Effects of Antisense Oligonucleotides against C-Reactive Protein on the Development of Atherosclerosis in WHHL Rabbits
Increased plasma levels of C-reactive protein (CRP) are closely associated with cardiovascular diseases, but whether CRP is directly involved in the pathogenesis of atherosclerosis is still under debate. Many controversial and contradictory results using transgenic mice and rabbits have been publish...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/979132 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549431085367296 |
|---|---|
| author | Qi Yu Zhengcao Liu Ahmed Bilal Waqar Bo Ning Xianghong Yang Masashi Shiomi Mark J. Graham Rosanne M. Crooke Enqi Liu Sijun Dong Jianglin Fan |
| author_facet | Qi Yu Zhengcao Liu Ahmed Bilal Waqar Bo Ning Xianghong Yang Masashi Shiomi Mark J. Graham Rosanne M. Crooke Enqi Liu Sijun Dong Jianglin Fan |
| author_sort | Qi Yu |
| collection | DOAJ |
| description | Increased plasma levels of C-reactive protein (CRP) are closely associated with cardiovascular diseases, but whether CRP is directly involved in the pathogenesis of atherosclerosis is still under debate. Many controversial and contradictory results using transgenic mice and rabbits have been published but it is also unclear whether CRP lowering can be used for the treatment of atherosclerosis. In the current study, we examined the effects of the rabbit CRP antisense oligonucleotides (ASO) on the development of atherosclerosis in WHHL rabbits. CRP ASO treatment led to a significant reduction of plasma CRP levels; however, both aortic and coronary atherosclerotic lesions were not significantly changed compared to those of control WHHL rabbits. These results suggest that inhibition of plasma CRP does not affect the development of atherosclerosis in WHHL rabbits. |
| format | Article |
| id | doaj-art-398a499d418342dbba315b876c511911 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-398a499d418342dbba315b876c5119112025-02-03T06:11:20ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/979132979132Effects of Antisense Oligonucleotides against C-Reactive Protein on the Development of Atherosclerosis in WHHL RabbitsQi Yu0Zhengcao Liu1Ahmed Bilal Waqar2Bo Ning3Xianghong Yang4Masashi Shiomi5Mark J. Graham6Rosanne M. Crooke7Enqi Liu8Sijun Dong9Jianglin Fan10Department of Molecular Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Chuo-City 409-3898, JapanDepartment of Molecular Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Chuo-City 409-3898, JapanDepartment of Molecular Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Chuo-City 409-3898, JapanDepartment of Molecular Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Chuo-City 409-3898, JapanDepartment of Pathology, Shengjing Hospital of China Medical University, Shenyang 110003, ChinaExperimental Animal Center and Animal Models for Cardiovascular Diseases, Kobe University School of Medicine, Kobe 6500017, JapanIsis Pharmaceuticals Inc., Carlsbad, CA 92008, USAIsis Pharmaceuticals Inc., Carlsbad, CA 92008, USAResearch Institute of Atherosclerotic Disease and Laboratory Animal Center, Xi'an Jiaotong University School of Medicine, Xi'an 710061, ChinaKey Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, ChinaDepartment of Molecular Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Chuo-City 409-3898, JapanIncreased plasma levels of C-reactive protein (CRP) are closely associated with cardiovascular diseases, but whether CRP is directly involved in the pathogenesis of atherosclerosis is still under debate. Many controversial and contradictory results using transgenic mice and rabbits have been published but it is also unclear whether CRP lowering can be used for the treatment of atherosclerosis. In the current study, we examined the effects of the rabbit CRP antisense oligonucleotides (ASO) on the development of atherosclerosis in WHHL rabbits. CRP ASO treatment led to a significant reduction of plasma CRP levels; however, both aortic and coronary atherosclerotic lesions were not significantly changed compared to those of control WHHL rabbits. These results suggest that inhibition of plasma CRP does not affect the development of atherosclerosis in WHHL rabbits.http://dx.doi.org/10.1155/2014/979132 |
| spellingShingle | Qi Yu Zhengcao Liu Ahmed Bilal Waqar Bo Ning Xianghong Yang Masashi Shiomi Mark J. Graham Rosanne M. Crooke Enqi Liu Sijun Dong Jianglin Fan Effects of Antisense Oligonucleotides against C-Reactive Protein on the Development of Atherosclerosis in WHHL Rabbits Mediators of Inflammation |
| title | Effects of Antisense Oligonucleotides against C-Reactive Protein on the Development of Atherosclerosis in WHHL Rabbits |
| title_full | Effects of Antisense Oligonucleotides against C-Reactive Protein on the Development of Atherosclerosis in WHHL Rabbits |
| title_fullStr | Effects of Antisense Oligonucleotides against C-Reactive Protein on the Development of Atherosclerosis in WHHL Rabbits |
| title_full_unstemmed | Effects of Antisense Oligonucleotides against C-Reactive Protein on the Development of Atherosclerosis in WHHL Rabbits |
| title_short | Effects of Antisense Oligonucleotides against C-Reactive Protein on the Development of Atherosclerosis in WHHL Rabbits |
| title_sort | effects of antisense oligonucleotides against c reactive protein on the development of atherosclerosis in whhl rabbits |
| url | http://dx.doi.org/10.1155/2014/979132 |
| work_keys_str_mv | AT qiyu effectsofantisenseoligonucleotidesagainstcreactiveproteinonthedevelopmentofatherosclerosisinwhhlrabbits AT zhengcaoliu effectsofantisenseoligonucleotidesagainstcreactiveproteinonthedevelopmentofatherosclerosisinwhhlrabbits AT ahmedbilalwaqar effectsofantisenseoligonucleotidesagainstcreactiveproteinonthedevelopmentofatherosclerosisinwhhlrabbits AT boning effectsofantisenseoligonucleotidesagainstcreactiveproteinonthedevelopmentofatherosclerosisinwhhlrabbits AT xianghongyang effectsofantisenseoligonucleotidesagainstcreactiveproteinonthedevelopmentofatherosclerosisinwhhlrabbits AT masashishiomi effectsofantisenseoligonucleotidesagainstcreactiveproteinonthedevelopmentofatherosclerosisinwhhlrabbits AT markjgraham effectsofantisenseoligonucleotidesagainstcreactiveproteinonthedevelopmentofatherosclerosisinwhhlrabbits AT rosannemcrooke effectsofantisenseoligonucleotidesagainstcreactiveproteinonthedevelopmentofatherosclerosisinwhhlrabbits AT enqiliu effectsofantisenseoligonucleotidesagainstcreactiveproteinonthedevelopmentofatherosclerosisinwhhlrabbits AT sijundong effectsofantisenseoligonucleotidesagainstcreactiveproteinonthedevelopmentofatherosclerosisinwhhlrabbits AT jianglinfan effectsofantisenseoligonucleotidesagainstcreactiveproteinonthedevelopmentofatherosclerosisinwhhlrabbits |