Synthesis, Characterization, and Anticancer Activity of New Metal Complexes Derived from 2-Hydroxy-3-(hydroxyimino)-4-oxopentan-2-ylidene)benzohydrazide
Novel metal(II) complexes derived from 2-hydroxy-N′-((Z)-3-(hydroxyimino)-4-oxopentan-2-ylidene)benzohydrazide ligand (H2L) were synthesized and characterized by elemental and thermal analyses (DTA and TGA), IR, UV-VIS, 1H-NMR, ESR and mass spectroscopy, magnetic susceptibilities, and conductivities...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2015/126023 |
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| author | Abdou Saad El-Tabl Moshira Mohamed Abd El-Waheed Mohammed Ahmed Wahba Nahla Abd El-Halim Abou El-Fadl |
| author_facet | Abdou Saad El-Tabl Moshira Mohamed Abd El-Waheed Mohammed Ahmed Wahba Nahla Abd El-Halim Abou El-Fadl |
| author_sort | Abdou Saad El-Tabl |
| collection | DOAJ |
| description | Novel metal(II) complexes derived from 2-hydroxy-N′-((Z)-3-(hydroxyimino)-4-oxopentan-2-ylidene)benzohydrazide ligand (H2L) were synthesized and characterized by elemental and thermal analyses (DTA and TGA), IR, UV-VIS, 1H-NMR, ESR and mass spectroscopy, magnetic susceptibilities, and conductivities measurements. The complexes adopt distorted octahedral geometry. The ESR spectra of the solid copper(II) complexes are characteristic to d9 configuration and have an axial symmetry type of a d(x2-y2) ground state. The g values confirmed the tetragonal octahedral geometry with a considerably ionic or covalent environment. The cytotoxic activity of the ligand and its metal complexes showed potent cytotoxicity effect against growth of human liver cancer HepG2 cell lines compared to the clinically used Sorafenib (Nexavar). |
| format | Article |
| id | doaj-art-394aa0fd691347b791582277bf0c4cc6 |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-394aa0fd691347b791582277bf0c4cc62025-02-03T05:43:36ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2015-01-01201510.1155/2015/126023126023Synthesis, Characterization, and Anticancer Activity of New Metal Complexes Derived from 2-Hydroxy-3-(hydroxyimino)-4-oxopentan-2-ylidene)benzohydrazideAbdou Saad El-Tabl0Moshira Mohamed Abd El-Waheed1Mohammed Ahmed Wahba2Nahla Abd El-Halim Abou El-Fadl3Department of Chemistry, Faculty of Science, Menoufia University, P.O. Box 5744, Shibin Al Kawm, EgyptDepartment of Pathology, Faculty of Medicine, Menoufia University, P.O. Box 5744, Shibin Al Kawm, EgyptInorganic Chemistry Department, National Research Centre, Dokki, Cairo 12311, EgyptDepartment of Chemistry, Faculty of Science, Menoufia University, P.O. Box 5744, Shibin Al Kawm, EgyptNovel metal(II) complexes derived from 2-hydroxy-N′-((Z)-3-(hydroxyimino)-4-oxopentan-2-ylidene)benzohydrazide ligand (H2L) were synthesized and characterized by elemental and thermal analyses (DTA and TGA), IR, UV-VIS, 1H-NMR, ESR and mass spectroscopy, magnetic susceptibilities, and conductivities measurements. The complexes adopt distorted octahedral geometry. The ESR spectra of the solid copper(II) complexes are characteristic to d9 configuration and have an axial symmetry type of a d(x2-y2) ground state. The g values confirmed the tetragonal octahedral geometry with a considerably ionic or covalent environment. The cytotoxic activity of the ligand and its metal complexes showed potent cytotoxicity effect against growth of human liver cancer HepG2 cell lines compared to the clinically used Sorafenib (Nexavar).http://dx.doi.org/10.1155/2015/126023 |
| spellingShingle | Abdou Saad El-Tabl Moshira Mohamed Abd El-Waheed Mohammed Ahmed Wahba Nahla Abd El-Halim Abou El-Fadl Synthesis, Characterization, and Anticancer Activity of New Metal Complexes Derived from 2-Hydroxy-3-(hydroxyimino)-4-oxopentan-2-ylidene)benzohydrazide Bioinorganic Chemistry and Applications |
| title | Synthesis, Characterization, and Anticancer Activity of New Metal Complexes Derived from 2-Hydroxy-3-(hydroxyimino)-4-oxopentan-2-ylidene)benzohydrazide |
| title_full | Synthesis, Characterization, and Anticancer Activity of New Metal Complexes Derived from 2-Hydroxy-3-(hydroxyimino)-4-oxopentan-2-ylidene)benzohydrazide |
| title_fullStr | Synthesis, Characterization, and Anticancer Activity of New Metal Complexes Derived from 2-Hydroxy-3-(hydroxyimino)-4-oxopentan-2-ylidene)benzohydrazide |
| title_full_unstemmed | Synthesis, Characterization, and Anticancer Activity of New Metal Complexes Derived from 2-Hydroxy-3-(hydroxyimino)-4-oxopentan-2-ylidene)benzohydrazide |
| title_short | Synthesis, Characterization, and Anticancer Activity of New Metal Complexes Derived from 2-Hydroxy-3-(hydroxyimino)-4-oxopentan-2-ylidene)benzohydrazide |
| title_sort | synthesis characterization and anticancer activity of new metal complexes derived from 2 hydroxy 3 hydroxyimino 4 oxopentan 2 ylidene benzohydrazide |
| url | http://dx.doi.org/10.1155/2015/126023 |
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