Higher mortality in stroke patients with active COVID-19 infection
Aim: Our previous research (Abstract, J Vessels Circ. 2021;2) suggested an increased risk of thrombotic events, including ischemic strokes, in patients with COVID-19. This study aims to determine the mortality rate and its predictors in patients with stroke and concurrent COVID-19 infection. Methods...
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| Format: | Article |
| Language: | English |
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Open Exploration Publishing Inc.
2025-06-01
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| Series: | Exploration of Neuroprotective Therapy |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A1004109/1004109.pdf |
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| author | Mostafa Almasi-Dooghaee Seyedehnarges Tabatabaee Fatemeh Moghadas Tara Khoeini Mona Ramezani Ghamsari Tayebeh Lotfi Matineh Heidari Zakieh Shafiei Roya Yazdani Zahra Mirzaasgari Seyed Mohammad Tabatabaei Mehdi Moghaddasi Abdol-Hossein Vahabie |
| author_facet | Mostafa Almasi-Dooghaee Seyedehnarges Tabatabaee Fatemeh Moghadas Tara Khoeini Mona Ramezani Ghamsari Tayebeh Lotfi Matineh Heidari Zakieh Shafiei Roya Yazdani Zahra Mirzaasgari Seyed Mohammad Tabatabaei Mehdi Moghaddasi Abdol-Hossein Vahabie |
| author_sort | Mostafa Almasi-Dooghaee |
| collection | DOAJ |
| description | Aim: Our previous research (Abstract, J Vessels Circ. 2021;2) suggested an increased risk of thrombotic events, including ischemic strokes, in patients with COVID-19. This study aims to determine the mortality rate and its predictors in patients with stroke and concurrent COVID-19 infection. Methods: A retrospective analysis was conducted on stroke patients admitted to three Iranian referral hospitals within a 3-month period during the COVID-19 pandemic (COV-pos and COV-neg groups). The mortality rate was compared to a similar period one year before the pandemic (non-COV group). The Cox proportional hazards model was used to assess the independent and interactive effects of various variables on mortality. Results: Among 124 stroke admissions, 59 (47.6%) had confirmed COVID-19 infection. The COV-pos group had a significantly higher initial NIHSS score (P = 0.001) compared to other groups. Mortality rates were 49.2%, 24.2%, and 17.3% in the COV-pos, COV-neg, and non-COV groups, respectively (P < 0.001). Posterior cerebral artery (PCA) stroke (HR = 65.099), internal carotid artery (ICA) stroke (HR = 19.102), and a history of diabetes mellitus (HR = 3.824) were identified as the most significant predictors of mortality in patients with stroke and COVID-19 infection. Conclusions: Stroke patients with COVID-19 infection exhibited a significantly higher mortality rate compared to patients without COVID-19. The type of stroke involving the PCA or ICA and a history of diabetes emerged as the strongest predictors of mortality in the studied population. |
| format | Article |
| id | doaj-art-395b16ffdb894fc097fc0d365efc7e7a |
| institution | Kabale University |
| issn | 2769-6510 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Neuroprotective Therapy |
| spelling | doaj-art-395b16ffdb894fc097fc0d365efc7e7a2025-08-20T03:32:20ZengOpen Exploration Publishing Inc.Exploration of Neuroprotective Therapy2769-65102025-06-015100410910.37349/ent.2025.1004109Higher mortality in stroke patients with active COVID-19 infectionMostafa Almasi-Dooghaee0Seyedehnarges Tabatabaee1https://orcid.org/0000-0001-8717-8757Fatemeh Moghadas2Tara Khoeini3Mona Ramezani Ghamsari4Tayebeh Lotfi5Matineh Heidari6Zakieh Shafiei7Roya Yazdani8Zahra Mirzaasgari9Seyed Mohammad Tabatabaei10Mehdi Moghaddasi11Abdol-Hossein Vahabie12Department of Neurology, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran 1911883611, Iran; Rasoul Akram Clinical Research Development Unit (RACRD), Iran University of Medical Sciences, Tehran 1981685113, IranDepartment of Neurology, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran 1911883611, IranRasoul Akram Clinical Research Development Unit (RACRD), Iran University of Medical Sciences, Tehran 1981685113, Iran; Department of Neurology, Rasoul Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran 1981685113, IranDepartment of Neurology, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran 1911883611, IranRasoul