Antibacterial activity, quality and stability study of creams with new potential silver(I) complexes and in vivo case report
The aim of this study was to evaluate the antibacterial activity, quality and stability of creams (at 1 % concentration) prepared with synthesized silver(I) complexes: [Ag(Nam)2]NO3·H2O ( AgNam), [Ag2(HGly)2]n(NO3)2n (AgGly) (Nam – nicotin-amide, Gly – glycine) and silver(I) sulfadiazine (AgSD), whi...
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| Format: | Article |
| Language: | English |
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2023-06-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2023-0011 |
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| author | Sovová Simona Megyesi Štefánia Laca Mudroňová Dagmar Mudroň Pavol Harvanová Jarmila Rendošová Michaela Goga Michal Tkáčiková Ľudmila Vargová Zuzana |
| author_facet | Sovová Simona Megyesi Štefánia Laca Mudroňová Dagmar Mudroň Pavol Harvanová Jarmila Rendošová Michaela Goga Michal Tkáčiková Ľudmila Vargová Zuzana |
| author_sort | Sovová Simona |
| collection | DOAJ |
| description | The aim of this study was to evaluate the antibacterial activity, quality and stability of creams (at 1 % concentration) prepared with synthesized silver(I) complexes: [Ag(Nam)2]NO3·H2O ( AgNam), [Ag2(HGly)2]n(NO3)2n (AgGly) (Nam – nicotin-amide, Gly – glycine) and silver(I) sulfadiazine (AgSD), which is commercially available. Antibacterial activity was evaluated by agar well diffusion method and in in vivo case. The pure silver(I) complexes as well as all three tested creams loaded with AgGly, AgSD and AgNam showed antibacterial potential. Moreover, the creams loaded with AgGly and AgNam showed higher antibacterial effects against S. aureus and B. subtilis than the cream loaded with AgSD. In terms of appearance, all cream samples were opaque and odourless, and no phase separation was observed. Creams were soluble in water (o/w emulsions) and they had a pseudoplastic behaviour. The pH of the creams was in the range of 4.87–5.75. No visible changes were observed in the case of commercially used AgSD cream during one month testing period at conditions –16 ± 1 °C; 6 ± 1 °C and 56 % relative humidity; 20 ± 1 °C and 58 % relative humidity and 40 ± 1 °C and 75 % relative humidity. However, creams containing AgGly and AgNam changed their colour depending on the tested conditions. |
| format | Article |
| id | doaj-art-3943b2620df241148bdab8fd9ce147e8 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-3943b2620df241148bdab8fd9ce147e82025-02-03T08:17:11ZengSciendoActa Pharmaceutica1846-95582023-06-0173231132310.2478/acph-2023-0011Antibacterial activity, quality and stability study of creams with new potential silver(I) complexes and in vivo case reportSovová Simona0Megyesi Štefánia Laca1Mudroňová Dagmar2Mudroň Pavol3Harvanová Jarmila4Rendošová Michaela5Goga Michal6Tkáčiková Ľudmila7Vargová Zuzana81Department of Pharmaceutical Technology Pharmacognosy and Botany, University of Veterinary Medicine and Pharmacy, 041 81Košice, Slovak Republic1Department of Pharmaceutical Technology Pharmacognosy and Botany, University of Veterinary Medicine and Pharmacy, 041 81Košice, Slovak Republic3Department of Microbiology and ImmunologyUniversity of Veterinary Medicine and Pharmacy041 81Košice, Slovak Republic4Clinic of Ruminants of the University of Veterinary Medicine and Pharmacy, 041 81Košice, Slovak Republic5Department of Chemistry, Biochemistry and Biophysics, University of Veterinary Medicine and Pharmacy, 041 81Košice, Slovak Republic2Institute of Chemistry, Faculty of Science P. J. Šafárik University, 041 54Košice, Slovak Republic6Department of Botany, Institute of Biology and Ecology, Faculty of Science, P. J. Šafárik University040 01Košice, Slovak Republic3Department of Microbiology and ImmunologyUniversity of Veterinary Medicine and Pharmacy041 81Košice, Slovak Republic2Institute of Chemistry, Faculty of Science P. J. Šafárik University, 041 54Košice, Slovak RepublicThe aim of this study was to evaluate the antibacterial activity, quality and stability of creams (at 1 % concentration) prepared with synthesized silver(I) complexes: [Ag(Nam)2]NO3·H2O ( AgNam), [Ag2(HGly)2]n(NO3)2n (AgGly) (Nam – nicotin-amide, Gly – glycine) and silver(I) sulfadiazine (AgSD), which is commercially available. Antibacterial activity was evaluated by agar well diffusion method and in in vivo case. The pure silver(I) complexes as well as all three tested creams loaded with AgGly, AgSD and AgNam showed antibacterial potential. Moreover, the creams loaded with AgGly and AgNam showed higher antibacterial effects against S. aureus and B. subtilis than the cream loaded with AgSD. In terms of appearance, all cream samples were opaque and odourless, and no phase separation was observed. Creams were soluble in water (o/w emulsions) and they had a pseudoplastic behaviour. The pH of the creams was in the range of 4.87–5.75. No visible changes were observed in the case of commercially used AgSD cream during one month testing period at conditions –16 ± 1 °C; 6 ± 1 °C and 56 % relative humidity; 20 ± 1 °C and 58 % relative humidity and 40 ± 1 °C and 75 % relative humidity. However, creams containing AgGly and AgNam changed their colour depending on the tested conditions.https://doi.org/10.2478/acph-2023-0011silver(i) antimicrobial complexescreamsevaluationantibacterial activitypilot in vivo case report |
| spellingShingle | Sovová Simona Megyesi Štefánia Laca Mudroňová Dagmar Mudroň Pavol Harvanová Jarmila Rendošová Michaela Goga Michal Tkáčiková Ľudmila Vargová Zuzana Antibacterial activity, quality and stability study of creams with new potential silver(I) complexes and in vivo case report Acta Pharmaceutica silver(i) antimicrobial complexes creams evaluation antibacterial activity pilot in vivo case report |
| title | Antibacterial activity, quality and stability study of creams with new potential silver(I) complexes and in vivo case report |
| title_full | Antibacterial activity, quality and stability study of creams with new potential silver(I) complexes and in vivo case report |
| title_fullStr | Antibacterial activity, quality and stability study of creams with new potential silver(I) complexes and in vivo case report |
| title_full_unstemmed | Antibacterial activity, quality and stability study of creams with new potential silver(I) complexes and in vivo case report |
| title_short | Antibacterial activity, quality and stability study of creams with new potential silver(I) complexes and in vivo case report |
| title_sort | antibacterial activity quality and stability study of creams with new potential silver i complexes and in vivo case report |
| topic | silver(i) antimicrobial complexes creams evaluation antibacterial activity pilot in vivo case report |
| url | https://doi.org/10.2478/acph-2023-0011 |
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