Prognostic Value of Immune Scoring System for Colorectal Cancer Patients with Peritoneal Metastasis
<i>Background and Objectives:</i> There is no reliable immune scoring system that can help us predict the postoperative outcomes of colorectal cancer patients with peritoneal metastases after cytoreductive surgery. In this cohort, the aims were (1) to evaluate the postoperative morbidity...
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MDPI AG
2024-12-01
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| author | Berke Manoğlu Selman Sökmen Tufan Egeli Zekai Serhan Derici Cihan Ağalar Süleyman Özkan Aksoy |
| author_facet | Berke Manoğlu Selman Sökmen Tufan Egeli Zekai Serhan Derici Cihan Ağalar Süleyman Özkan Aksoy |
| author_sort | Berke Manoğlu |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> There is no reliable immune scoring system that can help us predict the postoperative outcomes of colorectal cancer patients with peritoneal metastases after cytoreductive surgery. In this cohort, the aims were (1) to evaluate the postoperative morbidity, mortality and surgical oncological outcomes in colorectal cancer patients with peritoneal metastasis; (2) to compare oncological and postoperative outcomes of colon cancer patients with peritoneal metastasis and rectal cancer patients with peritoneal metastasis; and (3) to assess the prognostic value of the modified Glasgow Prognostic Score (mGPS) and the CRP–albumin ratio (CAR). <i>Materials and Methods</i>: A prospectively maintained database of 258 patients who underwent cytoreductive surgery for peritoneal metastases of colorectal origin between 2007 and 2024 was analyzed. According to the anatomical location of the primary tumor, two different groups were created: rectum cancer patients with peritoneal metastasis (Group A) and colon cancer patients with peritoneal metastasis (Group B). All standard clinico-pathological characteristics, operative findings, morbi-mortality results, and final oncologic outcomes were compared between Groups A and B. We evaluated whether CAR and mGPS could predict postoperative morbi-mortality and overall survival in the two groups or not. <i>Results</i>: No significant difference was detected between Groups A and B in terms of clinical–demographic characteristics. In both groups, the preoperative mGPS and CAR values were statistically significantly higher in those who developed postoperative high-grade complications (C-D grade III/IV) (<i>p</i> < 0.001) and those who died perioperatively (<i>p</i> = 0.001 and <i>p</i> = 0.002). <i>Conclusions</i>: In multivariate Cox analysis, the CAR was found to be an independent prognostic factor for overall survival in this cohort. CAR and mGPS predicted high-grade complications and postoperative mortality in both groups. |
| format | Article |
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| institution | OA Journals |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Medicina |
| spelling | doaj-art-391a8df484634d43b75e811bc8a130c82025-08-20T02:00:39ZengMDPI AGMedicina1010-660X1648-91442024-12-016012207010.3390/medicina60122070Prognostic Value of Immune Scoring System for Colorectal Cancer Patients with Peritoneal MetastasisBerke Manoğlu0Selman Sökmen1Tufan Egeli2Zekai Serhan Derici3Cihan Ağalar4Süleyman Özkan Aksoy5Peritoneal Surface Malignancy Center, Department of Surgery, Dokuz Eylul University Faculty of Medicine, 35340 Balcova, TurkeyPeritoneal Surface Malignancy Center, Department of Surgery, Dokuz Eylul University Faculty of Medicine, 35340 Balcova, TurkeyPeritoneal Surface Malignancy Center, Department of Surgery, Dokuz Eylul University Faculty of Medicine, 35340 Balcova, TurkeyPeritoneal Surface Malignancy Center, Department of Surgery, Dokuz Eylul University Faculty of Medicine, 35340 Balcova, TurkeyPeritoneal Surface Malignancy Center, Department of Surgery, Dokuz Eylul University Faculty of Medicine, 35340 Balcova, TurkeyPeritoneal Surface Malignancy Center, Department of Surgery, Dokuz Eylul University Faculty of Medicine, 35340 Balcova, Turkey<i>Background and Objectives:</i> There is no reliable immune scoring system that can help us predict the postoperative outcomes of colorectal cancer patients with peritoneal metastases after cytoreductive surgery. In this cohort, the aims were (1) to evaluate the postoperative morbidity, mortality and surgical oncological outcomes in colorectal cancer patients with peritoneal metastasis; (2) to compare oncological and postoperative outcomes of colon cancer patients with peritoneal metastasis and rectal cancer patients with peritoneal metastasis; and (3) to assess the prognostic value of the modified Glasgow Prognostic Score (mGPS) and the CRP–albumin ratio (CAR). <i>Materials and Methods</i>: A prospectively maintained database of 258 patients who underwent cytoreductive surgery for peritoneal metastases of colorectal origin between 2007 and 2024 was analyzed. According to the anatomical location of the primary tumor, two different groups were created: rectum cancer patients with peritoneal metastasis (Group A) and colon cancer patients with peritoneal metastasis (Group B). All standard clinico-pathological characteristics, operative findings, morbi-mortality results, and final oncologic outcomes were compared between Groups A and B. We evaluated whether CAR and mGPS could predict postoperative morbi-mortality and overall survival in the two groups or not. <i>Results</i>: No significant difference was detected between Groups A and B in terms of clinical–demographic characteristics. In both groups, the preoperative mGPS and CAR values were statistically significantly higher in those who developed postoperative high-grade complications (C-D grade III/IV) (<i>p</i> < 0.001) and those who died perioperatively (<i>p</i> = 0.001 and <i>p</i> = 0.002). <i>Conclusions</i>: In multivariate Cox analysis, the CAR was found to be an independent prognostic factor for overall survival in this cohort. CAR and mGPS predicted high-grade complications and postoperative mortality in both groups.https://www.mdpi.com/1648-9144/60/12/2070colorectal cancerimmunoscoreperitoneal metastasesmGPSCAR |
| spellingShingle | Berke Manoğlu Selman Sökmen Tufan Egeli Zekai Serhan Derici Cihan Ağalar Süleyman Özkan Aksoy Prognostic Value of Immune Scoring System for Colorectal Cancer Patients with Peritoneal Metastasis Medicina colorectal cancer immunoscore peritoneal metastases mGPS CAR |
| title | Prognostic Value of Immune Scoring System for Colorectal Cancer Patients with Peritoneal Metastasis |
| title_full | Prognostic Value of Immune Scoring System for Colorectal Cancer Patients with Peritoneal Metastasis |
| title_fullStr | Prognostic Value of Immune Scoring System for Colorectal Cancer Patients with Peritoneal Metastasis |
| title_full_unstemmed | Prognostic Value of Immune Scoring System for Colorectal Cancer Patients with Peritoneal Metastasis |
| title_short | Prognostic Value of Immune Scoring System for Colorectal Cancer Patients with Peritoneal Metastasis |
| title_sort | prognostic value of immune scoring system for colorectal cancer patients with peritoneal metastasis |
| topic | colorectal cancer immunoscore peritoneal metastases mGPS CAR |
| url | https://www.mdpi.com/1648-9144/60/12/2070 |
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