Use of PULSAR (personalized ultra-fractionated stereotactic adaptive radiotherapy) as consolidation with immune checkpoint inhibition in the treatment of pediatric metastatic melanoma

Use of PULSAR (personalized ultra-fractionated stereotactic adaptive radiotherapy) as consolidation with immune checkpoint inhibition in the treatment of pediatric metastatic melanoma

Abstract We present a case of extensive and bulky pediatric metastatic melanoma originating in the head and neck which markedly responded to combination therapy with anti-programmed cell death (PD-1) inhibition and consolidative personalized ultra-fractionated stereotactic adaptive radiotherapy (PUL...

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Bibliographic Details
Main Authors: Kyra L. McCarty, Tanya Watt, Tu D. Dan, Robert D. Timmerman, Kiran A. Kumar
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Radiation Oncology
Subjects:
Metastatic melanoma
PULSAR
Pembrolizumab
anti-PD-1
anti-CTLA-4
BRAF Inhibition
Online Access:https://doi.org/10.1186/s13014-025-02691-y
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