APT imaging of hepatocellular carcinoma signals an effective therapeutic response in advance of tumor shrinkage
Aim: The aim of this study was to assess the utility of weighted amide proton transfer (APTw) MRI in three different rodent models of hepatocellular carcinoma (HCC).Methods: APTw MRI was evaluated in models of diethylnitrosamine (DEN) induced HCC, N1S1 syngeneic orthotopic xenograft and human HepG2...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis
2024-12-01
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| Series: | Hepatic Oncology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/20450923.2024.2389031 |
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| _version_ | 1832581945010159616 |
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| author | Xiaojing Wang Keisuke Ishimatsu Junjie Li Xiaodong Wen Weijun Ou Arnida Anwar Jaideep Chaudhary Masaya Takahashi A Dean Sherry Ian R Corbin |
| author_facet | Xiaojing Wang Keisuke Ishimatsu Junjie Li Xiaodong Wen Weijun Ou Arnida Anwar Jaideep Chaudhary Masaya Takahashi A Dean Sherry Ian R Corbin |
| author_sort | Xiaojing Wang |
| collection | DOAJ |
| description | Aim: The aim of this study was to assess the utility of weighted amide proton transfer (APTw) MRI in three different rodent models of hepatocellular carcinoma (HCC).Methods: APTw MRI was evaluated in models of diethylnitrosamine (DEN) induced HCC, N1S1 syngeneic orthotopic xenograft and human HepG2 ectopic xenograft.Results: All models of HCC showed a higher APTw signal over the surrounding normal tissues. In the DEN model, the APTw signal could differentiate HCC lesions from benign nodules. Intra-arterial administration of low-density lipoprotein docosahexaenoic acid (LDL-DHA) nanoparticles to N1S1 xenografts rapidly lowered the tumor APTw signal within 72 h. Direct injections of LDL-DHA nanoparticles into HepG2 xenografts also showed similar therapeutic responses.Conclusion: We have demonstrated the utility of APTw imaging in the diagnostic/therapeutic management of HCC. |
| format | Article |
| id | doaj-art-398cbb479cd0478e8a4bf543065b03bd |
| institution | Kabale University |
| issn | 2045-0923 2045-0931 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis |
| record_format | Article |
| series | Hepatic Oncology |
| spelling | doaj-art-398cbb479cd0478e8a4bf543065b03bd2025-01-30T06:49:33ZengTaylor & FrancisHepatic Oncology2045-09232045-09312024-12-0111110.1080/20450923.2024.2389031APT imaging of hepatocellular carcinoma signals an effective therapeutic response in advance of tumor shrinkageXiaojing Wang0Keisuke Ishimatsu1Junjie Li2Xiaodong Wen3Weijun Ou4Arnida Anwar5Jaideep Chaudhary6Masaya Takahashi7A Dean Sherry8Ian R Corbin9Advanced Imaging Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USAAdvanced Imaging Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USAAdvanced Imaging Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USAAdvanced Imaging Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USAAdvanced Imaging Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USAAdvanced Imaging Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USAAdvanced Imaging Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USAAdvanced Imaging Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USAAdvanced Imaging Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USAAdvanced Imaging Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USAAim: The aim of this study was to assess the utility of weighted amide proton transfer (APTw) MRI in three different rodent models of hepatocellular carcinoma (HCC).Methods: APTw MRI was evaluated in models of diethylnitrosamine (DEN) induced HCC, N1S1 syngeneic orthotopic xenograft and human HepG2 ectopic xenograft.Results: All models of HCC showed a higher APTw signal over the surrounding normal tissues. In the DEN model, the APTw signal could differentiate HCC lesions from benign nodules. Intra-arterial administration of low-density lipoprotein docosahexaenoic acid (LDL-DHA) nanoparticles to N1S1 xenografts rapidly lowered the tumor APTw signal within 72 h. Direct injections of LDL-DHA nanoparticles into HepG2 xenografts also showed similar therapeutic responses.Conclusion: We have demonstrated the utility of APTw imaging in the diagnostic/therapeutic management of HCC.https://www.tandfonline.com/doi/10.1080/20450923.2024.2389031docosahexaenoic acidhepatocellular carcinomalow-density lipoproteinmolecular imagingnanoparticle |
| spellingShingle | Xiaojing Wang Keisuke Ishimatsu Junjie Li Xiaodong Wen Weijun Ou Arnida Anwar Jaideep Chaudhary Masaya Takahashi A Dean Sherry Ian R Corbin APT imaging of hepatocellular carcinoma signals an effective therapeutic response in advance of tumor shrinkage Hepatic Oncology docosahexaenoic acid hepatocellular carcinoma low-density lipoprotein molecular imaging nanoparticle |
| title | APT imaging of hepatocellular carcinoma signals an effective therapeutic response in advance of tumor shrinkage |
| title_full | APT imaging of hepatocellular carcinoma signals an effective therapeutic response in advance of tumor shrinkage |
| title_fullStr | APT imaging of hepatocellular carcinoma signals an effective therapeutic response in advance of tumor shrinkage |
| title_full_unstemmed | APT imaging of hepatocellular carcinoma signals an effective therapeutic response in advance of tumor shrinkage |
| title_short | APT imaging of hepatocellular carcinoma signals an effective therapeutic response in advance of tumor shrinkage |
| title_sort | apt imaging of hepatocellular carcinoma signals an effective therapeutic response in advance of tumor shrinkage |
| topic | docosahexaenoic acid hepatocellular carcinoma low-density lipoprotein molecular imaging nanoparticle |
| url | https://www.tandfonline.com/doi/10.1080/20450923.2024.2389031 |
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