5724/adcbc6Breathable core–shell microneedle patches for diabetic wound treatmentLu Fan0https://orcid.org/0009-0004-2553-8525Yu Wang1Li Wang2Xiang Lin3Xiaoju Wang4Luoran Shang5Hongbo Zhang6https://orcid.org/0000-0002-1071-4416Yuanjin Zhao7Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University , Nanjing 210096, People’s Republic of China; Pharmaceutical Sciences Laboratory, Åbo Akademi University , Turku 20520, FinlandDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University , Nanjing 210096, People’s Republic of ChinaPharmaceutical Sciences Laboratory, Åbo Akademi University , Turku 20520, FinlandPharmaceutical Sciences Laboratory, Åbo Akademi University , Turku 20520, FinlandPharmaceutical Sciences Laboratory, Åbo Akademi University , Turku 20520, FinlandShanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, and the Shanghai Key Laboratory of Medical Epigenetics, The International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University , Shanghai 200032, People’s Republic of ChinaPharmaceutical Sciences Laboratory, Åbo Akademi University , Turku 20520, Finland; Turku Bioscience Centre, University of Turku and Åbo Akademi University , Turku 20520, FinlandDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University , Nanjing 210096, People’s Republic of China; Wenzhou Institute, University of Chinese Academy of Sciences , Wenzhou, Zhejiang 325001, People’s Republic of ChinaMicroneedles have demonstrated valuable applications in diabetic wound management. Many endeavors are devoted to developing microneedles with well-designed structures and enhanced functions. Herein, we present an elaborate microneedle patch with breathability for wound healing by a multi-step replication method. The microneedle patch consists of a breathable porous supporting substrate and core–shell tips involving poly (vinyl alcohol) shells loaded with antimicrobial peptides (PVA@AMPs shell) and crosslinked Gelma cores encapsulated with exosomes (Gelma@exo core). The PVA was crosslinked with a ROS-responsive linker, which results in degradation of the microneedle shell in the inflammatory microenvironment, thus inducing the release of loaded AMPs to inhibit bacteria. Further, the exosomes continuously release from the exposed Gelma@exo core, promoting tissue regeneration and regulating the immune response. Besides, the high porosity of the supporting substrate makes the microneedle patches more suitable for chronic wounds. Based on these features, it was demonstrated that the microneedle patch exhibits desirable performance in in vivo animal tests. Thus, we believe that the proposed microneedle patches have remarkable potential in wound healing and related fields.https://doi.org/10.1088/2752-5724/adcbc6breathablemicroneedlehydrogelexosomediabetic wound |
| spellingShingle | Lu Fan Yu Wang Li Wang Xiang Lin Xiaoju Wang Luoran Shang Hongbo Zhang Yuanjin Zhao Breathable core–shell microneedle patches for diabetic wound treatment Materials Futures breathable microneedle hydrogel exosome diabetic wound |
| title | Breathable core–shell microneedle patches for diabetic wound treatment |
| title_full | Breathable core–shell microneedle patches for diabetic wound treatment |
| title_fullStr | Breathable core–shell microneedle patches for diabetic wound treatment |
| title_full_unstemmed | Breathable core–shell microneedle patches for diabetic wound treatment |
| title_short | Breathable core–shell microneedle patches for diabetic wound treatment |
| title_sort | breathable core shell microneedle patches for diabetic wound treatment |
| topic | breathable microneedle hydrogel exosome diabetic wound |
| url | https://doi.org/10.1088/2752-5724/adcbc6 |
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