Infusion line contamination in preterm neonates: impact of infusion line design, length, and use duration: the multicenter ChronoBIOline study
IntroductionCentral venous catheters are critical in preterm neonatal care but increase the risk of central line-associated bloodstream infections (CLABSIs). The incidence of S. haemolyticus-associated CLABSIs in French neonates is increasing, but the mechanisms underlying this trend remain unclear....
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2025-01-01
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| author | Sandra Dos Santos Anne-Sophie Valentin Mathilde Farizon Manon Charbonneau Mohamed Riadh Boukhris Roselyne Brat Fabiana Cazzorla Jennifer Chauvel Fabrice Cneude Pauline Coutable Maryvonne Demasure Emeline Duminil Vénonique Faraut-Derouin Maud Gits Muselli Valérie Gorin Rosemary Goujon Melinda Guillouche-Puissant Nadine Hacinlioglu Caroline Landelle Annick Lefebvre Elise Leroy-Terquem Aurore Martinet Camille Massebeuf Nadia Mazille Orfanos Guillaume Menard Laure Menvielle Vanessa Monin Virginie Morange Juliana Patkai Nathalie Perrault Emilie Prat Nathalie van der Mee-Marquet |
| author_facet | Sandra Dos Santos Anne-Sophie Valentin Mathilde Farizon Manon Charbonneau Mohamed Riadh Boukhris Roselyne Brat Fabiana Cazzorla Jennifer Chauvel Fabrice Cneude Pauline Coutable Maryvonne Demasure Emeline Duminil Vénonique Faraut-Derouin Maud Gits Muselli Valérie Gorin Rosemary Goujon Melinda Guillouche-Puissant Nadine Hacinlioglu Caroline Landelle Annick Lefebvre Elise Leroy-Terquem Aurore Martinet Camille Massebeuf Nadia Mazille Orfanos Guillaume Menard Laure Menvielle Vanessa Monin Virginie Morange Juliana Patkai Nathalie Perrault Emilie Prat Nathalie van der Mee-Marquet |
| author_sort | Sandra Dos Santos |
| collection | DOAJ |
| description | IntroductionCentral venous catheters are critical in preterm neonatal care but increase the risk of central line-associated bloodstream infections (CLABSIs). The incidence of S. haemolyticus-associated CLABSIs in French neonates is increasing, but the mechanisms underlying this trend remain unclear.MethodsWe examined microorganisms in 108 central line infusion sets used in preterm infants across 12 neonatal intensive care units, and collected at the time of removal.ResultsThe infusion sets varied widely in type (28 types; 1-6 parts) and length (10-180 cm, mean 52.9 cm). Contamination was detected in 24 infusion sets (22.2%), mainly by coagulase-negative Staphylococci (50.0%) and Bacillus species (41.7%). Higher contamination rates were linked to longer infusion lines (> 50 cm; p < 0.001), usage beyond 7 days (p = 0.002), and multi-line infusion systems (p < 0.001).DiscussionOur findings are fully consistent with guidelines, which recommend simpler designs and a 4 or 7-day use of infusion sets, emphasizing the importance of adhering to these guidelines to reduce the risk of CLABSIs. Additionally, our findings raise concerns regarding the use of multi-line infusion systems. These devices, which combine extended infusion line length, manufacturer-authorized use of up to 21 days, and intermittent use of certain infusion lines, are easily contaminated during use, creating a high-risk situation for central line contamination. |
| format | Article |
| id | doaj-art-398ea2e646284fd599db0eff5a96e158 |
| institution | Kabale University |
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| spelling | doaj-art-398ea2e646284fd599db0eff5a96e1582025-01-24T07:13:31ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-01-011510.3389/fmicb.2024.14955681495568Infusion line contamination in preterm neonates: impact of infusion line design, length, and use duration: the multicenter ChronoBIOline studySandra Dos Santos0Anne-Sophie Valentin1Mathilde Farizon2Manon Charbonneau3Mohamed Riadh Boukhris4Roselyne Brat5Fabiana Cazzorla6Jennifer Chauvel7Fabrice Cneude8Pauline Coutable9Maryvonne Demasure10Emeline Duminil11Vénonique Faraut-Derouin12Maud Gits Muselli13Valérie Gorin14Rosemary Goujon15Melinda