Correlations between ghrelin gene polymorphisms, cognitive function, and activities of daily living among elderly patients with Alzheimer’s disease
Background Single nucleotide polymorphisms (SNPs) of ghrelin gene are associated with cognitive function while ghrelin is associated with Alzheimer’s disease (AD).Aim To determine the relationship between ghrelin SNPs, cognitive function, and activities of daily living (ADLs) in elderly AD patients....
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| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Annals of Human Biology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/03014460.2025.2507048 |
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| author | Wenguang Liu Liyuan Wu Jiaying Hu Zhiyong Gao |
| author_facet | Wenguang Liu Liyuan Wu Jiaying Hu Zhiyong Gao |
| author_sort | Wenguang Liu |
| collection | DOAJ |
| description | Background Single nucleotide polymorphisms (SNPs) of ghrelin gene are associated with cognitive function while ghrelin is associated with Alzheimer’s disease (AD).Aim To determine the relationship between ghrelin SNPs, cognitive function, and activities of daily living (ADLs) in elderly AD patients.Subjects and methods This study included 100 elderly AD patients as the AD group, and 72 elderly healthy patients as the control group. Pearson’s correlation analysis was performed.Results The frequency of the A allele at rs55821288 was significantly higher in the AD group than the control group (p < 0.05). Similarly, the frequency of the AA genotype at rs55821288 was higher in the AD group than the control group (p < 0.05). The MMSE, QOL-AD, and ADLs scores were lower in the AD group than the control group (p < 0.05). Pearson’s correlation analysis revealed that the A allele at rs55821288 was inversely correlated with the MMSE, QOL-AD, and ADLs scores (p < 0.05). The distribution of the AA genotype at the rs55821288 locus had a negative linear correlation with the MMSE, QOL-AD, and ADLs scores (p < 0.05).Conclusions Ghrelin allele A and genotype AA are closely associated with cognitive function and ADLs among elderly AD patients. |
| format | Article |
| id | doaj-art-396e59d3758945e8904e3ab4d5eb0d27 |
| institution | OA Journals |
| issn | 0301-4460 1464-5033 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Human Biology |
| spelling | doaj-art-396e59d3758945e8904e3ab4d5eb0d272025-08-20T02:02:54ZengTaylor & Francis GroupAnnals of Human Biology0301-44601464-50332025-12-0152110.1080/03014460.2025.2507048Correlations between ghrelin gene polymorphisms, cognitive function, and activities of daily living among elderly patients with Alzheimer’s diseaseWenguang Liu0Liyuan Wu1Jiaying Hu2Zhiyong Gao3Zhejiang Provincial Clinical Research Center for Mental Health Psychiatry, The Affiliated Kangning Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, ChinaZhejiang Provincial Clinical Research Center for Mental Health Psychiatry, The Affiliated Kangning Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, ChinaZhejiang Provincial Clinical Research Center for Mental Health Psychiatry, The Affiliated Kangning Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, ChinaZhejiang Provincial Clinical Research Center for Mental Health Psychiatry, The Affiliated Kangning Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, ChinaBackground Single nucleotide polymorphisms (SNPs) of ghrelin gene are associated with cognitive function while ghrelin is associated with Alzheimer’s disease (AD).Aim To determine the relationship between ghrelin SNPs, cognitive function, and activities of daily living (ADLs) in elderly AD patients.Subjects and methods This study included 100 elderly AD patients as the AD group, and 72 elderly healthy patients as the control group. Pearson’s correlation analysis was performed.Results The frequency of the A allele at rs55821288 was significantly higher in the AD group than the control group (p < 0.05). Similarly, the frequency of the AA genotype at rs55821288 was higher in the AD group than the control group (p < 0.05). The MMSE, QOL-AD, and ADLs scores were lower in the AD group than the control group (p < 0.05). Pearson’s correlation analysis revealed that the A allele at rs55821288 was inversely correlated with the MMSE, QOL-AD, and ADLs scores (p < 0.05). The distribution of the AA genotype at the rs55821288 locus had a negative linear correlation with the MMSE, QOL-AD, and ADLs scores (p < 0.05).Conclusions Ghrelin allele A and genotype AA are closely associated with cognitive function and ADLs among elderly AD patients.https://www.tandfonline.com/doi/10.1080/03014460.2025.2507048Ghrelin genesingle nucleotide polymorphism (SNP)activities of daily living (ADLs)cognitive functioncorrelation analysis |
| spellingShingle | Wenguang Liu Liyuan Wu Jiaying Hu Zhiyong Gao Correlations between ghrelin gene polymorphisms, cognitive function, and activities of daily living among elderly patients with Alzheimer’s disease Annals of Human Biology Ghrelin gene single nucleotide polymorphism (SNP) activities of daily living (ADLs) cognitive function correlation analysis |
| title | Correlations between ghrelin gene polymorphisms, cognitive function, and activities of daily living among elderly patients with Alzheimer’s disease |
| title_full | Correlations between ghrelin gene polymorphisms, cognitive function, and activities of daily living among elderly patients with Alzheimer’s disease |
| title_fullStr | Correlations between ghrelin gene polymorphisms, cognitive function, and activities of daily living among elderly patients with Alzheimer’s disease |
| title_full_unstemmed | Correlations between ghrelin gene polymorphisms, cognitive function, and activities of daily living among elderly patients with Alzheimer’s disease |
| title_short | Correlations between ghrelin gene polymorphisms, cognitive function, and activities of daily living among elderly patients with Alzheimer’s disease |
| title_sort | correlations between ghrelin gene polymorphisms cognitive function and activities of daily living among elderly patients with alzheimer s disease |
| topic | Ghrelin gene single nucleotide polymorphism (SNP) activities of daily living (ADLs) cognitive function correlation analysis |
| url | https://www.tandfonline.com/doi/10.1080/03014460.2025.2507048 |
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