Heme-induced lung injury in human precision cut lung slices: a new model for acute lung injury

Heme-induced lung injury in human precision cut lung slices: a new model for acute lung injury

Abstract Background Acute respiratory distress syndrome (ARDS) causes high mortality and has no specific pharmacological treatment. Scarcity of drugs against ARDS is in part due to the lack of models for ARDS. As raised serum heme levels are associated with higher mortality in patients with ARDS, we...

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Main Authors: Namrata Kewalramani, Carlos Machahua, Thomas Michael Marti, Cas Zandbergen, Savvina Chortarea, Jessica Beretta-Piccoli, Christophe von Garnier, Patrick Dorn, Kleanthis Fytianos, Manuela Funke-Chambour
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Respiratory Research
Subjects:
Acute respiratory distress syndrome
Precision cut lung slices
Heme
Transcriptomics
Proteomics
Inflammation
Online Access:https://doi.org/10.1186/s12931-025-03191-z
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