Prospects for Using 3D Modeling and Biomarkers in Differential Diagnosis of Endometrioid Ovarian Cysts
Background. Ovarian heterotopias are quite successfully diagnosed with ultrasound examinations. Considering the high risk of spread of the disease, as well as reproductive consequences (infertility, pelvic adhesive processes, chronic pelvic pain syndrome, dysmenorrhea), early differential diagnosis...
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Luchevaya Diagnostika, LLC
2024-06-01
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| Series: | Вестник рентгенологии и радиологии |
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| Online Access: | https://www.russianradiology.ru/jour/article/view/852 |
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| author | Е. М. Blazhnova R. B. Balter Т. V. Ivanova Т. А. Pugacheva А. R. Ibragimova L. S. Tselkovich А. Т. Oganisyan |
| author_facet | Е. М. Blazhnova R. B. Balter Т. V. Ivanova Т. А. Pugacheva А. R. Ibragimova L. S. Tselkovich А. Т. Oganisyan |
| author_sort | Е. М. Blazhnova |
| collection | DOAJ |
| description | Background. Ovarian heterotopias are quite successfully diagnosed with ultrasound examinations. Considering the high risk of spread of the disease, as well as reproductive consequences (infertility, pelvic adhesive processes, chronic pelvic pain syndrome, dysmenorrhea), early differential diagnosis of endometrioid cysts and, accordingly, early initiation of treatment are of particular importance.Objective: to combine ultrasound criteria using 3D visualization and the content of biomarkers to verify stage 1–2 endometrioid ovarian cysts.Material and methods. In 59 infertile women with endometrioid ovarian cysts, in the dynamics of the menstrual cycle, ultrasound examinations were performed using Acuson S2000 (Siemens, Germany) and Voluson E8 (General Electric, USA) with the possibility of Doppler measurements and three-dimensional reconstruction of tissue images. Also, in laboratories “Invitro”, “Hemotest”, “Nauka” (Samara, Russia) the biomarkers were determined: interleukins IL-1β, IL-6, cancer antigen 125 (CA-125), human epididymis protein 4 (HE4) and the index by Risk of Ovarian Malignancy Algorithm (ROMA). The control group included 195 fertile women of reproductive age. In patients with endometrioid cysts, the diagnosis was subsequently confirmed morphologically.Results. Small unilateral and bilateral ovarian cysts corresponding to stage 1–2 endometriosis by revised American Fertility Society classification (rAFS) were clearly differentiated in 56 (94.9%) patients, in 3 (5.4%) of them the ultrasound result was questionable. In 48 (81.4%) women the lesion was unilateral and in 11 (18.6%) it was bilateral. The structure of cystic formations in all cases was hypoechoic, heterogeneous, in 36 (61.0%) cases it was finely cellular, without blood flow.Conclusion. Ovarian endometriomas in “gray scale” are round formations of reduced echogenicity and fine suspension, with an even, clear contour, not fused with the surrounding tissues, avascular, changing size depending on menstrual cycle phase. An ovarian mass may have a capsule with locus signals on Doppler. The sensitivity of ultrasound examination in “gray scale” in the presence of an endometrioid cyst is 94.6%. |
| format | Article |
| id | doaj-art-3952f157c3f8468791a7fd1871ff6a41 |
| institution | Kabale University |
| issn | 0042-4676 2619-0478 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Luchevaya Diagnostika, LLC |
