Nicotinamide mononucleotide promotes female germline stem cell proliferation by activating the H4K16ac-Hmgb1-Fyn-PLD signaling pathway through epigenetic remodeling

Nicotinamide mononucleotide promotes female germline stem cell proliferation by activating the H4K16ac-Hmgb1-Fyn-PLD signaling pathway through epigenetic remodeling

Abstract Background Nicotinamide mononucleotide (NMN), an endogenous nucleotide essential for various physiological processes, has an unclear role and regulatory mechanisms in female germline stem cell (FGSC) development. Results We demonstrate that NMN significantly enhances FGSC viability and prol...

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Bibliographic Details
Main Authors: Hong Zhou, Yujie Liu, Geng G. Tian, Ji Wu
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Cell & Bioscience
Subjects:
NMN
FGSCs
H4K16ac
Hmgb1
Fyn
PLD signaling pathway
Online Access:https://doi.org/10.1186/s13578-025-01387-w
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