Investigating consequences of non-synonymous Single nucleotide polymorphisms of the Zyxin gene on protein structure and functions in Nigerian indigenous and Nera black chickens Zyxin
Zyxin functions as a regulator of the restructuring of the actin cytoskeleton during the process of repairing tissue damage, cell movement and attachment. It has also been identified as a potential gene involved in chicken coccidiosis. In order to gain a deeper understanding of these phenomena, we...
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Editora da Universidade Estadual de Maringá (Eduem)
2025-03-01
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| Series: | Acta Scientiarum: Animal Sciences |
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| Online Access: | https://periodicos.uem.br/ojs/index.php/ActaSciAnimSci/article/view/71608 |
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| author | Adenaike Adeyemi Sunday Peters Sunday Olusola Fafiolu Adeboye Olusesan Waheed Abdullai Adetunji Abdulrahman Taofeek Aireabakhame Agaviezor Brilliant Ogagaoghene Agbalaya Khadijah Kubura Ikeobi Christian Obiora Ndubuisi |
| author_facet | Adenaike Adeyemi Sunday Peters Sunday Olusola Fafiolu Adeboye Olusesan Waheed Abdullai Adetunji Abdulrahman Taofeek Aireabakhame Agaviezor Brilliant Ogagaoghene Agbalaya Khadijah Kubura Ikeobi Christian Obiora Ndubuisi |
| author_sort | Adenaike Adeyemi Sunday |
| collection | DOAJ |
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Zyxin functions as a regulator of the restructuring of the actin cytoskeleton during the process of repairing tissue damage, cell movement and attachment. It has also been identified as a potential gene involved in chicken coccidiosis. In order to gain a deeper understanding of these phenomena, we employed a collection of computer-based techniques and databases to examine the amino acid sequence, structural dynamics, molecular interactions, and activities of the gene. Our analysis revealed that Zyxin contains two non-synonymous SNPs (A > C at position 22 and G > A at position 137) at exon 1. Also, there existed a non-synonymous SNPs in Exon 3 (A>C and A>T both at position 861) of the gene with Synonymous SNPs observed only in exon 3 (A>G at position 812 and 854, T > C at position 863). The genetic diversity revealed in these chicken populations indicates the presence of genetic variation, with Naked neck chickens showing a considerably higher frequency of particular SNPs. Two non-synonymous single nucleotide polymorphisms (nsSNPs) were forecasted to exert a profound influence on the structure, stability, and activities of Zyxin, thereby heightening the vulnerability to coccidiosis.
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| format | Article |
| id | doaj-art-395d005e822d4cc89ef76b4db4066ec2 |
| institution | DOAJ |
| issn | 1806-2636 1807-8672 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Editora da Universidade Estadual de Maringá (Eduem) |
| record_format | Article |
| series | Acta Scientiarum: Animal Sciences |
| spelling | doaj-art-395d005e822d4cc89ef76b4db4066ec22025-08-20T02:41:58ZengEditora da Universidade Estadual de Maringá (Eduem)Acta Scientiarum: Animal Sciences1806-26361807-86722025-03-0147110.4025/actascianimsci.v47i1.71608Investigating consequences of non-synonymous Single nucleotide polymorphisms of the Zyxin gene on protein structure and functions in Nigerian indigenous and Nera black chickens ZyxinAdenaike Adeyemi Sunday0Peters Sunday Olusola1Fafiolu Adeboye Olusesan2Waheed Abdullai Adetunji3Abdulrahman Taofeek Aireabakhame4Agaviezor Brilliant Ogagaoghene5Agbalaya Khadijah Kubura6Ikeobi Christian Obiora Ndubuisi7Federal University of Agriculture / University of Port HarcourtBerry College, Federal University of AgricultureFederal University of AgricultureFederal University of AgricultureUniversity of Port Harcourt Lagos State University of Science and TechnologyFederal University of Agriculture Zyxin functions as a regulator of the restructuring of the actin cytoskeleton during the process of repairing tissue damage, cell movement and attachment. It has also been identified as a potential gene involved in chicken coccidiosis. In order to gain a deeper understanding of these phenomena, we employed a collection of computer-based techniques and databases to examine the amino acid sequence, structural dynamics, molecular interactions, and activities of the gene. Our analysis revealed that Zyxin contains two non-synonymous SNPs (A > C at position 22 and G > A at position 137) at exon 1. Also, there existed a non-synonymous SNPs in Exon 3 (A>C and A>T both at position 861) of the gene with Synonymous SNPs observed only in exon 3 (A>G at position 812 and 854, T > C at position 863). The genetic diversity revealed in these chicken populations indicates the presence of genetic variation, with Naked neck chickens showing a considerably higher frequency of particular SNPs. Two non-synonymous single nucleotide polymorphisms (nsSNPs) were forecasted to exert a profound influence on the structure, stability, and activities of Zyxin, thereby heightening the vulnerability to coccidiosis. https://periodicos.uem.br/ojs/index.php/ActaSciAnimSci/article/view/71608Zyxin; chicken coccidiosis; amino acid sequence; non-synonymous SNPs; naked neck chickens; single nucleotide polymorphisms (SNPs); nsSNPs. |
| spellingShingle | Adenaike Adeyemi Sunday Peters Sunday Olusola Fafiolu Adeboye Olusesan Waheed Abdullai Adetunji Abdulrahman Taofeek Aireabakhame Agaviezor Brilliant Ogagaoghene Agbalaya Khadijah Kubura Ikeobi Christian Obiora Ndubuisi Investigating consequences of non-synonymous Single nucleotide polymorphisms of the Zyxin gene on protein structure and functions in Nigerian indigenous and Nera black chickens Zyxin Acta Scientiarum: Animal Sciences Zyxin; chicken coccidiosis; amino acid sequence; non-synonymous SNPs; naked neck chickens; single nucleotide polymorphisms (SNPs); nsSNPs. |
| title | Investigating consequences of non-synonymous Single nucleotide polymorphisms of the Zyxin gene on protein structure and functions in Nigerian indigenous and Nera black chickens Zyxin |
| title_full | Investigating consequences of non-synonymous Single nucleotide polymorphisms of the Zyxin gene on protein structure and functions in Nigerian indigenous and Nera black chickens Zyxin |
| title_fullStr | Investigating consequences of non-synonymous Single nucleotide polymorphisms of the Zyxin gene on protein structure and functions in Nigerian indigenous and Nera black chickens Zyxin |
| title_full_unstemmed | Investigating consequences of non-synonymous Single nucleotide polymorphisms of the Zyxin gene on protein structure and functions in Nigerian indigenous and Nera black chickens Zyxin |
| title_short | Investigating consequences of non-synonymous Single nucleotide polymorphisms of the Zyxin gene on protein structure and functions in Nigerian indigenous and Nera black chickens Zyxin |
| title_sort | investigating consequences of non synonymous single nucleotide polymorphisms of the zyxin gene on protein structure and functions in nigerian indigenous and nera black chickens zyxin |
| topic | Zyxin; chicken coccidiosis; amino acid sequence; non-synonymous SNPs; naked neck chickens; single nucleotide polymorphisms (SNPs); nsSNPs. |
| url | https://periodicos.uem.br/ojs/index.php/ActaSciAnimSci/article/view/71608 |
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