Oxidative stress in hydrocephalus: A new potential therapeutic target
Abstract Hydrocephalus is an abnormal accumulation of cerebrospinal fluid within the skull for several reasons, such as cerebrospinal fluid overproduction, circulatory obstruction, and malabsorption. Excess fluid causes the ventricular system and subarachnoid space to enlarge due to the squeezing of...
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | Brain-X |
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| Online Access: | https://doi.org/10.1002/brx2.70008 |
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| author | Jie Zhao Zhi Tang Yuchu Jiang Yijian Yang Junbo Liao Zhangjie Su Ahsan Muhammad Usman Xiaoyu Chen Gelei Xiao |
| author_facet | Jie Zhao Zhi Tang Yuchu Jiang Yijian Yang Junbo Liao Zhangjie Su Ahsan Muhammad Usman Xiaoyu Chen Gelei Xiao |
| author_sort | Jie Zhao |
| collection | DOAJ |
| description | Abstract Hydrocephalus is an abnormal accumulation of cerebrospinal fluid within the skull for several reasons, such as cerebrospinal fluid overproduction, circulatory obstruction, and malabsorption. Excess fluid causes the ventricular system and subarachnoid space to enlarge due to the squeezing of cerebrospinal fluid. Hydrocephalus is clinically manifested by increased intracranial pressure and impaired brain function. It is a neurological disease with a variety of complications that affect the body and require long‐term and continuous treatment; however, current treatment methods are relatively limited, whether medical or surgical. Studies have shown that oxidative stress plays an important role in the formation and development of hydrocephalus, but it has not been systematically reviewed in current studies. In this paper, oxidative stress in hydrocephalus formation and its potential role were systematically reviewed, including the mechanism of oxidative stress, related signaling pathways, and pathological changes in oxidative stress formation. The purpose of this paper is to illustrate the possibility of oxidative stress as a new therapeutic target of hydrocephalus treatment, expecting that it will be helpful for future research. |
| format | Article |
| id | doaj-art-39828bfb7578423eacfef62220677713 |
| institution | DOAJ |
| issn | 2835-3153 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain-X |
| spelling | doaj-art-39828bfb7578423eacfef622206777132025-08-20T02:58:25ZengWileyBrain-X2835-31532024-12-0124n/an/a10.1002/brx2.70008Oxidative stress in hydrocephalus: A new potential therapeutic targetJie Zhao0Zhi Tang1Yuchu Jiang2Yijian Yang3Junbo Liao4Zhangjie Su5Ahsan Muhammad Usman6Xiaoyu Chen7Gelei Xiao8Department of Neurosurgery Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Changsha Hunan ChinaDepartment of Neurosurgery Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Changsha Hunan ChinaDepartment of Neurosurgery Xiangya Hospital Central South University Changsha Hunan ChinaDepartment of Neurosurgery Xiangya Hospital Central South University Changsha Hunan ChinaDepartment of Neurosurgery Xiangya Hospital Central South University Changsha Hunan ChinaDepartment of Neurosurgery Addenbrooke's Hospital Cambridge University Hospitals NHS Foundation Trust Cambridge UKDepartment of Neurosurgery Allied Hospital Faisalabad Faisalabad PakistanDepartment of Neurosurgery Xiangya Hospital Central South University Changsha Hunan ChinaDepartment of Neurosurgery Xiangya Hospital Central South University Changsha Hunan ChinaAbstract Hydrocephalus is an abnormal accumulation of cerebrospinal fluid within the skull for several reasons, such as cerebrospinal fluid overproduction, circulatory obstruction, and malabsorption. Excess fluid causes the ventricular system and subarachnoid space to enlarge due to the squeezing of cerebrospinal fluid. Hydrocephalus is clinically manifested by increased intracranial pressure and impaired brain function. It is a neurological disease with a variety of complications that affect the body and require long‐term and continuous treatment; however, current treatment methods are relatively limited, whether medical or surgical. Studies have shown that oxidative stress plays an important role in the formation and development of hydrocephalus, but it has not been systematically reviewed in current studies. In this paper, oxidative stress in hydrocephalus formation and its potential role were systematically reviewed, including the mechanism of oxidative stress, related signaling pathways, and pathological changes in oxidative stress formation. The purpose of this paper is to illustrate the possibility of oxidative stress as a new therapeutic target of hydrocephalus treatment, expecting that it will be helpful for future research.https://doi.org/10.1002/brx2.70008active oxideantioxidant therapyhydrocephalusinflammatoryischemic injurytherapeutic target |
| spellingShingle | Jie Zhao Zhi Tang Yuchu Jiang Yijian Yang Junbo Liao Zhangjie Su Ahsan Muhammad Usman Xiaoyu Chen Gelei Xiao Oxidative stress in hydrocephalus: A new potential therapeutic target Brain-X active oxide antioxidant therapy hydrocephalus inflammatory ischemic injury therapeutic target |
| title | Oxidative stress in hydrocephalus: A new potential therapeutic target |
| title_full | Oxidative stress in hydrocephalus: A new potential therapeutic target |
| title_fullStr | Oxidative stress in hydrocephalus: A new potential therapeutic target |
| title_full_unstemmed | Oxidative stress in hydrocephalus: A new potential therapeutic target |
| title_short | Oxidative stress in hydrocephalus: A new potential therapeutic target |
| title_sort | oxidative stress in hydrocephalus a new potential therapeutic target |
| topic | active oxide antioxidant therapy hydrocephalus inflammatory ischemic injury therapeutic target |
| url | https://doi.org/10.1002/brx2.70008 |
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