Research progress on the interactions between Treponema pallidum adhesion proteins and host cells
Treponema pallidum (Tp) has an outer membrane that encircles the periplasmic space, the peptidoglycan, cytoplasmic membrane, and protoplasmic components. The low abundance of lipopolysaccharides and transmembrane proteins enable it to conceal itself and to exert robust capabilities for tissue invasi...
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| Format: | Article |
| Language: | zho |
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editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology
2025-03-01
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| Series: | Pifu-xingbing zhenliaoxue zazhi |
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| Online Access: | http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2025.03.010 |
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| _version_ | 1849700790759849984 |
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| author | HUANG Jialin ZHENG Judun |
| author_facet | HUANG Jialin ZHENG Judun |
| author_sort | HUANG Jialin |
| collection | DOAJ |
| description | Treponema pallidum (Tp) has an outer membrane that encircles the periplasmic space, the peptidoglycan, cytoplasmic membrane, and protoplasmic components. The low abundance of lipopolysaccharides and transmembrane proteins enable it to conceal itself and to exert robust capabilities for tissue invasion and immune escape. Adhesion-mediated colonization plays a significant role in the pathogenesis of syphilis caused by Tp. In vitro studies have shown that Tp can adhere to cells of humans and other mammals, with a preference for interacting with specific molecules on certain cell surfaces, thereby influencing the invasion, pathogenicity and immune escape of Tp. This review summarizes how adhesion proteins of Tp interact with various host cells to trigger invasion and infection, and overviews their role in syphilis pathogenesis, aiming to offer significant insights for research into etiology, vaccine development, and the discovery of novel therapeutic agents for syphilis. |
| format | Article |
| id | doaj-art-390d42835d4345ffb6eccf8e64724bab |
| institution | DOAJ |
| issn | 1674-8468 |
| language | zho |
| publishDate | 2025-03-01 |
| publisher | editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology |
| record_format | Article |
| series | Pifu-xingbing zhenliaoxue zazhi |
| spelling | doaj-art-390d42835d4345ffb6eccf8e64724bab2025-08-20T03:18:09Zzhoeditoiral office of Journal of Diagnosis and Therapy on Dermato-venereologyPifu-xingbing zhenliaoxue zazhi1674-84682025-03-0132321522110.3969/j.issn.1674-8468.2025.03.010Research progress on the interactions between Treponema pallidum adhesion proteins and host cellsHUANG Jialin0ZHENG Judun1Dermatology Hospital, Southern Medical University, Guangzhou 510091, ChinaDermatology Hospital, Southern Medical University, Guangzhou 510091, ChinaTreponema pallidum (Tp) has an outer membrane that encircles the periplasmic space, the peptidoglycan, cytoplasmic membrane, and protoplasmic components. The low abundance of lipopolysaccharides and transmembrane proteins enable it to conceal itself and to exert robust capabilities for tissue invasion and immune escape. Adhesion-mediated colonization plays a significant role in the pathogenesis of syphilis caused by Tp. In vitro studies have shown that Tp can adhere to cells of humans and other mammals, with a preference for interacting with specific molecules on certain cell surfaces, thereby influencing the invasion, pathogenicity and immune escape of Tp. This review summarizes how adhesion proteins of Tp interact with various host cells to trigger invasion and infection, and overviews their role in syphilis pathogenesis, aiming to offer significant insights for research into etiology, vaccine development, and the discovery of novel therapeutic agents for syphilis.http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2025.03.010treponema pallidumadhesin proteinhost cells |
| spellingShingle | HUANG Jialin ZHENG Judun Research progress on the interactions between Treponema pallidum adhesion proteins and host cells Pifu-xingbing zhenliaoxue zazhi treponema pallidum adhesin protein host cells |
| title | Research progress on the interactions between Treponema pallidum adhesion proteins and host cells |
| title_full | Research progress on the interactions between Treponema pallidum adhesion proteins and host cells |
| title_fullStr | Research progress on the interactions between Treponema pallidum adhesion proteins and host cells |
| title_full_unstemmed | Research progress on the interactions between Treponema pallidum adhesion proteins and host cells |
| title_short | Research progress on the interactions between Treponema pallidum adhesion proteins and host cells |
| title_sort | research progress on the interactions between treponema pallidum adhesion proteins and host cells |
| topic | treponema pallidum adhesin protein host cells |
| url | http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2025.03.010 |
| work_keys_str_mv | AT huangjialin researchprogressontheinteractionsbetweentreponemapallidumadhesionproteinsandhostcells AT zhengjudun researchprogressontheinteractionsbetweentreponemapallidumadhesionproteinsandhostcells |