Acquired von Willebrand Syndrome in IgM Monoclonal Gammopathy as the Presentation of Lymphoplasmacytic Lymphoma
Acquired von Willebrand syndrome (AVWS) is an increasingly recognized entity with numerous potential underlying etiologies. Most commonly implicated are lymphoproliferative, myeloproliferative, cardiovascular, and autoimmune disorders. Unlike inherited von Willebrand disease (vWD), AVWS tends to pre...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2017/9862620 |
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| _version_ | 1832567362595848192 |
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| author | Zachary Wolfe Bradley Lash |
| author_facet | Zachary Wolfe Bradley Lash |
| author_sort | Zachary Wolfe |
| collection | DOAJ |
| description | Acquired von Willebrand syndrome (AVWS) is an increasingly recognized entity with numerous potential underlying etiologies. Most commonly implicated are lymphoproliferative, myeloproliferative, cardiovascular, and autoimmune disorders. Unlike inherited von Willebrand disease (vWD), AVWS tends to present at an older age and without a family history of vWD. Treatment is directed at the underlying etiology if one is uncovered, as well as treatment and prevention of bleeding. Here, we present a rare case of AVWS secondary to Waldenström macroglobulinemia which went unrecognized for several years but resolved promptly with treatment. The potential mechanisms of AVWS secondary to monoclonal gammopathies are discussed as well as strategies to treat and prevent bleeding in these patients. |
| format | Article |
| id | doaj-art-3966cedb009b4bfeb5ad0270c3fd0776 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-3966cedb009b4bfeb5ad0270c3fd07762025-02-03T01:01:37ZengWileyCase Reports in Hematology2090-65602090-65792017-01-01201710.1155/2017/98626209862620Acquired von Willebrand Syndrome in IgM Monoclonal Gammopathy as the Presentation of Lymphoplasmacytic LymphomaZachary Wolfe0Bradley Lash1Department of Internal Medicine, Guthrie Clinic/Robert Packer Hospital, Sayre, PA, USADepartment of Hematology and Oncology, Guthrie Clinic/Robert Packer Hospital, Sayre, PA, USAAcquired von Willebrand syndrome (AVWS) is an increasingly recognized entity with numerous potential underlying etiologies. Most commonly implicated are lymphoproliferative, myeloproliferative, cardiovascular, and autoimmune disorders. Unlike inherited von Willebrand disease (vWD), AVWS tends to present at an older age and without a family history of vWD. Treatment is directed at the underlying etiology if one is uncovered, as well as treatment and prevention of bleeding. Here, we present a rare case of AVWS secondary to Waldenström macroglobulinemia which went unrecognized for several years but resolved promptly with treatment. The potential mechanisms of AVWS secondary to monoclonal gammopathies are discussed as well as strategies to treat and prevent bleeding in these patients.http://dx.doi.org/10.1155/2017/9862620 |
| spellingShingle | Zachary Wolfe Bradley Lash Acquired von Willebrand Syndrome in IgM Monoclonal Gammopathy as the Presentation of Lymphoplasmacytic Lymphoma Case Reports in Hematology |
| title | Acquired von Willebrand Syndrome in IgM Monoclonal Gammopathy as the Presentation of Lymphoplasmacytic Lymphoma |
| title_full | Acquired von Willebrand Syndrome in IgM Monoclonal Gammopathy as the Presentation of Lymphoplasmacytic Lymphoma |
| title_fullStr | Acquired von Willebrand Syndrome in IgM Monoclonal Gammopathy as the Presentation of Lymphoplasmacytic Lymphoma |
| title_full_unstemmed | Acquired von Willebrand Syndrome in IgM Monoclonal Gammopathy as the Presentation of Lymphoplasmacytic Lymphoma |
| title_short | Acquired von Willebrand Syndrome in IgM Monoclonal Gammopathy as the Presentation of Lymphoplasmacytic Lymphoma |
| title_sort | acquired von willebrand syndrome in igm monoclonal gammopathy as the presentation of lymphoplasmacytic lymphoma |
| url | http://dx.doi.org/10.1155/2017/9862620 |
| work_keys_str_mv | AT zacharywolfe acquiredvonwillebrandsyndromeinigmmonoclonalgammopathyasthepresentationoflymphoplasmacyticlymphoma AT bradleylash acquiredvonwillebrandsyndromeinigmmonoclonalgammopathyasthepresentationoflymphoplasmacyticlymphoma |