Antibacterial Methyl Ester Cembranoids from the Soft Coral <i>Sarcophyton ehrenbergi</i> and Their Structural Elucidation
Six previously undescribed methyl ester cembranoids, namely sarcoehrenolides L–Q (<b>1</b>–<b>6</b>), along with three known related ones (<b>7</b>–<b>9</b>), were isolated from the soft coral <i>Sarcophyton ehrenbergi</i> collected off Wei...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/23/4/170 |
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| Summary: | Six previously undescribed methyl ester cembranoids, namely sarcoehrenolides L–Q (<b>1</b>–<b>6</b>), along with three known related ones (<b>7</b>–<b>9</b>), were isolated from the soft coral <i>Sarcophyton ehrenbergi</i> collected off Weizhou Island in the South China Sea. Their structures and absolute configurations were unambiguously established in the light of extensive spectroscopic data analysis, X-ray diffraction analysis, chemical conversion, and TDDFT-ECD calculations. All isolated compounds were evaluated via in vitro bioassays to investigate their antibacterial activity against eighteen human and fish pathogens. Compounds <b>2</b>, <b>8</b>, and <b>9</b> exhibited moderate antibacterial activity against <i>Streptococcus parauberis</i> with MIC values of 38.8, 37.4 and 31.6 μg/mL, respectively. |
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| ISSN: | 1660-3397 |