Akram Clinical Research Development Unit (RACRD), Iran University of Medical Sciences, Tehran 1981685113, Iran; Clinical Research Development Center of Shahid Rajaei, Alborz University of Medical Sciences, Karaj 3154686695, IranRasoul Akram Clinical Research Development Unit (RACRD), Iran University of Medical Sciences, Tehran 1981685113, Iran; Department of Neurology, Rasoul Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran 1981685113, IranDepartment of Neurology, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran 1911883611, IranDepartment of Neurology, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran 1911883611, IranDepartment of Neurology, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran 1911883611, IranDepartment of Neurology, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran 1911883611, Iran; Rasoul Akram Clinical Research Development Unit (RACRD), Iran University of Medical Sciences, Tehran 1981685113, IranDepartment of Electrical and Computer Engineering, University of Tehran, Tehran 1914395515, IranDepartment of Neurology, Rasoul Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran 1981685113, IranCognitive Systems Laboratory, Control and Intelligent Processing Center of Excellence (CIPCE), School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran 1914395515, Iran; Department of Psychology, Faculty of Psychology and Education, University of Tehran, Tehran 1941556456, Iran; School of Cognitive Sciences, Institute for Research in Fundamental Sciences, Tehran 1953833511, IranAim: Our previous research (Abstract, J Vessels Circ. 2021;2) suggested an increased risk of thrombotic events, including ischemic strokes, in patients with COVID-19. This study aims to determine the mortality rate and its predictors in patients with stroke and concurrent COVID-19 infection. Methods: A retrospective analysis was conducted on stroke patients admitted to three Iranian referral hospitals within a 3-month period during the COVID-19 pandemic (COV-pos and COV-neg groups). The mortality rate was compared to a similar period one year before the pandemic (non-COV group). The Cox proportional hazards model was used to assess the independent and interactive effects of various variables on mortality. Results: Among 124 stroke admissions, 59 (47.6%) had confirmed COVID-19 infection. The COV-pos group had a significantly higher initial NIHSS score (P = 0.001) compared to other groups. Mortality rates were 49.2%, 24.2%, and 17.3% in the COV-pos, COV-neg, and non-COV groups, respectively (P < 0.001). Posterior cerebral artery (PCA) stroke (HR = 65.099), internal carotid artery (ICA) stroke (HR = 19.102), and a history of diabetes mellitus (HR = 3.824) were identified as the most significant predictors of mortality in patients with stroke and COVID-19 infection. Conclusions: Stroke patients with COVID-19 infection exhibited a significantly higher mortality rate compared to patients without COVID-19. The type of stroke involving the PCA or ICA and a history of diabetes emerged as the strongest predictors of mortality in the studied population.https://www.explorationpub.com/uploads/Article/A1004109/1004109.pdfcovid-19 infectionpandemicsstrokemortality |
| spellingShingle | Mostafa Almasi-Dooghaee Seyedehnarges Tabatabaee Fatemeh Moghadas Tara Khoeini Mona Ramezani Ghamsari Tayebeh Lotfi Matineh Heidari Zakieh Shafiei Roya Yazdani Zahra Mirzaasgari Seyed Mohammad Tabatabaei Mehdi Moghaddasi Abdol-Hossein Vahabie Higher mortality in stroke patients with active COVID-19 infection Exploration of Neuroprotective Therapy covid-19 infection pandemics stroke mortality |
| title | Higher mortality in stroke patients with active COVID-19 infection |
| title_full | Higher mortality in stroke patients with active COVID-19 infection |
| title_fullStr | Higher mortality in stroke patients with active COVID-19 infection |
| title_full_unstemmed | Higher mortality in stroke patients with active COVID-19 infection |
| title_short | Higher mortality in stroke patients with active COVID-19 infection |
| title_sort | higher mortality in stroke patients with active covid 19 infection |
| topic | covid-19 infection pandemics stroke mortality |
| url | https://www.explorationpub.com/uploads/Article/A1004109/1004109.pdf |
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