CXCR4 promotes gefitinib resistance of Huh7 cells by activating the c‐Met signaling pathway

CXCR4 promotes gefitinib resistance of Huh7 cells by activating the c‐Met signaling pathway

C‐X‐C chemokine receptor type 4 (CXCR4) expression is associated with poor prognosis of hepatocellular carcinoma (HCC). The aim of this study was to explore the biological role of CXCR4 in gefitinib resistance of HCC. Compared with a normal, non‐gefitinib‐resistant, human HCC cell line (Huh7), CXCR4...

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Bibliographic Details
Main Authors: Dali Zhao, Zhiqiang Yang, Chen Chen, Zhipeng Zhang, Yangsheng Yu, Zhituo Li
Format: Article
Language:English
Published: Wiley 2021-11-01
Series:FEBS Open Bio
Subjects:
Cav‐1
c‐Met
CXCR4
gefitinib resistance
hepatocellular carcinoma
Online Access:https://doi.org/10.1002/2211-5463.13305
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