Liposomal and Lipid-Based Drug Delivery Systems: Bridging Gut Microbiota and Pediatric Disorder Treatments
The intestine is an important segment of the gastrointestinal tract, which is involved in complex processes that maintain the body’s normal homeostasis. It hosts a vast, diverse, and dynamic microbial community called the gut microbiota, which develops from birth. It has been observed that the gut m...
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2025-05-01
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| Online Access: | https://www.mdpi.com/1999-4923/17/6/707 |
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| author | Raluca Ioana Teleanu Elena-Theodora Moldoveanu Adelina-Gabriela Niculescu Elena Predescu Eugenia Roza Iulia Florentina Tincu Alexandru Mihai Grumezescu Daniel Mihai Teleanu |
| author_facet | Raluca Ioana Teleanu Elena-Theodora Moldoveanu Adelina-Gabriela Niculescu Elena Predescu Eugenia Roza Iulia Florentina Tincu Alexandru Mihai Grumezescu Daniel Mihai Teleanu |
| author_sort | Raluca Ioana Teleanu |
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| description | The intestine is an important segment of the gastrointestinal tract, which is involved in complex processes that maintain the body’s normal homeostasis. It hosts a vast, diverse, and dynamic microbial community called the gut microbiota, which develops from birth. It has been observed that the gut microbiota is involved in essential physiological processes, including the development of the central nervous system via the gut microbiota–brain axis. An alteration of the gut microbiota can lead to serious health problems, including defective neurodevelopment. Thus, this paper aims to highlight the most recent advances in studies that focus on the link between the gut microbiota and the evolution of neurodevelopmental diseases in children. Currently, studies show that the use of drugs that stimulate and restore the gut microbiota (e.g., probiotics and prebiotics) have the potential to alleviate some of the symptoms associated with conditions such as Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder, Tic Disorder, Tourette Syndrome, epilepsy, and Down Syndrome. In addition, due to the challenges associated with drug administration in children, as well as the widespread shortage of medications intended for pediatric use, researchers are working on the development of new delivery systems. Liposome-based systems or solid lipid nanoparticles have been safely used for drug delivery in various pediatric conditions, which may also indicate their potential for use in the administration of microbiota-modulating therapies. |
| format | Article |
| id | doaj-art-3975b1381fbd4c58b40b5c5ab7e033fa |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-3975b1381fbd4c58b40b5c5ab7e033fa2025-08-20T03:27:41ZengMDPI AGPharmaceutics1999-49232025-05-0117670710.3390/pharmaceutics17060707Liposomal and Lipid-Based Drug Delivery Systems: Bridging Gut Microbiota and Pediatric Disorder TreatmentsRaluca Ioana Teleanu0Elena-Theodora Moldoveanu1Adelina-Gabriela Niculescu2Elena Predescu3Eugenia Roza4Iulia Florentina Tincu5Alexandru Mihai Grumezescu6Daniel Mihai Teleanu7Department of Neuroscience, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, 011061 Bucharest, RomaniaDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, 011061 Bucharest, RomaniaDepartment of Neuroscience, Psychiatry and Pediatric Psychiatry, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400658 Cluj-Napoca, RomaniaDepartment of Neuroscience, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Paediatrics, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, 011061 Bucharest, RomaniaDepartment of Neuroscience, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaThe intestine is an important segment of the gastrointestinal tract, which is involved in complex processes that maintain the body’s normal homeostasis. It hosts a vast, diverse, and dynamic microbial community called the gut microbiota, which develops from birth. It has been observed that the gut microbiota is involved in essential physiological processes, including the development of the central nervous system via the gut microbiota–brain axis. An alteration of the gut microbiota can lead to serious health problems, including defective neurodevelopment. Thus, this paper aims to highlight the most recent advances in studies that focus on the link between the gut microbiota and the evolution of neurodevelopmental diseases in children. Currently, studies show that the use of drugs that stimulate and restore the gut microbiota (e.g., probiotics and prebiotics) have the potential to alleviate some of the symptoms associated with conditions such as Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder, Tic Disorder, Tourette Syndrome, epilepsy, and Down Syndrome. In addition, due to the challenges associated with drug administration in children, as well as the widespread shortage of medications intended for pediatric use, researchers are working on the development of new delivery systems. Liposome-based systems or solid lipid nanoparticles have been safely used for drug delivery in various pediatric conditions, which may also indicate their potential for use in the administration of microbiota-modulating therapies.https://www.mdpi.com/1999-4923/17/6/707gut microbiotachildren neurodevelopmental disordersliposomal drug delivery systemssolid lipid nanoparticlesprobioticsprebiotics |
| spellingShingle | Raluca Ioana Teleanu Elena-Theodora Moldoveanu Adelina-Gabriela Niculescu Elena Predescu Eugenia Roza Iulia Florentina Tincu Alexandru Mihai Grumezescu Daniel Mihai Teleanu Liposomal and Lipid-Based Drug Delivery Systems: Bridging Gut Microbiota and Pediatric Disorder Treatments Pharmaceutics gut microbiota children neurodevelopmental disorders liposomal drug delivery systems solid lipid nanoparticles probiotics prebiotics |
| title | Liposomal and Lipid-Based Drug Delivery Systems: Bridging Gut Microbiota and Pediatric Disorder Treatments |
| title_full | Liposomal and Lipid-Based Drug Delivery Systems: Bridging Gut Microbiota and Pediatric Disorder Treatments |
| title_fullStr | Liposomal and Lipid-Based Drug Delivery Systems: Bridging Gut Microbiota and Pediatric Disorder Treatments |
| title_full_unstemmed | Liposomal and Lipid-Based Drug Delivery Systems: Bridging Gut Microbiota and Pediatric Disorder Treatments |
| title_short | Liposomal and Lipid-Based Drug Delivery Systems: Bridging Gut Microbiota and Pediatric Disorder Treatments |
| title_sort | liposomal and lipid based drug delivery systems bridging gut microbiota and pediatric disorder treatments |
| topic | gut microbiota children neurodevelopmental disorders liposomal drug delivery systems solid lipid nanoparticles probiotics prebiotics |
| url | https://www.mdpi.com/1999-4923/17/6/707 |
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