Quantitative ultrasound rating of liver fibrosis in children with cystic fibrosis
Aim of investigation. To determine potential of non-invasive ultrasound techniques of fibroelastometry (FEM) and Acoustic Structure Quantification (ASQ) at liver parenchyma assessment and fibrosis stage grading in children with cystic fibrosis (CF).Material and methods. Overall 89 children in the ag...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2014-08-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1101 |
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| _version_ | 1823860185931710464 |
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| author | G. M. Dvoryakovskaya O. I. Simonova S. A. Ivleva I. V. Dvoryakovsky A. N. Surkov M. O. Gorbunova I. E. Smirnov |
| author_facet | G. M. Dvoryakovskaya O. I. Simonova S. A. Ivleva I. V. Dvoryakovsky A. N. Surkov M. O. Gorbunova I. E. Smirnov |
| author_sort | G. M. Dvoryakovskaya |
| collection | DOAJ |
| description | Aim of investigation. To determine potential of non-invasive ultrasound techniques of fibroelastometry (FEM) and Acoustic Structure Quantification (ASQ) at liver parenchyma assessment and fibrosis stage grading in children with cystic fibrosis (CF).Material and methods. Overall 89 children in the age of 2 months to 18 years with pulmonary and intestinal form of cystic fibrosis were investigated. The course of CF in 64 patients was considered as moderate, in 25 — as severe. The diagnosis was established according to clinical and laboratoric investigation with analysis of past history data, DNA-diagnostics with assessment of genotype and positive sweat test.Results. Evaluation of liver parenchyma with the help of traditional ultrasound investigation with assessment of blood flow in portal vessels and celiac trunk allows to determine degree of hepatic fibrosis severity and to reveal initial signs of portal hypertension. Application of ultrasound techniques of ASQ and FEM objectifies study results as alongside with the qualitative analysis of ultrasound echograms quantitative grading of liver parenchyma and fibrosis stage became possible.Conclusions. ASQ in CF patients can be applied for early detection of fibrosis, follow-up of process development and rating of hepatoprotective treatment efficacy. |
| format | Article |
| id | doaj-art-397e030510754b00b6ec03d9ade2d854 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2014-08-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-397e030510754b00b6ec03d9ade2d8542025-02-10T16:14:33ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732014-08-012423642702Quantitative ultrasound rating of liver fibrosis in children with cystic fibrosisG. M. Dvoryakovskaya0O. I. Simonova1S. A. Ivleva2I. V. Dvoryakovsky3A. N. Surkov4M. O. Gorbunova5I. E. Smirnov6Federal state-funded institution «Children health sciences centre», Russian academy of medical scienceFederal state-funded institution «Children health sciences centre», Russian academy of medical scienceFederal state-funded institution «Children health sciences centre», Russian academy of medical scienceFederal state-funded institution «Children health sciences centre», Russian academy of medical scienceFederal state-funded institution «Children health sciences centre», Russian academy of medical scienceFederal state-funded institution «Children health sciences centre», Russian academy of medical scienceFederal state-funded institution «Children health sciences centre», Russian academy of medical scienceAim of investigation. To determine potential of non-invasive ultrasound techniques of fibroelastometry (FEM) and Acoustic Structure Quantification (ASQ) at liver parenchyma assessment and fibrosis stage grading in children with cystic fibrosis (CF).Material and methods. Overall 89 children in the age of 2 months to 18 years with pulmonary and intestinal form of cystic fibrosis were investigated. The course of CF in 64 patients was considered as moderate, in 25 — as severe. The diagnosis was established according to clinical and laboratoric investigation with analysis of past history data, DNA-diagnostics with assessment of genotype and positive sweat test.Results. Evaluation of liver parenchyma with the help of traditional ultrasound investigation with assessment of blood flow in portal vessels and celiac trunk allows to determine degree of hepatic fibrosis severity and to reveal initial signs of portal hypertension. Application of ultrasound techniques of ASQ and FEM objectifies study results as alongside with the qualitative analysis of ultrasound echograms quantitative grading of liver parenchyma and fibrosis stage became possible.Conclusions. ASQ in CF patients can be applied for early detection of fibrosis, follow-up of process development and rating of hepatoprotective treatment efficacy.https://www.gastro-j.ru/jour/article/view/1101cystic fibrosis in childrenfibrosisultrasound investigation of the liverdiagnostic significance |
| spellingShingle | G. M. Dvoryakovskaya O. I. Simonova S. A. Ivleva I. V. Dvoryakovsky A. N. Surkov M. O. Gorbunova I. E. Smirnov Quantitative ultrasound rating of liver fibrosis in children with cystic fibrosis Российский журнал гастроэнтерологии, гепатологии, колопроктологии cystic fibrosis in children fibrosis ultrasound investigation of the liver diagnostic significance |
| title | Quantitative ultrasound rating of liver fibrosis in children with cystic fibrosis |
| title_full | Quantitative ultrasound rating of liver fibrosis in children with cystic fibrosis |
| title_fullStr | Quantitative ultrasound rating of liver fibrosis in children with cystic fibrosis |
| title_full_unstemmed | Quantitative ultrasound rating of liver fibrosis in children with cystic fibrosis |
| title_short | Quantitative ultrasound rating of liver fibrosis in children with cystic fibrosis |
| title_sort | quantitative ultrasound rating of liver fibrosis in children with cystic fibrosis |
| topic | cystic fibrosis in children fibrosis ultrasound investigation of the liver diagnostic significance |
| url | https://www.gastro-j.ru/jour/article/view/1101 |
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