Prognostic implications of complement C1q-like 4 expression in breast cancer
Abstract Higher expression of Complement C1q-like protein 4 (C1ql4) in breast cancer may be associated with increased tumor malignancy. As a protein involved in immune responses and inflammation, C1ql4 is expressed across all molecular subtypes of breast cancer. We conducted a retrospective analysis...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-12557-8 |
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| author | Qing Zhang Zhijun Xing Lu Bai Xiao Li Fan Xu |
| author_facet | Qing Zhang Zhijun Xing Lu Bai Xiao Li Fan Xu |
| author_sort | Qing Zhang |
| collection | DOAJ |
| description | Abstract Higher expression of Complement C1q-like protein 4 (C1ql4) in breast cancer may be associated with increased tumor malignancy. As a protein involved in immune responses and inflammation, C1ql4 is expressed across all molecular subtypes of breast cancer. We conducted a retrospective analysis and follow-up study involving 111 patients who underwent breast cancer resection at the Department of Breast Surgery, Affiliated Hospital of Chengde Medical College, to investigate the relationship between C1ql4 expression and overall survival, as well as to evaluate the prognostic value of C1ql4 both independently and in combination with conventional clinicopathologic parameters. Chi-square analysis revealed a significant positive difference between C1ql4 protein expression and TNM staging, as well as molecular subtypes. Moreover, patients with high C1ql4 expression demonstrated significantly poorer prognoses. In conclusion, our findings suggest that C1ql4 expression may serve as a potential biomarker for elevated breast cancer malignancy. |
| format | Article |
| id | doaj-art-391a77a420164ff998f1603fd7475b9f |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-391a77a420164ff998f1603fd7475b9f2025-08-20T04:03:00ZengNature PortfolioScientific Reports2045-23222025-07-011511910.1038/s41598-025-12557-8Prognostic implications of complement C1q-like 4 expression in breast cancerQing Zhang0Zhijun Xing1Lu Bai2Xiao Li3Fan Xu4Departments of Oncology, Affiliated Hospital of Chengde Medical UniversityDivision of General Thoracic Surgery, Department of Surgery, Shinshu University School of MedicineDepartments of Oncology, Affiliated Hospital of Chengde Medical UniversityDepartments of Oncology, Affiliated Hospital of Chengde Medical UniversityDepartments of Oncology, Affiliated Hospital of Chengde Medical UniversityAbstract Higher expression of Complement C1q-like protein 4 (C1ql4) in breast cancer may be associated with increased tumor malignancy. As a protein involved in immune responses and inflammation, C1ql4 is expressed across all molecular subtypes of breast cancer. We conducted a retrospective analysis and follow-up study involving 111 patients who underwent breast cancer resection at the Department of Breast Surgery, Affiliated Hospital of Chengde Medical College, to investigate the relationship between C1ql4 expression and overall survival, as well as to evaluate the prognostic value of C1ql4 both independently and in combination with conventional clinicopathologic parameters. Chi-square analysis revealed a significant positive difference between C1ql4 protein expression and TNM staging, as well as molecular subtypes. Moreover, patients with high C1ql4 expression demonstrated significantly poorer prognoses. In conclusion, our findings suggest that C1ql4 expression may serve as a potential biomarker for elevated breast cancer malignancy.https://doi.org/10.1038/s41598-025-12557-8 |
| spellingShingle | Qing Zhang Zhijun Xing Lu Bai Xiao Li Fan Xu Prognostic implications of complement C1q-like 4 expression in breast cancer Scientific Reports |
| title | Prognostic implications of complement C1q-like 4 expression in breast cancer |
| title_full | Prognostic implications of complement C1q-like 4 expression in breast cancer |
| title_fullStr | Prognostic implications of complement C1q-like 4 expression in breast cancer |
| title_full_unstemmed | Prognostic implications of complement C1q-like 4 expression in breast cancer |
| title_short | Prognostic implications of complement C1q-like 4 expression in breast cancer |
| title_sort | prognostic implications of complement c1q like 4 expression in breast cancer |
| url | https://doi.org/10.1038/s41598-025-12557-8 |
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