Non-synonymous ERG11 mutations in M. restricta and M. arunalokei: impact on azole susceptibility

Non-synonymous ERG11 mutations in M. restricta and M. arunalokei: impact on azole susceptibility

ABSTRACT Malassezia are commensal lipid-dependent yeasts and opportunistic pathogens that cause superficial mycoses and systemic infection. Azole antifungals target cell wall ergosterol synthesis and are the first line of antifungal treatment. ERG11 gene mutations and overexpression are major mechan...

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Bibliographic Details
Main Authors: Cheryl Leong, Wisely Chua, Cheng-Shoong Chong, Shi Mun Lee, Sebastian Maurer-Stroh, Won Hee Jung, Thomas L. Dawson
Format: Article
Language:English
Published: American Society for Microbiology 2025-06-01
Series:Microbiology Spectrum
Subjects:
antifungal
resistance
azoles
Malassezia
ERG11
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00007-25
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