Evaluation of Clinical and Ultrasonographic Parameters in Psoriatic Arthritis Patients Treated with Adalimumab: A Retrospective Study
Objectives. The aim of this study was to evaluate clinical and US-PD parameters in PsA during adalimumab treatment. Methods. A retrospective study has been conducted in forty patients affected by moderate-to-severe peripheral PsA. Clinical, laboratory, and US-PD evaluations were performed at baselin...
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| Format: | Article |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/823854 |
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| author | M. Teoli A. Zangrilli M. S. Chimenti M. Talamonti M. Bavetta D. Graceffa R. Perricone S. Chimenti |
| author_facet | M. Teoli A. Zangrilli M. S. Chimenti M. Talamonti M. Bavetta D. Graceffa R. Perricone S. Chimenti |
| author_sort | M. Teoli |
| collection | DOAJ |
| description | Objectives. The aim of this study was to evaluate clinical and US-PD parameters in PsA during adalimumab treatment. Methods. A retrospective study has been conducted in forty patients affected by moderate-to-severe peripheral PsA. Clinical, laboratory, and US-PD evaluations were performed at baseline, after 4, 12, and 24 weeks of treatment. They included erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), visual analogue scale (VAS), Health Assessment Questionnaire (HAQ) modified for Spondyloarthritis, Psoriasis Area Severity Index (PASI) score, the 28-joint Disease Activity Score (DAS 28), and US-PD assessment. US-PD findings were scored according to a semiquantitative scale (ranging 0–3) for synovial proliferation (SP), joint effusion (SE), bone erosions (BE), and PD. Results. Data obtained for clinical, laboratory findings and US-PD evaluation showed statistical significant improvement in all the measures performed except for BE. A significant parallel decrease in SE, SP, and PD values were demonstrated. Conclusion. This study demonstrated that US-PD is a valid technique in monitoring the response to adalimumab in moderate-to-severe PsA. |
| format | Article |
| id | doaj-art-397c262bcc5f4f8ebd86c1748bff1d68 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-397c262bcc5f4f8ebd86c1748bff1d682025-08-20T03:55:11ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/823854823854Evaluation of Clinical and Ultrasonographic Parameters in Psoriatic Arthritis Patients Treated with Adalimumab: A Retrospective StudyM. Teoli0A. Zangrilli1M. S. Chimenti2M. Talamonti3M. Bavetta4D. Graceffa5R. Perricone6S. Chimenti7Department of Dermatology, University of Rome “Tor Vergata”, Viale Oxford 81, 00133 Rome, ItalyDepartment of Dermatology, University of Rome “Tor Vergata”, Viale Oxford 81, 00133 Rome, ItalyDepartment of Rheumatology, University of Rome “Tor Vergata”, Viale Oxford 81, 00133 Rome, ItalyDepartment of Dermatology, University of Rome “Tor Vergata”, Viale Oxford 81, 00133 Rome, ItalyDepartment of Dermatology, University of Rome “Tor Vergata”, Viale Oxford 81, 00133 Rome, ItalyDepartment of Rheumatology, University of Rome “Tor Vergata”, Viale Oxford 81, 00133 Rome, ItalyDepartment of Rheumatology, University of Rome “Tor Vergata”, Viale Oxford 81, 00133 Rome, ItalyDepartment of Dermatology, University of Rome “Tor Vergata”, Viale Oxford 81, 00133 Rome, ItalyObjectives. The aim of this study was to evaluate clinical and US-PD parameters in PsA during adalimumab treatment. Methods. A retrospective study has been conducted in forty patients affected by moderate-to-severe peripheral PsA. Clinical, laboratory, and US-PD evaluations were performed at baseline, after 4, 12, and 24 weeks of treatment. They included erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), visual analogue scale (VAS), Health Assessment Questionnaire (HAQ) modified for Spondyloarthritis, Psoriasis Area Severity Index (PASI) score, the 28-joint Disease Activity Score (DAS 28), and US-PD assessment. US-PD findings were scored according to a semiquantitative scale (ranging 0–3) for synovial proliferation (SP), joint effusion (SE), bone erosions (BE), and PD. Results. Data obtained for clinical, laboratory findings and US-PD evaluation showed statistical significant improvement in all the measures performed except for BE. A significant parallel decrease in SE, SP, and PD values were demonstrated. Conclusion. This study demonstrated that US-PD is a valid technique in monitoring the response to adalimumab in moderate-to-severe PsA.http://dx.doi.org/10.1155/2012/823854 |
| spellingShingle | M. Teoli A. Zangrilli M. S. Chimenti M. Talamonti M. Bavetta D. Graceffa R. Perricone S. Chimenti Evaluation of Clinical and Ultrasonographic Parameters in Psoriatic Arthritis Patients Treated with Adalimumab: A Retrospective Study Clinical and Developmental Immunology |
| title | Evaluation of Clinical and Ultrasonographic Parameters in Psoriatic Arthritis Patients Treated with Adalimumab: A Retrospective Study |
| title_full | Evaluation of Clinical and Ultrasonographic Parameters in Psoriatic Arthritis Patients Treated with Adalimumab: A Retrospective Study |
| title_fullStr | Evaluation of Clinical and Ultrasonographic Parameters in Psoriatic Arthritis Patients Treated with Adalimumab: A Retrospective Study |
| title_full_unstemmed | Evaluation of Clinical and Ultrasonographic Parameters in Psoriatic Arthritis Patients Treated with Adalimumab: A Retrospective Study |
| title_short | Evaluation of Clinical and Ultrasonographic Parameters in Psoriatic Arthritis Patients Treated with Adalimumab: A Retrospective Study |
| title_sort | evaluation of clinical and ultrasonographic parameters in psoriatic arthritis patients treated with adalimumab a retrospective study |
| url | http://dx.doi.org/10.1155/2012/823854 |
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