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| spelling | doaj-art-3952f157c3f8468791a7fd1871ff6a412025-08-20T03:58:45ZengLuchevaya Diagnostika, LLCВестник рентгенологии и радиологии0042-46762619-04782024-06-01105161210.20862/0042-4676-2024-105-1-6-12456Prospects for Using 3D Modeling and Biomarkers in Differential Diagnosis of Endometrioid Ovarian CystsЕ. М. Blazhnova0R. B. Balter1Т. V. Ivanova2Т. А. Pugacheva3А. R. Ibragimova4L. S. Tselkovich5А. Т. Oganisyan6Samara State Medical University; Russian Railways-Medicine LLCSamara State Medical UniversitySamara State Medical UniversitySamara State Medical UniversitySamara State Medical UniversitySamara State Medical UniversitySamara State Medical UniversityBackground. Ovarian heterotopias are quite successfully diagnosed with ultrasound examinations. Considering the high risk of spread of the disease, as well as reproductive consequences (infertility, pelvic adhesive processes, chronic pelvic pain syndrome, dysmenorrhea), early differential diagnosis of endometrioid cysts and, accordingly, early initiation of treatment are of particular importance.Objective: to combine ultrasound criteria using 3D visualization and the content of biomarkers to verify stage 1–2 endometrioid ovarian cysts.Material and methods. In 59 infertile women with endometrioid ovarian cysts, in the dynamics of the menstrual cycle, ultrasound examinations were performed using Acuson S2000 (Siemens, Germany) and Voluson E8 (General Electric, USA) with the possibility of Doppler measurements and three-dimensional reconstruction of tissue images. Also, in laboratories “Invitro”, “Hemotest”, “Nauka” (Samara, Russia) the biomarkers were determined: interleukins IL-1β, IL-6, cancer antigen 125 (CA-125), human epididymis protein 4 (HE4) and the index by Risk of Ovarian Malignancy Algorithm (ROMA). The control group included 195 fertile women of reproductive age. In patients with endometrioid cysts, the diagnosis was subsequently confirmed morphologically.Results. Small unilateral and bilateral ovarian cysts corresponding to stage 1–2 endometriosis by revised American Fertility Society classification (rAFS) were clearly differentiated in 56 (94.9%) patients, in 3 (5.4%) of them the ultrasound result was questionable. In 48 (81.4%) women the lesion was unilateral and in 11 (18.6%) it was bilateral. The structure of cystic formations in all cases was hypoechoic, heterogeneous, in 36 (61.0%) cases it was finely cellular, without blood flow.Conclusion. Ovarian endometriomas in “gray scale” are round formations of reduced echogenicity and fine suspension, with an even, clear contour, not fused with the surrounding tissues, avascular, changing size depending on menstrual cycle phase. An ovarian mass may have a capsule with locus signals on Doppler. The sensitivity of ultrasound examination in “gray scale” in the presence of an endometrioid cyst is 94.6%.https://www.russianradiology.ru/jour/article/view/852endometrioid ovarian cystultrasound examination3d visualizationbiomarkersinterleukins |
| spellingShingle | Е. М. Blazhnova R. B. Balter Т. V. Ivanova Т. А. Pugacheva А. R. Ibragimova L. S. Tselkovich А. Т. Oganisyan Prospects for Using 3D Modeling and Biomarkers in Differential Diagnosis of Endometrioid Ovarian Cysts Вестник рентгенологии и радиологии endometrioid ovarian cyst ultrasound examination 3d visualization biomarkers interleukins |
| title | Prospects for Using 3D Modeling and Biomarkers in Differential Diagnosis of Endometrioid Ovarian Cysts |
| title_full | Prospects for Using 3D Modeling and Biomarkers in Differential Diagnosis of Endometrioid Ovarian Cysts |
| title_fullStr | Prospects for Using 3D Modeling and Biomarkers in Differential Diagnosis of Endometrioid Ovarian Cysts |
| title_full_unstemmed | Prospects for Using 3D Modeling and Biomarkers in Differential Diagnosis of Endometrioid Ovarian Cysts |
| title_short | Prospects for Using 3D Modeling and Biomarkers in Differential Diagnosis of Endometrioid Ovarian Cysts |
| title_sort | prospects for using 3d modeling and biomarkers in differential diagnosis of endometrioid ovarian cysts |
| topic | endometrioid ovarian cyst ultrasound examination 3d visualization biomarkers interleukins |
| url | https://www.russianradiology.ru/jour/article/view/852 |
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