Rosai–Dorfman disease presenting as a scleral nodule in a female with multisystem inflammatory syndrome post-COVID-19 infection
We report a rare presentation of Rosai–Dorfman disease (RDD) as scleritis transforming to a nodule in a female with multisystem inflammatory syndrome following COVID-19 infection. A 54-year-old female presented to us first in August 2022 with redness and slight discomfort in both eyes of 2 weeks’ du...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Taiwan Journal of Ophthalmology |
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| Online Access: | https://journals.lww.com/10.4103/tjo.TJO-D-25-00009 |
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| author | Nashra Alma Smitha Kuthyar Shambu Kalpana Babu |
| author_facet | Nashra Alma Smitha Kuthyar Shambu Kalpana Babu |
| author_sort | Nashra Alma |
| collection | DOAJ |
| description | We report a rare presentation of Rosai–Dorfman disease (RDD) as scleritis transforming to a nodule in a female with multisystem inflammatory syndrome following COVID-19 infection. A 54-year-old female presented to us first in August 2022 with redness and slight discomfort in both eyes of 2 weeks’ duration. She had a history of multisystem inflammatory syndrome post-COVID-19 infection. Although she presented with scleritis (oculus uterque), it continued to persist with a course of oral and topical steroids. Laboratory investigations including autoimmune profile were negative. Only QuantiFERON-TB Gold test was positive. High-resolution computed tomography showed a few subcentimeter enlarged mediastinal lymph nodes and a cluster of enlarged cervical lymph nodes. Biopsy showed chronic granulomatous inflammation with no caseation, negative for Mycobacterium tuberculosis. Over a year, this transformed to a scleral nodule. Excision biopsy confirmed RDD disease. Whole body positron emission tomography-computerized tomography confirmed no active lesions elsewhere. She was started on methotrexate. At 1-year follow-up, there was no recurrence. |
| format | Article |
| id | doaj-art-391576b30cf3422bbe801e54f8a78c6e |
| institution | Kabale University |
| issn | 2211-5056 2211-5072 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Taiwan Journal of Ophthalmology |
| spelling | doaj-art-391576b30cf3422bbe801e54f8a78c6e2025-08-20T03:29:35ZengWolters Kluwer Medknow PublicationsTaiwan Journal of Ophthalmology2211-50562211-50722025-04-0115231932210.4103/tjo.TJO-D-25-00009Rosai–Dorfman disease presenting as a scleral nodule in a female with multisystem inflammatory syndrome post-COVID-19 infectionNashra AlmaSmitha Kuthyar ShambuKalpana BabuWe report a rare presentation of Rosai–Dorfman disease (RDD) as scleritis transforming to a nodule in a female with multisystem inflammatory syndrome following COVID-19 infection. A 54-year-old female presented to us first in August 2022 with redness and slight discomfort in both eyes of 2 weeks’ duration. She had a history of multisystem inflammatory syndrome post-COVID-19 infection. Although she presented with scleritis (oculus uterque), it continued to persist with a course of oral and topical steroids. Laboratory investigations including autoimmune profile were negative. Only QuantiFERON-TB Gold test was positive. High-resolution computed tomography showed a few subcentimeter enlarged mediastinal lymph nodes and a cluster of enlarged cervical lymph nodes. Biopsy showed chronic granulomatous inflammation with no caseation, negative for Mycobacterium tuberculosis. Over a year, this transformed to a scleral nodule. Excision biopsy confirmed RDD disease. Whole body positron emission tomography-computerized tomography confirmed no active lesions elsewhere. She was started on methotrexate. At 1-year follow-up, there was no recurrence.https://journals.lww.com/10.4103/tjo.TJO-D-25-00009biopsycovid-19 exposureimmunosuppressionmultisystem inflammatory syndromerosai–dorfman diseasescleral nodulescleritis |
| spellingShingle | Nashra Alma Smitha Kuthyar Shambu Kalpana Babu Rosai–Dorfman disease presenting as a scleral nodule in a female with multisystem inflammatory syndrome post-COVID-19 infection Taiwan Journal of Ophthalmology biopsy covid-19 exposure immunosuppression multisystem inflammatory syndrome rosai–dorfman disease scleral nodule scleritis |
| title | Rosai–Dorfman disease presenting as a scleral nodule in a female with multisystem inflammatory syndrome post-COVID-19 infection |
| title_full | Rosai–Dorfman disease presenting as a scleral nodule in a female with multisystem inflammatory syndrome post-COVID-19 infection |
| title_fullStr | Rosai–Dorfman disease presenting as a scleral nodule in a female with multisystem inflammatory syndrome post-COVID-19 infection |
| title_full_unstemmed | Rosai–Dorfman disease presenting as a scleral nodule in a female with multisystem inflammatory syndrome post-COVID-19 infection |
| title_short | Rosai–Dorfman disease presenting as a scleral nodule in a female with multisystem inflammatory syndrome post-COVID-19 infection |
| title_sort | rosai dorfman disease presenting as a scleral nodule in a female with multisystem inflammatory syndrome post covid 19 infection |
| topic | biopsy covid-19 exposure immunosuppression multisystem inflammatory syndrome rosai–dorfman disease scleral nodule scleritis |
| url | https://journals.lww.com/10.4103/tjo.TJO-D-25-00009 |
| work_keys_str_mv | AT nashraalma rosaidorfmandiseasepresentingasascleralnoduleinafemalewithmultisysteminflammatorysyndromepostcovid19infection AT smithakuthyarshambu rosaidorfmandiseasepresentingasascleralnoduleinafemalewithmultisysteminflammatorysyndromepostcovid19infection AT kalpanababu rosaidorfmandiseasepresentingasascleralnoduleinafemalewithmultisysteminflammatorysyndromepostcovid19infection |