Intestinal microbiom as a therapeutic target in treatment of chronic non-alcoholic fat liver disease
While standard diets, changes in the way of life, and pathogenically oriented methods of treatment of non-alcoholic fat liver disease are often ineffective, it is necessary to develop new approaches aimed to other targets. Under the conditions of damaged intestinal barrier (“leaking bowel”), and bow...
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| Format: | Article |
| Language: | Russian |
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Open Systems Publication
2021-06-01
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| Series: | Лечащий Врач |
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| Online Access: | https://journal.lvrach.ru/jour/article/view/562 |
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| _version_ | 1849694842215464960 |
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| author | E. Yu. Plotnikova Yu. V. Zakharova T. Yu. Gracheva |
| author_facet | E. Yu. Plotnikova Yu. V. Zakharova T. Yu. Gracheva |
| author_sort | E. Yu. Plotnikova |
| collection | DOAJ |
| description | While standard diets, changes in the way of life, and pathogenically oriented methods of treatment of non-alcoholic fat liver disease are often ineffective, it is necessary to develop new approaches aimed to other targets. Under the conditions of damaged intestinal barrier (“leaking bowel”), and bowel- liver axis, it is possible to improve natural interaction between the intestinal bacteria and peptic receptors, which contributes to the following course of events: oxidative stress, insulin-resistance, liver inflammation and fibrosis. The article also highlights possibility of intestinal microbiota modulation with probiotics. |
| format | Article |
| id | doaj-art-392b7eddce8e4020afcb2b5656cbc70d |
| institution | DOAJ |
| issn | 1560-5175 2687-1181 |
| language | Russian |
| publishDate | 2021-06-01 |
| publisher | Open Systems Publication |
| record_format | Article |
| series | Лечащий Врач |
| spelling | doaj-art-392b7eddce8e4020afcb2b5656cbc70d2025-08-20T03:19:57ZrusOpen Systems PublicationЛечащий Врач1560-51752687-11812021-06-0108561Intestinal microbiom as a therapeutic target in treatment of chronic non-alcoholic fat liver diseaseE. Yu. Plotnikova0Yu. V. Zakharova1T. Yu. Gracheva2ФГБОУ ВО КемГМУ МЗ РФФГБОУ ВО КемГМУ МЗ РФФГБОУ ВО КемГМУ МЗ РФWhile standard diets, changes in the way of life, and pathogenically oriented methods of treatment of non-alcoholic fat liver disease are often ineffective, it is necessary to develop new approaches aimed to other targets. Under the conditions of damaged intestinal barrier (“leaking bowel”), and bowel- liver axis, it is possible to improve natural interaction between the intestinal bacteria and peptic receptors, which contributes to the following course of events: oxidative stress, insulin-resistance, liver inflammation and fibrosis. The article also highlights possibility of intestinal microbiota modulation with probiotics.https://journal.lvrach.ru/jour/article/view/562probioticsintestinal microbiotasyndrome of excessive bacterial growthnon-alcoholic fat liver disease |
| spellingShingle | E. Yu. Plotnikova Yu. V. Zakharova T. Yu. Gracheva Intestinal microbiom as a therapeutic target in treatment of chronic non-alcoholic fat liver disease Лечащий Врач probiotics intestinal microbiota syndrome of excessive bacterial growth non-alcoholic fat liver disease |
| title | Intestinal microbiom as a therapeutic target in treatment of chronic non-alcoholic fat liver disease |
| title_full | Intestinal microbiom as a therapeutic target in treatment of chronic non-alcoholic fat liver disease |
| title_fullStr | Intestinal microbiom as a therapeutic target in treatment of chronic non-alcoholic fat liver disease |
| title_full_unstemmed | Intestinal microbiom as a therapeutic target in treatment of chronic non-alcoholic fat liver disease |
| title_short | Intestinal microbiom as a therapeutic target in treatment of chronic non-alcoholic fat liver disease |
| title_sort | intestinal microbiom as a therapeutic target in treatment of chronic non alcoholic fat liver disease |
| topic | probiotics intestinal microbiota syndrome of excessive bacterial growth non-alcoholic fat liver disease |
| url | https://journal.lvrach.ru/jour/article/view/562 |
| work_keys_str_mv | AT eyuplotnikova intestinalmicrobiomasatherapeutictargetintreatmentofchronicnonalcoholicfatliverdisease AT yuvzakharova intestinalmicrobiomasatherapeutictargetintreatmentofchronicnonalcoholicfatliverdisease AT tyugracheva intestinalmicrobiomasatherapeutictargetintreatmentofchronicnonalcoholicfatliverdisease |