Long-term memory plasticity in a decade-long connectivity study post anterior temporal lobe resection
Abstract Approximately 40% of individuals undergoing anterior temporal lobe resection for temporal lobe epilepsy experience episodic memory decline. There has been a focus on early memory network changes; longer-term plasticity and its impact on memory function are unclear. Our study investigates ne...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-55704-x |
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| author | Marine N. Fleury Lawrence P. Binding Peter Taylor Fenglai Xiao Davide Giampiccolo Sarah Buck Gavin P. Winston Pamela J. Thompson Sallie Baxendale Andrew W. McEvoy Matthias J. Koepp John S. Duncan Meneka K. Sidhu |
| author_facet | Marine N. Fleury Lawrence P. Binding Peter Taylor Fenglai Xiao Davide Giampiccolo Sarah Buck Gavin P. Winston Pamela J. Thompson Sallie Baxendale Andrew W. McEvoy Matthias J. Koepp John S. Duncan Meneka K. Sidhu |
| author_sort | Marine N. Fleury |
| collection | DOAJ |
| description | Abstract Approximately 40% of individuals undergoing anterior temporal lobe resection for temporal lobe epilepsy experience episodic memory decline. There has been a focus on early memory network changes; longer-term plasticity and its impact on memory function are unclear. Our study investigates neural mechanisms of memory recovery and network plasticity over nearly a decade post-surgery. We assess memory network changes, from 3–12 months to 10 years postoperatively, in 25 patients (12 left-sided resections) relative to 10 healthy matched controls, using longitudinal task-based functional MRI and standard neuropsychology assessments. We observe key adaptive changes in memory networks of a predominantly seizure-free cohort. Ongoing neuroplasticity in posterior medial temporal regions and contralesional cingulum or pallidum contribute to long-term verbal and visual memory recovery. Here, we show the potential for sustained cognitive improvement and importance of strategic approaches in epilepsy treatment, advocating for conservative surgeries and long-term use of cognitive rehabilitation for ongoing recovery. |
| format | Article |
| id | doaj-art-395cac99c6a247f3936a2c8a9afd824e |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-395cac99c6a247f3936a2c8a9afd824e2025-01-19T12:32:19ZengNature PortfolioNature Communications2041-17232025-01-0116111710.1038/s41467-024-55704-xLong-term memory plasticity in a decade-long connectivity study post anterior temporal lobe resectionMarine N. Fleury0Lawrence P. Binding1Peter Taylor2Fenglai Xiao3Davide Giampiccolo4Sarah Buck5Gavin P. Winston6Pamela J. Thompson7Sallie Baxendale8Andrew W. McEvoy9Matthias J. Koepp10John S. Duncan11Meneka K. Sidhu12Department of Clinical and Experimental Epilepsy, Queen Square Institute of Neurology, UCLDepartment of Clinical and Experimental Epilepsy, Queen Square Institute of Neurology, UCLDepartment of Clinical and Experimental Epilepsy, Queen Square Institute of Neurology, UCLDepartment of Clinical and Experimental Epilepsy, Queen Square Institute of Neurology, UCLDepartment of Clinical and Experimental Epilepsy, Queen Square Institute of Neurology, UCLDepartment of Clinical and Experimental Epilepsy, Queen Square Institute of Neurology, UCLDepartment of Clinical and Experimental Epilepsy, Queen Square Institute of Neurology, UCLDepartment of Clinical and Experimental Epilepsy, Queen Square Institute of Neurology, UCLDepartment of Clinical and Experimental Epilepsy, Queen Square Institute of Neurology, UCLDepartment of Clinical and Experimental Epilepsy, Queen Square Institute of Neurology, UCLDepartment of Clinical and Experimental Epilepsy, Queen Square Institute of Neurology, UCLDepartment of Clinical and Experimental Epilepsy, Queen Square Institute of Neurology, UCLDepartment of Clinical and Experimental Epilepsy, Queen Square Institute of Neurology, UCLAbstract Approximately 40% of individuals undergoing anterior temporal lobe resection for temporal lobe epilepsy experience episodic memory decline. There has been a focus on early memory network changes; longer-term plasticity and its impact on memory function are unclear. Our study investigates neural mechanisms of memory recovery and network plasticity over nearly a decade post-surgery. We assess memory network changes, from 3–12 months to 10 years postoperatively, in 25 patients (12 left-sided resections) relative to 10 healthy matched controls, using longitudinal task-based functional MRI and standard neuropsychology assessments. We observe key adaptive changes in memory networks of a predominantly seizure-free cohort. Ongoing neuroplasticity in posterior medial temporal regions and contralesional cingulum or pallidum contribute to long-term verbal and visual memory recovery. Here, we show the potential for sustained cognitive improvement and importance of strategic approaches in epilepsy treatment, advocating for conservative surgeries and long-term use of cognitive rehabilitation for ongoing recovery.https://doi.org/10.1038/s41467-024-55704-x |
| spellingShingle | Marine N. Fleury Lawrence P. Binding Peter Taylor Fenglai Xiao Davide Giampiccolo Sarah Buck Gavin P. Winston Pamela J. Thompson Sallie Baxendale Andrew W. McEvoy Matthias J. Koepp John S. Duncan Meneka K. Sidhu Long-term memory plasticity in a decade-long connectivity study post anterior temporal lobe resection Nature Communications |
| title | Long-term memory plasticity in a decade-long connectivity study post anterior temporal lobe resection |
| title_full | Long-term memory plasticity in a decade-long connectivity study post anterior temporal lobe resection |
| title_fullStr | Long-term memory plasticity in a decade-long connectivity study post anterior temporal lobe resection |
| title_full_unstemmed | Long-term memory plasticity in a decade-long connectivity study post anterior temporal lobe resection |
| title_short | Long-term memory plasticity in a decade-long connectivity study post anterior temporal lobe resection |
| title_sort | long term memory plasticity in a decade long connectivity study post anterior temporal lobe resection |
| url | https://doi.org/10.1038/s41467-024-55704-x |
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