Cannabis Use in Pregnancy and Downstream effects on maternal and infant health (CUPiD): a protocol for a birth cohort pilot study
Introduction Cannabis use in pregnancy and post partum is increasing. Accessibility to cannabis has expanded due to the legalisation of cannabis in Canada. Therefore, there is a critical need to monitor the impact of cannabis on pregnancy outcomes and infant neurodevelopment. This pilot study will a...
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BMJ Publishing Group
2022-12-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/12/e066196.full |
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| author | Mark C Walker Darine El-Chaâr Daniel J Corsi Malia S Q Murphy Ruth Rennicks White Serine Ramlawi Alysha L J Dingwall-Harvey Laura M Gaudet Amy McGee Amanda DeGrace Christina Cantin |
| author_facet | Mark C Walker Darine El-Chaâr Daniel J Corsi Malia S Q Murphy Ruth Rennicks White Serine Ramlawi Alysha L J Dingwall-Harvey Laura M Gaudet Amy McGee Amanda DeGrace Christina Cantin |
| author_sort | Mark C Walker |
| collection | DOAJ |
| description | Introduction Cannabis use in pregnancy and post partum is increasing. Accessibility to cannabis has expanded due to the legalisation of cannabis in Canada. Therefore, there is a critical need to monitor the impact of cannabis on pregnancy outcomes and infant neurodevelopment. This pilot study will assess the feasibility of modern recruitment and data collection strategies adapted to the current cannabis environment and inform the design of a multicentre prospective birth cohort.Methods and analysis We will establish a pregnancy and birth cohort of 50 cannabis users and 50 non-users recruited before delivery. We will follow the participants at regular visits from recruitment to 12 weeks post partum. Participants will provide demographic and socioeconomic data, report their cannabis use patterns, and provide biological samples. Biological samples include maternal and infant urine and blood, breastmilk/chestmilk, cord blood, cord tissue, placenta and meconium. All samples will be processed and stored at −80°C until analysis by immunoassay or liquid chromatography-tandem mass spectrometry to determine the presence of cannabis metabolites. In addition, partners will be invited to provide additional socioeconomic and substance use data.Ethics and dissemination Ethics was obtained from Ottawa Health Science Network Research Ethics Board through Clinical Trials Ontario (3791). Our findings will be published in peer-reviewed journals, presented at scientific conferences and shared broadly with patients, healthcare decision-makers, and project partners online and through social media.Trial registration number NCT05309226.Cite Now |
| format | Article |
| id | doaj-art-39606099792b41e7a69f3e23e8bead27 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-39606099792b41e7a69f3e23e8bead272025-08-20T02:16:05ZengBMJ Publishing GroupBMJ Open2044-60552022-12-01121210.1136/bmjopen-2022-066196Cannabis Use in Pregnancy and Downstream effects on maternal and infant health (CUPiD): a protocol for a birth cohort pilot studyMark C Walker0Darine El-Chaâr1Daniel J Corsi2Malia S Q Murphy3Ruth Rennicks White4Serine Ramlawi5Alysha L J Dingwall-Harvey6Laura M Gaudet7Amy McGee8Amanda DeGrace9Christina Cantin10Children`s Hospital of Eastern Ontario Research Institute, Ottawa, ON, CanadaOttawa Hospital Research Institute, Clinical Epidemiology Program, Ottawa, ON, CanadaSchool of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, CanadaClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, CanadaClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, CanadaClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, CanadaClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, CanadaDepartment of Obstetrics and Gynecology, Queen’s University, Kingston, Ontario, CanadaDivision of Midwifery, Ottawa Hospital, Ottawa, Ontario, CanadaClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, CanadaFaculty of Health Sciences, Queen`s University, Kingston, Ontario, CanadaIntroduction Cannabis use in pregnancy and post partum is increasing. Accessibility to cannabis has expanded due to the legalisation of cannabis in Canada. Therefore, there is a critical need to monitor the impact of cannabis on pregnancy outcomes and infant neurodevelopment. This pilot study will assess the feasibility of modern recruitment and data collection strategies adapted to the current cannabis environment and inform the design of a multicentre prospective birth cohort.Methods and analysis We will establish a pregnancy and birth cohort of 50 cannabis users and 50 non-users recruited before delivery. We will follow the participants at regular visits from recruitment to 12 weeks post partum. Participants will provide demographic and socioeconomic data, report their cannabis use patterns, and provide biological samples. Biological samples include maternal and infant urine and blood, breastmilk/chestmilk, cord blood, cord tissue, placenta and meconium. All samples will be processed and stored at −80°C until analysis by immunoassay or liquid chromatography-tandem mass spectrometry to determine the presence of cannabis metabolites. In addition, partners will be invited to provide additional socioeconomic and substance use data.Ethics and dissemination Ethics was obtained from Ottawa Health Science Network Research Ethics Board through Clinical Trials Ontario (3791). Our findings will be published in peer-reviewed journals, presented at scientific conferences and shared broadly with patients, healthcare decision-makers, and project partners online and through social media.Trial registration number NCT05309226.Cite Nowhttps://bmjopen.bmj.com/content/12/12/e066196.full |
| spellingShingle | Mark C Walker Darine El-Chaâr Daniel J Corsi Malia S Q Murphy Ruth Rennicks White Serine Ramlawi Alysha L J Dingwall-Harvey Laura M Gaudet Amy McGee Amanda DeGrace Christina Cantin Cannabis Use in Pregnancy and Downstream effects on maternal and infant health (CUPiD): a protocol for a birth cohort pilot study BMJ Open |
| title | Cannabis Use in Pregnancy and Downstream effects on maternal and infant health (CUPiD): a protocol for a birth cohort pilot study |
| title_full | Cannabis Use in Pregnancy and Downstream effects on maternal and infant health (CUPiD): a protocol for a birth cohort pilot study |
| title_fullStr | Cannabis Use in Pregnancy and Downstream effects on maternal and infant health (CUPiD): a protocol for a birth cohort pilot study |
| title_full_unstemmed | Cannabis Use in Pregnancy and Downstream effects on maternal and infant health (CUPiD): a protocol for a birth cohort pilot study |
| title_short | Cannabis Use in Pregnancy and Downstream effects on maternal and infant health (CUPiD): a protocol for a birth cohort pilot study |
| title_sort | cannabis use in pregnancy and downstream effects on maternal and infant health cupid a protocol for a birth cohort pilot study |
| url | https://bmjopen.bmj.com/content/12/12/e066196.full |
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