Synthesis, Isolation and Characterization of Process-Related Impurities in Salbutamol Sulphate

Three known and one unknown impurities in salbutamol sulphate bulk drug at level 0.1% (ranging from 0.05-0.1%) were detected by gradient reverse phase high performance liquid chromatography. These impurities were preliminarily identified by the mass number of the impurities. Different experiments we...

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Bibliographic Details
Main Authors: Yogesh Kumar Sharma, Dau Dayal Agarwal, Sudesh Bhure, Rajendra Nath Mukharjee, Pramod Kumar Sahu, Santosh Bhardwaj
Format: Article
Language:English
Published: Wiley 2011-01-01
Series:E-Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2011/230231
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Summary:Three known and one unknown impurities in salbutamol sulphate bulk drug at level 0.1% (ranging from 0.05-0.1%) were detected by gradient reverse phase high performance liquid chromatography. These impurities were preliminarily identified by the mass number of the impurities. Different experiments were conducted and finally synthesized and characterized the known and unknown imputities.
ISSN:0973-4945
2090-9810