Pregnancy and Acute Lymphoblastic Leukemia: A Case Series and Review of Literature
Acute lymphoblastic leukemia (ALL) diagnosed during pregnancy is rare and causes ethical and therapeutic challenges. We performed a retrospective search of ALL patients (n = 202) treated at our institution from 2015 to 2020 and found five patients diagnosed during pregnancy. In this report, we discu...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2024-10-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1766129 |
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| author | Sukrita Bhattacharjee Shouriyo Ghosh Siddhartha Sankar Ray Sambit Samanta Nilanjan Sinha Sandeep Saha Maitreyee Bhattacharyya |
| author_facet | Sukrita Bhattacharjee Shouriyo Ghosh Siddhartha Sankar Ray Sambit Samanta Nilanjan Sinha Sandeep Saha Maitreyee Bhattacharyya |
| author_sort | Sukrita Bhattacharjee |
| collection | DOAJ |
| description | Acute lymphoblastic leukemia (ALL) diagnosed during pregnancy is rare and causes ethical and therapeutic challenges. We performed a retrospective search of ALL patients (n = 202) treated at our institution from 2015 to 2020 and found five patients diagnosed during pregnancy. In this report, we discuss the individual patients in detail and the challenges faced during their treatment. The use of established lymphoblastic leukemia treatment protocols and the modifications made therein to prevent untoward chemotherapy-related toxicities to the fetus are discussed in this study. We report the second use of rasburicase during pregnancy in literature with favorable maternal and fetal outcomes. We also present an extensive literature review of 41 cases of ALL in pregnancy previously reported. It is important to note that there is a dearth of guidelines for the treatment of these complex situations, and although certain general principles can be established, an individualized approach is needed in most cases of leukemia diagnosed during pregnancy. |
| format | Article |
| id | doaj-art-398036957e254669b2e11ff46ddf0ff1 |
| institution | OA Journals |
| issn | 0971-5851 0975-2129 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-398036957e254669b2e11ff46ddf0ff12025-08-20T02:32:41ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58510975-21292024-10-01450544345010.1055/s-0043-1766129Pregnancy and Acute Lymphoblastic Leukemia: A Case Series and Review of LiteratureSukrita Bhattacharjee0https://orcid.org/0000-0001-8461-6950Shouriyo Ghosh1https://orcid.org/0000-0003-2804-7815Siddhartha Sankar Ray2Sambit Samanta3Nilanjan Sinha4Sandeep Saha5Maitreyee Bhattacharyya6https://orcid.org/0000-0002-6984-168XInstitute of Haematology and Transfusion Medicine, Medical College Kolkata, West Bengal, IndiaL/BMT Program, Vancouver General Hospital, Vancouver, CanadaInstitute of Haematology and Transfusion Medicine, Medical College Kolkata, West Bengal, IndiaInstitute of Haematology and Transfusion Medicine, Medical College Kolkata, West Bengal, IndiaInstitute of Haematology and Transfusion Medicine, Medical College Kolkata, West Bengal, IndiaDepartment of Clinical Haematology, NRS Medical College, Kolkata, West Bengal, IndiaInstitute of Haematology and Transfusion Medicine, Medical College Kolkata, West Bengal, IndiaAcute lymphoblastic leukemia (ALL) diagnosed during pregnancy is rare and causes ethical and therapeutic challenges. We performed a retrospective search of ALL patients (n = 202) treated at our institution from 2015 to 2020 and found five patients diagnosed during pregnancy. In this report, we discuss the individual patients in detail and the challenges faced during their treatment. The use of established lymphoblastic leukemia treatment protocols and the modifications made therein to prevent untoward chemotherapy-related toxicities to the fetus are discussed in this study. We report the second use of rasburicase during pregnancy in literature with favorable maternal and fetal outcomes. We also present an extensive literature review of 41 cases of ALL in pregnancy previously reported. It is important to note that there is a dearth of guidelines for the treatment of these complex situations, and although certain general principles can be established, an individualized approach is needed in most cases of leukemia diagnosed during pregnancy.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1766129acute leukemiaethical considerationspregnancymaternal well-beingfetal outcomechemotherapy |
| spellingShingle | Sukrita Bhattacharjee Shouriyo Ghosh Siddhartha Sankar Ray Sambit Samanta Nilanjan Sinha Sandeep Saha Maitreyee Bhattacharyya Pregnancy and Acute Lymphoblastic Leukemia: A Case Series and Review of Literature Indian Journal of Medical and Paediatric Oncology acute leukemia ethical considerations pregnancy maternal well-being fetal outcome chemotherapy |
| title | Pregnancy and Acute Lymphoblastic Leukemia: A Case Series and Review of Literature |
| title_full | Pregnancy and Acute Lymphoblastic Leukemia: A Case Series and Review of Literature |
| title_fullStr | Pregnancy and Acute Lymphoblastic Leukemia: A Case Series and Review of Literature |
| title_full_unstemmed | Pregnancy and Acute Lymphoblastic Leukemia: A Case Series and Review of Literature |
| title_short | Pregnancy and Acute Lymphoblastic Leukemia: A Case Series and Review of Literature |
| title_sort | pregnancy and acute lymphoblastic leukemia a case series and review of literature |
| topic | acute leukemia ethical considerations pregnancy maternal well-being fetal outcome chemotherapy |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1766129 |
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