Genetic diversity and comparative genomics across Leishmania (Viannia) species
Abstract Leishmaniasis is an important public health problem worldwide, with a broad spectrum of clinical and epidemiological features partly associated with the diversity and complex life cycle of the Leishmania parasites. This study analyzes genomic data from 205 Leishmania (Viannia) samples, incl...
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| Language: | English |
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Nature Portfolio
2025-06-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-08331-1 |
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| author | Laura Natalia Gonzalez-Garcia Maria Paula Rodriguez Marcela Parra-Muñoz Ana M. Clavijo Laura Levy Clemencia Ovalle-Bracho Claudia Colorado Carolina Camargo Eyson Quiceno Maria Juliana Moncada Carlos Muskus Daniel Alfonso Urrea Felipe Baez-Aguirre Silvia Restrepo María Clara Echeverry Jorge Duitama |
| author_facet | Laura Natalia Gonzalez-Garcia Maria Paula Rodriguez Marcela Parra-Muñoz Ana M. Clavijo Laura Levy Clemencia Ovalle-Bracho Claudia Colorado Carolina Camargo Eyson Quiceno Maria Juliana Moncada Carlos Muskus Daniel Alfonso Urrea Felipe Baez-Aguirre Silvia Restrepo María Clara Echeverry Jorge Duitama |
| author_sort | Laura Natalia Gonzalez-Garcia |
| collection | DOAJ |
| description | Abstract Leishmaniasis is an important public health problem worldwide, with a broad spectrum of clinical and epidemiological features partly associated with the diversity and complex life cycle of the Leishmania parasites. This study analyzes genomic data from 205 Leishmania (Viannia) samples, including 65 newly sequenced clinical isolates. It also provides chromosome-level genome assemblies for 10 isolates representing different species and populations. The observed distribution of Leishmania genomic diversity across the sampling locations suggests rapid adaptation to different ecosystems. The phylogenomic analysis provides new hypotheses challenging the current delimitation of species. Pangenomic analysis of high-quality assemblies shows consistent copy number variation between species for different gene families. Larger and more diverse amastin gene families were observed in the assembled genomes compared to previous reports based on the analysis of short-read data. This work provides genomic resources and helpful information regarding central problems in the biology of Leishmania spp, including species diversification, transmission dynamics, and the evolution of virulence mechanisms. |
| format | Article |
| id | doaj-art-392248109ac2486fb9b8fb4f7dc7c982 |
| institution | OA Journals |
| issn | 2399-3642 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-392248109ac2486fb9b8fb4f7dc7c9822025-08-20T02:07:45ZengNature PortfolioCommunications Biology2399-36422025-06-018111410.1038/s42003-025-08331-1Genetic diversity and comparative genomics across Leishmania (Viannia) speciesLaura Natalia Gonzalez-Garcia0Maria Paula Rodriguez1Marcela Parra-Muñoz2Ana M. Clavijo3Laura Levy4Clemencia Ovalle-Bracho5Claudia Colorado6Carolina Camargo7Eyson Quiceno8Maria Juliana Moncada9Carlos Muskus10Daniel Alfonso Urrea11Felipe Baez-Aguirre12Silvia Restrepo13María Clara Echeverry14Jorge Duitama15Systems and Computing Engineering Department, Universidad de los AndesSystems and Computing Engineering Department, Universidad de los AndesDepartamento de Salud Pública, Facultad de Medicina, Universidad Nacional de Colombia – Sede BogotáDepartamento de Salud Pública, Facultad de Medicina, Universidad Nacional de Colombia – Sede BogotáSystems and Computing Engineering Department, Universidad de los AndesHospital Universitario Centro Dermatológico Federico Lleras Acosta E.S.EHospital Universitario Centro Dermatológico Federico Lleras Acosta E.S.EHospital Universitario Centro Dermatológico Federico Lleras Acosta E.S.EPrograma de Estudio y Control de Enfermedades Tropicales-PECET, Facultad de Medicina, Universidad de AntioquiaPrograma de Estudio y Control de Enfermedades Tropicales-PECET, Facultad de Medicina, Universidad de AntioquiaPrograma de Estudio y Control de Enfermedades Tropicales-PECET, Facultad de Medicina, Universidad de AntioquiaLaboratorio de Investigaciones en Parasitología Tropical (LIPT), Universidad del TolimaApplied Genomics Research Group, Vicerrectoría de Investigación y Creación, Universidad de los AndesUniversidad de los AndesDepartamento de Salud Pública, Facultad de Medicina, Universidad Nacional de Colombia – Sede BogotáSystems and Computing Engineering Department, Universidad de los AndesAbstract Leishmaniasis is an important public health problem worldwide, with a broad spectrum of clinical and epidemiological features partly associated with the diversity and complex life cycle of the Leishmania parasites. This study analyzes genomic data from 205 Leishmania (Viannia) samples, including 65 newly sequenced clinical isolates. It also provides chromosome-level genome assemblies for 10 isolates representing different species and populations. The observed distribution of Leishmania genomic diversity across the sampling locations suggests rapid adaptation to different ecosystems. The phylogenomic analysis provides new hypotheses challenging the current delimitation of species. Pangenomic analysis of high-quality assemblies shows consistent copy number variation between species for different gene families. Larger and more diverse amastin gene families were observed in the assembled genomes compared to previous reports based on the analysis of short-read data. This work provides genomic resources and helpful information regarding central problems in the biology of Leishmania spp, including species diversification, transmission dynamics, and the evolution of virulence mechanisms.https://doi.org/10.1038/s42003-025-08331-1 |
| spellingShingle | Laura Natalia Gonzalez-Garcia Maria Paula Rodriguez Marcela Parra-Muñoz Ana M. Clavijo Laura Levy Clemencia Ovalle-Bracho Claudia Colorado Carolina Camargo Eyson Quiceno Maria Juliana Moncada Carlos Muskus Daniel Alfonso Urrea Felipe Baez-Aguirre Silvia Restrepo María Clara Echeverry Jorge Duitama Genetic diversity and comparative genomics across Leishmania (Viannia) species Communications Biology |
| title | Genetic diversity and comparative genomics across Leishmania (Viannia) species |
| title_full | Genetic diversity and comparative genomics across Leishmania (Viannia) species |
| title_fullStr | Genetic diversity and comparative genomics across Leishmania (Viannia) species |
| title_full_unstemmed | Genetic diversity and comparative genomics across Leishmania (Viannia) species |
| title_short | Genetic diversity and comparative genomics across Leishmania (Viannia) species |
| title_sort | genetic diversity and comparative genomics across leishmania viannia species |
| url | https://doi.org/10.1038/s42003-025-08331-1 |
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