Guar gum-modified magnetic palladium nanocatalyst: C–N coupling reaction and STAT3-Mediated breast cancer therapy
The present study explains the unmoved synthesis of Pd nanoparticle-decorated guar gum utilized as Fe3O4 NPs (Fe3O4@guar gum/Pd NPs), the resultant catalytic and biological applications within the context of an eco-friendly procedure. FT-IR, FE-SEM, TEM, EDS, and so on are some of the methods applie...
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Elsevier
2025-06-01
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| Series: | Journal of Science: Advanced Materials and Devices |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S246821792500005X |
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| author | Junrui Luan Xin Dong Shuwen Zhou |
| author_facet | Junrui Luan Xin Dong Shuwen Zhou |
| author_sort | Junrui Luan |
| collection | DOAJ |
| description | The present study explains the unmoved synthesis of Pd nanoparticle-decorated guar gum utilized as Fe3O4 NPs (Fe3O4@guar gum/Pd NPs), the resultant catalytic and biological applications within the context of an eco-friendly procedure. FT-IR, FE-SEM, TEM, EDS, and so on are some of the methods applied to evaluate the constructional and physicochemical features of such an unequaled substance. After the characterization of the process, we successfully used the prepared Fe3O4@guar gum/Pd NPs in the N-arylation of indole across C(aryl)-N bond formation from the pertaining haloarens (I, Br, Cl) through Ullmann-type coupling reactions. In addition, the new accelerator bears the ability to be recuperated and recycled 7 times. The MTT test was then used to investigate the extent to which Fe3O4@guar gum/Pd NP-treated cells suppressed human breast cancer. Healthy (HUVEC) and breast cancer cells, specifically MCF-10, were used for the evaluation. The Fe3O4@guar gum/Pd NPs showed an IC50 value of 62 μg/mL against MCF-10, respectively. The presence of the material resulted in a 40–50% induction of cell apoptosis, along with down regulation of the anti-apoptotic marker. Finally, the Fe3O4@guar gum/Pd NPs showed suppressive properties on colony formation. According to our research, the Fe3O4@guar gum/Pd NPs can decrease STAT3 expression in the treated cells while increasing p53 levels. The effect of Fe3O4@guar gum/Pd NPs on human breast cancer cells demonstrates how important p53 and STAT3 are to the ensuing biological consequences. According to these findings, Fe3O4@guar gum/Pd NPs have a lot of promise as a therapy for human breast cancer cells. |
| format | Article |
| id | doaj-art-3959be59aa414930804e84278f5d3fa2 |
| institution | Kabale University |
| issn | 2468-2179 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
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| series | Journal of Science: Advanced Materials and Devices |
| spelling | doaj-art-3959be59aa414930804e84278f5d3fa22025-02-07T04:48:00ZengElsevierJournal of Science: Advanced Materials and Devices2468-21792025-06-01102100852Guar gum-modified magnetic palladium nanocatalyst: C–N coupling reaction and STAT3-Mediated breast cancer therapyJunrui Luan0Xin Dong1Shuwen Zhou2School of Pharmacy & School of Biological and Food Engineering, Changzhou University, School of Pharmacy Building, 520 Avenue, Science and Education City, Wujin District, 213164, Changzhou City, Jiangsu Province, China; Department of Pharmacy, Qingdao Massage Rehabilitation Hospital, No.8 Zhiquan Road, Shinan District, 266071, Qingdao, Shandong Province, ChinaDepartment of Pharmacy, Qingdao Traditional Chinese Medicine Hospital, Qingdao Hiser Hospital Affiliated of Qingdao University, No.4 Renmin Road, Shibei District, 266034, Qingdao, ChinaSchool of Pharmacy & School of Biological and Food Engineering, Changzhou University, School of Pharmacy Building, 520 Avenue, Science and Education City, Wujin District, 213164, Changzhou City, Jiangsu Province, China; Corresponding author.The present study explains the unmoved synthesis of Pd nanoparticle-decorated guar gum utilized as Fe3O4 NPs (Fe3O4@guar gum/Pd NPs), the resultant catalytic and biological applications within the context of an eco-friendly procedure. FT-IR, FE-SEM, TEM, EDS, and so on are some of the methods applied to evaluate the constructional and physicochemical features of such an unequaled substance. After the characterization of the process, we successfully used the prepared Fe3O4@guar gum/Pd NPs in the N-arylation of indole across C(aryl)-N bond formation from the pertaining haloarens (I, Br, Cl) through Ullmann-type coupling reactions. In addition, the new accelerator bears the ability to be recuperated and recycled 7 times. The MTT test was then used to investigate the extent to which Fe3O4@guar gum/Pd NP-treated cells suppressed human breast cancer. Healthy (HUVEC) and breast cancer cells, specifically MCF-10, were used for the evaluation. The Fe3O4@guar gum/Pd NPs showed an IC50 value of 62 μg/mL against MCF-10, respectively. The presence of the material resulted in a 40–50% induction of cell apoptosis, along with down regulation of the anti-apoptotic marker. Finally, the Fe3O4@guar gum/Pd NPs showed suppressive properties on colony formation. According to our research, the Fe3O4@guar gum/Pd NPs can decrease STAT3 expression in the treated cells while increasing p53 levels. The effect of Fe3O4@guar gum/Pd NPs on human breast cancer cells demonstrates how important p53 and STAT3 are to the ensuing biological consequences. According to these findings, Fe3O4@guar gum/Pd NPs have a lot of promise as a therapy for human breast cancer cells.http://www.sciencedirect.com/science/article/pii/S246821792500005XGuar gumPalladium nanoparticlesC(aryl)-N couplingIndoleBreast cancerSignaling pathways |
| spellingShingle | Junrui Luan Xin Dong Shuwen Zhou Guar gum-modified magnetic palladium nanocatalyst: C–N coupling reaction and STAT3-Mediated breast cancer therapy Journal of Science: Advanced Materials and Devices Guar gum Palladium nanoparticles C(aryl)-N coupling Indole Breast cancer Signaling pathways |
| title | Guar gum-modified magnetic palladium nanocatalyst: C–N coupling reaction and STAT3-Mediated breast cancer therapy |
| title_full | Guar gum-modified magnetic palladium nanocatalyst: C–N coupling reaction and STAT3-Mediated breast cancer therapy |
| title_fullStr | Guar gum-modified magnetic palladium nanocatalyst: C–N coupling reaction and STAT3-Mediated breast cancer therapy |
| title_full_unstemmed | Guar gum-modified magnetic palladium nanocatalyst: C–N coupling reaction and STAT3-Mediated breast cancer therapy |
| title_short | Guar gum-modified magnetic palladium nanocatalyst: C–N coupling reaction and STAT3-Mediated breast cancer therapy |
| title_sort | guar gum modified magnetic palladium nanocatalyst c n coupling reaction and stat3 mediated breast cancer therapy |
| topic | Guar gum Palladium nanoparticles C(aryl)-N coupling Indole Breast cancer Signaling pathways |
| url | http://www.sciencedirect.com/science/article/pii/S246821792500005X |
| work_keys_str_mv | AT junruiluan guargummodifiedmagneticpalladiumnanocatalystcncouplingreactionandstat3mediatedbreastcancertherapy AT xindong guargummodifiedmagneticpalladiumnanocatalystcncouplingreactionandstat3mediatedbreastcancertherapy AT shuwenzhou guargummodifiedmagneticpalladiumnanocatalystcncouplingreactionandstat3mediatedbreastcancertherapy |