Guillouche-Puissant16Nadine Hacinlioglu17Caroline Landelle18Annick Lefebvre19Elise Leroy-Terquem20Aurore Martinet21Camille Massebeuf22Nadia Mazille Orfanos23Guillaume Menard24Laure Menvielle25Vanessa Monin26Virginie Morange27Juliana Patkai28Nathalie Perrault29Emilie Prat30Nathalie van der Mee-Marquet31Centre Hospitalier Régional Universitaire, Hôpital Bretonneau, Mission Nationale Surveillance et Prévention des Infections Associées aux Dispositifs Invasifs, Centre d’Appui pour la Prévention des Infections Associées aux Soins en Région Centre val de Loire, Tours, FranceCentre Hospitalier Régional Universitaire, Hôpital Bretonneau, Mission Nationale Surveillance et Prévention des Infections Associées aux Dispositifs Invasifs, Centre d’Appui pour la Prévention des Infections Associées aux Soins en Région Centre val de Loire, Tours, FranceCentre Hospitalier Régional Universitaire, Hôpital Bretonneau, Mission Nationale Surveillance et Prévention des Infections Associées aux Dispositifs Invasifs, Centre d’Appui pour la Prévention des Infections Associées aux Soins en Région Centre val de Loire, Tours, FranceCentre Hospitalier Régional Universitaire, Hôpital Bretonneau, Mission Nationale Surveillance et Prévention des Infections Associées aux Dispositifs Invasifs, Centre d’Appui pour la Prévention des Infections Associées aux Soins en Région Centre val de Loire, Tours, FranceCentre Hospitalier Universitaire, Service de Réanimation Néonatale, Lille, FranceCentre Hospitalier Universitaire, Service de Réanimation Néonatale, Orléans, FranceHospital Hygiene Unit, Centre Hospitalier Universitaire Grenoble Alpes, Université Grenoble Alpes, CNRS, Grenoble INP, TIMC, Grenoble, FranceService de Néonatalogie, Centre Hospitalier, Saint Brieuc, FranceNeonatal Intensive Care Unit, Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, FranceService de Réanimation Néonatale, Centre Hospitalier Régional Universitaire, Tours, FranceService de Prévention du Risque Infectieux, Centre Hospitalier Universitaire, Orléans, FranceEquipe Opérationnelle d’Hygiène, Centre Hospitalier, Calais, France0Equipe Opérationnelle d’Hygiène, Assistance Publique – Hôpitaux de Paris, Hôpital Cochin, Paris, France1Equipe Opérationnelle d’Hygiène, Assistance Publique – Hôpitaux de Paris, Hôpital Robert Debré, Paris, FranceService de Prévention du Risque Infectieux, Centre Hospitalier Universitaire, Orléans, FranceService de Néonatalogie, Centre Hospitalier, Saint Brieuc, France2Service de Réanimation Néonatale, Hôpital Sud, Centre Hospitalier Universitaire, Rennes, France2Service de Réanimation Néonatale, Hôpital Sud, Centre Hospitalier Universitaire, Rennes, FranceHospital Hygiene Unit, Centre Hospitalier Universitaire Grenoble Alpes, Université Grenoble Alpes, CNRS, Grenoble INP, TIMC, Grenoble, France3Equipe Opérationnelle d’Hygiène, Centre Hospitalier Régional Universitaire, Reims, France4Service de Réanimation Néonatale, Assistance Publique – Hôpitaux de Paris, Hôpital Necker, Paris, FranceCentre Hospitalier Universitaire, Service de Réanimation Néonatale, Orléans, FranceHospital Hygiene Unit, Centre Hospitalier Universitaire Grenoble Alpes, Université Grenoble Alpes, CNRS, Grenoble INP, TIMC, Grenoble, France2Service de Réanimation Néonatale, Hôpital Sud, Centre Hospitalier Universitaire, Rennes, France5Service de Bactériologie Hygiène-Hospitalière, UMR_S 1230, Centre Hospitalier Universitaire, Rennes, France6Service de Reanimation Néonatale et Pédiatrique, Centre Hospitalier Régional Universitaire, Reims, France7Service de Réanimation Néonatale, Assistance Publique – Hôpitaux de Paris, Hôpital Béclère, Clamart, France8Equipe Opérationnelle d’Hygiène, Centre Hospitalier Régional Universitaire, Tours, France9Service de Reanimation Néonatale, Assistance Publique – Hôpitaux de Paris, Hôpital Port-Royal, Paris, France0Service de Réanimation Néonatale, Assistance Publique – Hôpitaux de Paris, Hôpital Cochin, Paris, France1Unité de Prévention et de Contrôle de l’Infection, Centre Hospitalier, Saint Brieuc, FranceCentre Hospitalier