Engineering Pseudomonas putida for production of 3-hydroxyacids using hybrid type I polyketide synthases

Engineering Pseudomonas putida for production of 3-hydroxyacids using hybrid type I polyketide synthases

Engineered type I polyketide synthases (T1PKSs) are a potentially transformative platform for the biosynthesis of small molecules. Due to their modular nature, T1PKSs can be rationally designed to produce a wide range of bulk or specialty chemicals. While heterologous PKS expression is best studied...

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Bibliographic Details
Main Authors: Matthias Schmidt, Aaron A. Vilchez, Namil Lee, Leah S. Keiser, Allison N. Pearson, Mitchell G. Thompson, Yolanda Zhu, Robert W. Haushalter, Adam M. Deutschbauer, Satoshi Yuzawa, Lars M. Blank, Jay D. Keasling
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Metabolic Engineering Communications
Subjects:
Pseudomonas putida
Polyketide synthase engineering
3-Hydroxyacid production
Transposon sequencing
Protease degradation tag
Online Access:http://www.sciencedirect.com/science/article/pii/S2214030125000057
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