Nebulized Pentamidine-Induced Acute Renal Allograft Dysfunction
Acute kidney injury (AKI) is a recognised complication of intravenous pentamidine therapy. A direct nephrotoxic effect leading to acute tubular necrosis has been postulated. We report a case of severe renal allograft dysfunction due to nebulised pentamidine. The patient presented with repeated episo...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2013/907593 |
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| author | Siddhesh Prabhavalkar Agnes Masengu Declan O'Rourke Joanne Shields Aisling Courtney |
| author_facet | Siddhesh Prabhavalkar Agnes Masengu Declan O'Rourke Joanne Shields Aisling Courtney |
| author_sort | Siddhesh Prabhavalkar |
| collection | DOAJ |
| description | Acute kidney injury (AKI) is a recognised complication of intravenous pentamidine therapy. A direct nephrotoxic effect leading to acute tubular necrosis has been postulated. We report a case of severe renal allograft dysfunction due to nebulised pentamidine. The patient presented with repeated episodes of AKI without obvious cause and acute tubular necrosis only on renal histology. Nebulised pentamidine was used monthly as prophylaxis for Pneumocystis jirovecii pneumonia, and administration preceded the creatinine rise on each occasion. Graft function stabilised following discontinuation of the drug. This is the first report of nebulized pentamidine-induced reversible nephrotoxicity in a kidney allograft. This diagnosis should be considered in a case of unexplained acute renal allograft dysfunction. |
| format | Article |
| id | doaj-art-397f84e3d4b0464f988ba5909c7255f7 |
| institution | Kabale University |
| issn | 2090-6943 2090-6951 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Transplantation |
| spelling | doaj-art-397f84e3d4b0464f988ba5909c7255f72025-02-03T01:33:25ZengWileyCase Reports in Transplantation2090-69432090-69512013-01-01201310.1155/2013/907593907593Nebulized Pentamidine-Induced Acute Renal Allograft DysfunctionSiddhesh Prabhavalkar0Agnes Masengu1Declan O'Rourke2Joanne Shields3Aisling Courtney4Regional Nephrology Unit, Belfast City Hospital, Belfast BT9 7AB, UKRegional Nephrology Unit, Belfast City Hospital, Belfast BT9 7AB, UKDepartment of Histopathology, Belfast City Hospital, Belfast BT9 7AB, UKRegional Nephrology Unit, Belfast City Hospital, Belfast BT9 7AB, UKRegional Nephrology Unit, Belfast City Hospital, Belfast BT9 7AB, UKAcute kidney injury (AKI) is a recognised complication of intravenous pentamidine therapy. A direct nephrotoxic effect leading to acute tubular necrosis has been postulated. We report a case of severe renal allograft dysfunction due to nebulised pentamidine. The patient presented with repeated episodes of AKI without obvious cause and acute tubular necrosis only on renal histology. Nebulised pentamidine was used monthly as prophylaxis for Pneumocystis jirovecii pneumonia, and administration preceded the creatinine rise on each occasion. Graft function stabilised following discontinuation of the drug. This is the first report of nebulized pentamidine-induced reversible nephrotoxicity in a kidney allograft. This diagnosis should be considered in a case of unexplained acute renal allograft dysfunction.http://dx.doi.org/10.1155/2013/907593 |
| spellingShingle | Siddhesh Prabhavalkar Agnes Masengu Declan O'Rourke Joanne Shields Aisling Courtney Nebulized Pentamidine-Induced Acute Renal Allograft Dysfunction Case Reports in Transplantation |
| title | Nebulized Pentamidine-Induced Acute Renal Allograft Dysfunction |
| title_full | Nebulized Pentamidine-Induced Acute Renal Allograft Dysfunction |
| title_fullStr | Nebulized Pentamidine-Induced Acute Renal Allograft Dysfunction |
| title_full_unstemmed | Nebulized Pentamidine-Induced Acute Renal Allograft Dysfunction |
| title_short | Nebulized Pentamidine-Induced Acute Renal Allograft Dysfunction |
| title_sort | nebulized pentamidine induced acute renal allograft dysfunction |
| url | http://dx.doi.org/10.1155/2013/907593 |
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