Régional Universitaire, Hôpital Bretonneau, Mission Nationale Surveillance et Prévention des Infections Associées aux Dispositifs Invasifs, Centre d’Appui pour la Prévention des Infections Associées aux Soins en Région Centre val de Loire, Tours, FranceIntroductionCentral venous catheters are critical in preterm neonatal care but increase the risk of central line-associated bloodstream infections (CLABSIs). The incidence of S. haemolyticus-associated CLABSIs in French neonates is increasing, but the mechanisms underlying this trend remain unclear.MethodsWe examined microorganisms in 108 central line infusion sets used in preterm infants across 12 neonatal intensive care units, and collected at the time of removal.ResultsThe infusion sets varied widely in type (28 types; 1-6 parts) and length (10-180 cm, mean 52.9 cm). Contamination was detected in 24 infusion sets (22.2%), mainly by coagulase-negative Staphylococci (50.0%) and Bacillus species (41.7%). Higher contamination rates were linked to longer infusion lines (> 50 cm; p < 0.001), usage beyond 7 days (p = 0.002), and multi-line infusion systems (p < 0.001).DiscussionOur findings are fully consistent with guidelines, which recommend simpler designs and a 4 or 7-day use of infusion sets, emphasizing the importance of adhering to these guidelines to reduce the risk of CLABSIs. Additionally, our findings raise concerns regarding the use of multi-line infusion systems. These devices, which combine extended infusion line length, manufacturer-authorized use of up to 21 days, and intermittent use of certain infusion lines, are easily contaminated during use, creating a high-risk situation for central line contamination.https://www.frontiersin.org/articles/10.3389/fmicb.2024.1495568/fullneonatalogyinfusion linecentral line associated bacteremiacentral venous catheterumbilical catheterperipherally inserted central catheter |
| spellingShingle | Sandra Dos Santos Anne-Sophie Valentin Mathilde Farizon Manon Charbonneau Mohamed Riadh Boukhris Roselyne Brat Fabiana Cazzorla Jennifer Chauvel Fabrice Cneude Pauline Coutable Maryvonne Demasure Emeline Duminil Vénonique Faraut-Derouin Maud Gits Muselli Valérie Gorin Rosemary Goujon Melinda Guillouche-Puissant Nadine Hacinlioglu Caroline Landelle Annick Lefebvre Elise Leroy-Terquem Aurore Martinet Camille Massebeuf Nadia Mazille Orfanos Guillaume Menard Laure Menvielle Vanessa Monin Virginie Morange Juliana Patkai Nathalie Perrault Emilie Prat Nathalie van der Mee-Marquet Infusion line contamination in preterm neonates: impact of infusion line design, length, and use duration: the multicenter ChronoBIOline study Frontiers in Microbiology neonatalogy infusion line central line associated bacteremia central venous catheter umbilical catheter peripherally inserted central catheter |
| title | Infusion line contamination in preterm neonates: impact of infusion line design, length, and use duration: the multicenter ChronoBIOline study |
| title_full | Infusion line contamination in preterm neonates: impact of infusion line design, length, and use duration: the multicenter ChronoBIOline study |
| title_fullStr | Infusion line contamination in preterm neonates: impact of infusion line design, length, and use duration: the multicenter ChronoBIOline study |
| title_full_unstemmed | Infusion line contamination in preterm neonates: impact of infusion line design, length, and use duration: the multicenter ChronoBIOline study |
| title_short | Infusion line contamination in preterm neonates: impact of infusion line design, length, and use duration: the multicenter ChronoBIOline study |
| title_sort | infusion line contamination in preterm neonates impact of infusion line design length and use duration the multicenter chronobioline study |
| topic | neonatalogy infusion line central line associated bacteremia central venous catheter umbilical catheter peripherally inserted central catheter |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1495568/full |
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