A case report of olmesartan‐associated sprue‐like enteropathy: Diagnosis and healing confirmed by capsule endoscopy
Abstract Herein, we describe a case of olmesartan‐related sprue‐like enteropathy in which improvement in villous atrophy was confirmed by small‐bowel capsule endoscopy (CE). We successfully treated a 66‐year‐old man with a chief complaint of loose diarrhea. The patient had persistent watery diarrhea...
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2023-04-01
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| Online Access: | https://doi.org/10.1002/deo2.142 |
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| author | Yoshiharu Yamaguchi Takahiro Miwa Ryo Murakami Akane Sugimura Kazuhiro Yamamoto Tomoya Sugiyama Yasuhiro Tamura Shinya Izawa Masahide Ebi Yasushi Funaki Naotaka Ogasawara Makoto Sasaki Kunio Kasugai |
| author_facet | Yoshiharu Yamaguchi Takahiro Miwa Ryo Murakami Akane Sugimura Kazuhiro Yamamoto Tomoya Sugiyama Yasuhiro Tamura Shinya Izawa Masahide Ebi Yasushi Funaki Naotaka Ogasawara Makoto Sasaki Kunio Kasugai |
| author_sort | Yoshiharu Yamaguchi |
| collection | DOAJ |
| description | Abstract Herein, we describe a case of olmesartan‐related sprue‐like enteropathy in which improvement in villous atrophy was confirmed by small‐bowel capsule endoscopy (CE). We successfully treated a 66‐year‐old man with a chief complaint of loose diarrhea. The patient had persistent watery diarrhea 10 times a day and experienced a weight loss of 9 kg in 3 months. An abdominal computed tomography scan showed fluid retention in the small intestine. Blood test results revealed no inflammatory reaction. Esophagogastroduodenoscopy detected villous atrophy in the stomach and duodenum. Moreover, small‐bowel CE showed villous atrophy in about two‐thirds of the small intestine. Based on other examinations, hyperthyroidism, intestinal tuberculosis, intestinal amyloidosis, and intestinal malignant lymphoma were ruled out. Therefore, the patient was suspected of having an olmesartan‐related sprue‐like disease. Early after discontinuation of medication, diarrhea symptoms improved, and a repeat CE indicated improvements in small intestinal villous atrophy. Since the patient had been administered olmesartan for a long time and CE showed villous atrophy throughout the small bowel, we suspected him of having the olmesartan‐associated sprue‐like disease. The findings of gastric mucosa atrophy on esophagogastroduodenoscopy may lead to an early diagnosis of this disease. Olmesartan‐related sprue‐like enteropathy should be considered as a differential diagnosis in patients with chronic severe watery diarrhea. |
| format | Article |
| id | doaj-art-392be23999104ff3abc01c7b4fcc6f32 |
| institution | DOAJ |
| issn | 2692-4609 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | DEN Open |
| spelling | doaj-art-392be23999104ff3abc01c7b4fcc6f322025-08-20T03:10:11ZengWileyDEN Open2692-46092023-04-0131n/an/a10.1002/deo2.142A case report of olmesartan‐associated sprue‐like enteropathy: Diagnosis and healing confirmed by capsule endoscopyYoshiharu Yamaguchi0Takahiro Miwa1Ryo Murakami2Akane Sugimura3Kazuhiro Yamamoto4Tomoya Sugiyama5Yasuhiro Tamura6Shinya Izawa7Masahide Ebi8Yasushi Funaki9Naotaka Ogasawara10Makoto Sasaki11Kunio Kasugai12Department of Gastroenterology Aichi Medical University School of Medicine Aichi JapanDepartment of Gastroenterology Aichi Medical University School of Medicine Aichi JapanDepartment of Gastroenterology Tajimi City Hospital Gifu JapanDepartment of Gastroenterology Aichi Medical University School of Medicine Aichi JapanDepartment of Gastroenterology Aichi Medical University School of Medicine Aichi JapanDepartment of Gastroenterology Aichi Medical University School of Medicine Aichi JapanDepartment of Gastroenterology Aichi Medical University School of Medicine Aichi JapanDepartment of Gastroenterology Aichi Medical University School of Medicine Aichi JapanDepartment of Gastroenterology Aichi Medical University School of Medicine Aichi JapanDepartment of Gastroenterology Aichi Medical University School of Medicine Aichi JapanDepartment of Gastroenterology Aichi Medical University School of Medicine Aichi JapanDepartment of Gastroenterology Aichi Medical University School of Medicine Aichi JapanDepartment of Gastroenterology Aichi Medical University School of Medicine Aichi JapanAbstract Herein, we describe a case of olmesartan‐related sprue‐like enteropathy in which improvement in villous atrophy was confirmed by small‐bowel capsule endoscopy (CE). We successfully treated a 66‐year‐old man with a chief complaint of loose diarrhea. The patient had persistent watery diarrhea 10 times a day and experienced a weight loss of 9 kg in 3 months. An abdominal computed tomography scan showed fluid retention in the small intestine. Blood test results revealed no inflammatory reaction. Esophagogastroduodenoscopy detected villous atrophy in the stomach and duodenum. Moreover, small‐bowel CE showed villous atrophy in about two‐thirds of the small intestine. Based on other examinations, hyperthyroidism, intestinal tuberculosis, intestinal amyloidosis, and intestinal malignant lymphoma were ruled out. Therefore, the patient was suspected of having an olmesartan‐related sprue‐like disease. Early after discontinuation of medication, diarrhea symptoms improved, and a repeat CE indicated improvements in small intestinal villous atrophy. Since the patient had been administered olmesartan for a long time and CE showed villous atrophy throughout the small bowel, we suspected him of having the olmesartan‐associated sprue‐like disease. The findings of gastric mucosa atrophy on esophagogastroduodenoscopy may lead to an early diagnosis of this disease. Olmesartan‐related sprue‐like enteropathy should be considered as a differential diagnosis in patients with chronic severe watery diarrhea.https://doi.org/10.1002/deo2.142atrophycapsule endoscopydiarrheahypertensionolmesartan |
| spellingShingle | Yoshiharu Yamaguchi Takahiro Miwa Ryo Murakami Akane Sugimura Kazuhiro Yamamoto Tomoya Sugiyama Yasuhiro Tamura Shinya Izawa Masahide Ebi Yasushi Funaki Naotaka Ogasawara Makoto Sasaki Kunio Kasugai A case report of olmesartan‐associated sprue‐like enteropathy: Diagnosis and healing confirmed by capsule endoscopy DEN Open atrophy capsule endoscopy diarrhea hypertension olmesartan |
| title | A case report of olmesartan‐associated sprue‐like enteropathy: Diagnosis and healing confirmed by capsule endoscopy |
| title_full | A case report of olmesartan‐associated sprue‐like enteropathy: Diagnosis and healing confirmed by capsule endoscopy |
| title_fullStr | A case report of olmesartan‐associated sprue‐like enteropathy: Diagnosis and healing confirmed by capsule endoscopy |
| title_full_unstemmed | A case report of olmesartan‐associated sprue‐like enteropathy: Diagnosis and healing confirmed by capsule endoscopy |
| title_short | A case report of olmesartan‐associated sprue‐like enteropathy: Diagnosis and healing confirmed by capsule endoscopy |
| title_sort | case report of olmesartan associated sprue like enteropathy diagnosis and healing confirmed by capsule endoscopy |
| topic | atrophy capsule endoscopy diarrhea hypertension olmesartan |
| url | https://doi.org/10.1002/deo2.142 |
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