MicroRNAs as Biomarkers and Therapeutic Targets for Medulloblastomas
Medulloblastomas (MBs) are the most common malignant neoplasms of the central nervous system in children. MB is a persistent disease associated with a high level of morbidity and mortality, thus requiring aggressive therapeutical approaches. Clinical and histological features of tumours are used for...
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| Language: | English |
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Bashkir State Medical University
2020-12-01
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| Series: | Креативная хирургия и онкология |
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| Online Access: | https://www.surgonco.ru/jour/article/view/535 |
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| author | O. A. Beylerli I. F. Gareev A. B. Alyshov V. V. Kudriashov |
| author_facet | O. A. Beylerli I. F. Gareev A. B. Alyshov V. V. Kudriashov |
| author_sort | O. A. Beylerli |
| collection | DOAJ |
| description | Medulloblastomas (MBs) are the most common malignant neoplasms of the central nervous system in children. MB is a persistent disease associated with a high level of morbidity and mortality, thus requiring aggressive therapeutical approaches. Clinical and histological features of tumours are used for their classification and prognosis. Despite significant progress in the study of MB, its molecular basis remains to be fully understood. MicroRNAs (miRNAs) are short noncoding RNAs (ncRNAs) that function as key regulators of various biological processes, including the development, differentiation, metabolism, proliferation and apoptosis of cells. MiRNAs regulate genes at the posttranscriptional level. Aberrant expression of miRNAs correlates with various cancers. This altered expression may result from mutation, methylation, deletion and amplification of miRNA coding regions. In this review, we discuss the role of miRNAs in MB and their potential use in the diagnosis, prognosis and treatment of this malignant tumour. As a fastgrowing field in biomedical sciences, miRNAs studies will revolutionize the treatment of MB. |
| format | Article |
| id | doaj-art-393c36e7c91e4df48b538588dc4544a9 |
| institution | DOAJ |
| issn | 2076-3093 2307-0501 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | Bashkir State Medical University |
| record_format | Article |
| series | Креативная хирургия и онкология |
| spelling | doaj-art-393c36e7c91e4df48b538588dc4544a92025-08-20T03:19:20ZengBashkir State Medical UniversityКреативная хирургия и онкология2076-30932307-05012020-12-0110431131810.24060/2076-3093-2020-10-4-311-318406MicroRNAs as Biomarkers and Therapeutic Targets for MedulloblastomasO. A. Beylerli0I. F. Gareev1A. B. Alyshov2V. V. Kudriashov3Bashkir State Medical UniversityBashkir State Medical UniversityRepublican Cardiology CentreWest China Hospital of Sichuan UniversityMedulloblastomas (MBs) are the most common malignant neoplasms of the central nervous system in children. MB is a persistent disease associated with a high level of morbidity and mortality, thus requiring aggressive therapeutical approaches. Clinical and histological features of tumours are used for their classification and prognosis. Despite significant progress in the study of MB, its molecular basis remains to be fully understood. MicroRNAs (miRNAs) are short noncoding RNAs (ncRNAs) that function as key regulators of various biological processes, including the development, differentiation, metabolism, proliferation and apoptosis of cells. MiRNAs regulate genes at the posttranscriptional level. Aberrant expression of miRNAs correlates with various cancers. This altered expression may result from mutation, methylation, deletion and amplification of miRNA coding regions. In this review, we discuss the role of miRNAs in MB and their potential use in the diagnosis, prognosis and treatment of this malignant tumour. As a fastgrowing field in biomedical sciences, miRNAs studies will revolutionize the treatment of MB.https://www.surgonco.ru/jour/article/view/535medulloblastomamicrornacentral nervous system neoplasmsgenetic heterogeneitybiomarkerscarcinogenesissuppressor genestherapeutic targets |
| spellingShingle | O. A. Beylerli I. F. Gareev A. B. Alyshov V. V. Kudriashov MicroRNAs as Biomarkers and Therapeutic Targets for Medulloblastomas Креативная хирургия и онкология medulloblastoma microrna central nervous system neoplasms genetic heterogeneity biomarkers carcinogenesis suppressor genes therapeutic targets |
| title | MicroRNAs as Biomarkers and Therapeutic Targets for Medulloblastomas |
| title_full | MicroRNAs as Biomarkers and Therapeutic Targets for Medulloblastomas |
| title_fullStr | MicroRNAs as Biomarkers and Therapeutic Targets for Medulloblastomas |
| title_full_unstemmed | MicroRNAs as Biomarkers and Therapeutic Targets for Medulloblastomas |
| title_short | MicroRNAs as Biomarkers and Therapeutic Targets for Medulloblastomas |
| title_sort | micrornas as biomarkers and therapeutic targets for medulloblastomas |
| topic | medulloblastoma microrna central nervous system neoplasms genetic heterogeneity biomarkers carcinogenesis suppressor genes therapeutic targets |
| url | https://www.surgonco.ru/jour/article/view/535 |
| work_keys_str_mv | AT oabeylerli micrornasasbiomarkersandtherapeutictargetsformedulloblastomas AT ifgareev micrornasasbiomarkersandtherapeutictargetsformedulloblastomas AT abalyshov micrornasasbiomarkersandtherapeutictargetsformedulloblastomas AT vvkudriashov micrornasasbiomarkersandtherapeutictargetsformedulloblastomas |