A single centre experience of patients with rare cancers referred for early phase clinical trials

Abstract Background Cancers affecting < 6/100,000/year are classified as rare, but they account for up to 25% of all cancers and are associated with worse 5-year survival than common cancers. Early-phase clinical trials (EPCTs) may represent a viable treatment option for patients with rare cancer...

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Main Authors: Angelos Angelakas, Natalie Cook, Donna M. Graham, Matthew Krebs, Fiona Thistlethwaite, Louise Carter
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Cancer
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Online Access:https://doi.org/10.1186/s12885-025-13934-2
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author Angelos Angelakas
Natalie Cook
Donna M. Graham
Matthew Krebs
Fiona Thistlethwaite
Louise Carter
author_facet Angelos Angelakas
Natalie Cook
Donna M. Graham
Matthew Krebs
Fiona Thistlethwaite
Louise Carter
author_sort Angelos Angelakas
collection DOAJ
description Abstract Background Cancers affecting < 6/100,000/year are classified as rare, but they account for up to 25% of all cancers and are associated with worse 5-year survival than common cancers. Early-phase clinical trials (EPCTs) may represent a viable treatment option for patients with rare cancers as they have evolved significantly with novel designs and the increasing use of precision medicine. Methods A retrospective study of patients with rare cancers referred to a large EPCT team at a UK specialist centre over 5 years (2016–2020) was conducted. Patient demographics, medical and oncological history, genomic variants, EPCT participation, responses and survival outcomes were analysed. Results In total, 240 patients with rare cancers were included. The mean age at diagnosis was 51.7 years (range 16–84), 54.2% of the patients were female. The most frequent rare cancers originated from the digestive system (27.1%), female genital tract (20%) and head and neck (H + N) (18.3%). Molecular profiling was offered to 45.5% of the population, median number of gene alterations was 3 per patient (range 1–20) while actionable gene alterations were reported in 60.2% (n = 50) of those with identified gene aberrations. Fifty-one patients participated in EPCTs, with 39.2% achieving SD and 11.8% PR. Median PFS for trial participants was three months (95% CI 1.12 – 4.88) while median OS in the trial patients was 16 months (95% CI 9.10 – 22.90) compared to 7 months for non-trial participants (95% CI 5.50 – 8.51). Finally, poor Royal Marsden Hospital (RMH) prognostic score (2–3) was correlated with worse survival when controlling for age and sex (HR 1.714, 95% CI 1.19 – 2.46, p = 0.004). Conclusions Participation of patients with rare cancers in EPCTs may be associated with a survival benefit and lead to the development of new treatments for these patients. Moreover, expanded use of precision medicine is paramount as it can inform targeted treatment selection in this heterogenous group.
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spelling doaj-art-392d2aef09694085b7f209691e5ef5482025-08-20T02:49:30ZengBMCBMC Cancer1471-24072025-03-0125111210.1186/s12885-025-13934-2A single centre experience of patients with rare cancers referred for early phase clinical trialsAngelos Angelakas0Natalie Cook1Donna M. Graham2Matthew Krebs3Fiona Thistlethwaite4Louise Carter5Department of Medical Oncology, The Christie NHS Foundation TrustDivision of Cancer Sciences, Faculty of Biology, Medicine and Health, University of ManchesterDivision of Cancer Sciences, Faculty of Biology, Medicine and Health, University of ManchesterDivision of Cancer Sciences, Faculty of Biology, Medicine and Health, University of ManchesterDivision of Cancer Sciences, Faculty of Biology, Medicine and Health, University of ManchesterDivision of Cancer Sciences, Faculty of Biology, Medicine and Health, University of ManchesterAbstract Background Cancers affecting < 6/100,000/year are classified as rare, but they account for up to 25% of all cancers and are associated with worse 5-year survival than common cancers. Early-phase clinical trials (EPCTs) may represent a viable treatment option for patients with rare cancers as they have evolved significantly with novel designs and the increasing use of precision medicine. Methods A retrospective study of patients with rare cancers referred to a large EPCT team at a UK specialist centre over 5 years (2016–2020) was conducted. Patient demographics, medical and oncological history, genomic variants, EPCT participation, responses and survival outcomes were analysed. Results In total, 240 patients with rare cancers were included. The mean age at diagnosis was 51.7 years (range 16–84), 54.2% of the patients were female. The most frequent rare cancers originated from the digestive system (27.1%), female genital tract (20%) and head and neck (H + N) (18.3%). Molecular profiling was offered to 45.5% of the population, median number of gene alterations was 3 per patient (range 1–20) while actionable gene alterations were reported in 60.2% (n = 50) of those with identified gene aberrations. Fifty-one patients participated in EPCTs, with 39.2% achieving SD and 11.8% PR. Median PFS for trial participants was three months (95% CI 1.12 – 4.88) while median OS in the trial patients was 16 months (95% CI 9.10 – 22.90) compared to 7 months for non-trial participants (95% CI 5.50 – 8.51). Finally, poor Royal Marsden Hospital (RMH) prognostic score (2–3) was correlated with worse survival when controlling for age and sex (HR 1.714, 95% CI 1.19 – 2.46, p = 0.004). Conclusions Participation of patients with rare cancers in EPCTs may be associated with a survival benefit and lead to the development of new treatments for these patients. Moreover, expanded use of precision medicine is paramount as it can inform targeted treatment selection in this heterogenous group.https://doi.org/10.1186/s12885-025-13934-2Rare cancersEarly phase trialsReal world dataPrognosisPrecision medicineMolecular profiling
spellingShingle Angelos Angelakas
Natalie Cook
Donna M. Graham
Matthew Krebs
Fiona Thistlethwaite
Louise Carter
A single centre experience of patients with rare cancers referred for early phase clinical trials
BMC Cancer
Rare cancers
Early phase trials
Real world data
Prognosis
Precision medicine
Molecular profiling
title A single centre experience of patients with rare cancers referred for early phase clinical trials
title_full A single centre experience of patients with rare cancers referred for early phase clinical trials
title_fullStr A single centre experience of patients with rare cancers referred for early phase clinical trials
title_full_unstemmed A single centre experience of patients with rare cancers referred for early phase clinical trials
title_short A single centre experience of patients with rare cancers referred for early phase clinical trials
title_sort single centre experience of patients with rare cancers referred for early phase clinical trials
topic Rare cancers
Early phase trials
Real world data
Prognosis
Precision medicine
Molecular profiling
url https://doi.org/10.1186/s12885-025-13934-2
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