Large-Scale Neuronal Network Dysfunction in Diabetic Retinopathy

Diabetic retinopathy (DR) patients are at an increased risk of cognitive decline and dementia. There is accumulating evidence that specific functional and structural architecture changes in the brain are related to cognitive impairment in DR patients. However, little is known regarding whether the f...

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Main Authors: Xin Huang, Yan Tong, Chen-Xing Qi, Han-Dong Dan, Qin-Qin Deng, Yin Shen
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Neural Plasticity
Online Access:http://dx.doi.org/10.1155/2020/6872508
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author Xin Huang
Yan Tong
Chen-Xing Qi
Han-Dong Dan
Qin-Qin Deng
Yin Shen
author_facet Xin Huang
Yan Tong
Chen-Xing Qi
Han-Dong Dan
Qin-Qin Deng
Yin Shen
author_sort Xin Huang
collection DOAJ
description Diabetic retinopathy (DR) patients are at an increased risk of cognitive decline and dementia. There is accumulating evidence that specific functional and structural architecture changes in the brain are related to cognitive impairment in DR patients. However, little is known regarding whether the functional architecture of resting-state networks (RSNs) changes in DR patients. The purpose of this study was to investigate the intranetwork functional connectivity (FC) and functional network connectivity (FNC) of RSN changes in DR patients using independent component analysis (ICA). Thirty-four DR patients (18 men and 16 women; mean age, 53.53±8.67 years) and 38 nondiabetic healthy controls (HCs) (15 men and 23 women; mean age, 48.63±11.83 years), closely matched for age, sex, and education, underwent resting-state magnetic resonance imaging scans. ICA was applied to extract the nine RSNs. Then, two-sample t-tests were conducted to investigate different intranetwork FCs within nine RSNs between the two groups. The FNC toolbox was used to assess interactions among RSNs. Pearson correlation analysis was conducted to explore the relationship between intranetwork FCs and clinical variables in the DR group. A receiver operating characteristic (ROC) curve was conducted to assess the ability of the intranetwork FCs of RSNs in discriminating between the two groups. Compared to the HC group, DR patients showed significant decreased intranetwork FCs within the basal ganglia network (BGN), visual network (VN), ventral default mode network (vDMN), right executive control network (rECN), salience network (SN), left executive control network (lECN), auditory network (AN), and dorsal default mode network (dDMN). In addition, FNC analysis showed increased VN-BGN, VN-vDMN, VN-dDMN, vDMN-lECN, SN-BGN, lECN-dDMN, and AN-BGN FNCs in the DR group, relative to the HC group. Furthermore, altered intranetwork FCs of RSNs were significantly correlated with the glycosylated hemoglobin (HbA1c) level in DR patients. A ROC curve showed that these specific intranetwork FCs of RSNs discriminated between the two groups with a high degree of sensitivity and specificity. Our study highlighted that DR patients had widespread deficits in both low-level perceptual and higher-order cognitive networks. Our results offer important insights into the neural mechanisms of visual loss and cognitive decline in DR patients.
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spelling doaj-art-390c32634afd440cb62464f9249496342025-02-03T05:54:26ZengWileyNeural Plasticity2090-59041687-54432020-01-01202010.1155/2020/68725086872508Large-Scale Neuronal Network Dysfunction in Diabetic RetinopathyXin Huang0Yan Tong1Chen-Xing Qi2Han-Dong Dan3Qin-Qin Deng4Yin Shen5Eye Center, Renmin Hospital of Wuhan University, Wuhan, 430060 Hubei, ChinaEye Center, Renmin Hospital of Wuhan University, Wuhan, 430060 Hubei, ChinaEye Center, Renmin Hospital of Wuhan University, Wuhan, 430060 Hubei, ChinaEye Center, Renmin Hospital of Wuhan University, Wuhan, 430060 Hubei, ChinaEye Center, Renmin Hospital of Wuhan University, Wuhan, 430060 Hubei, ChinaEye Center, Renmin Hospital of Wuhan University, Wuhan, 430060 Hubei, ChinaDiabetic retinopathy (DR) patients are at an increased risk of cognitive decline and dementia. There is accumulating evidence that specific functional and structural architecture changes in the brain are related to cognitive impairment in DR patients. However, little is known regarding whether the functional architecture of resting-state networks (RSNs) changes in DR patients. The purpose of this study was to investigate the intranetwork functional connectivity (FC) and functional network connectivity (FNC) of RSN changes in DR patients using independent component analysis (ICA). Thirty-four DR patients (18 men and 16 women; mean age, 53.53±8.67 years) and 38 nondiabetic healthy controls (HCs) (15 men and 23 women; mean age, 48.63±11.83 years), closely matched for age, sex, and education, underwent resting-state magnetic resonance imaging scans. ICA was applied to extract the nine RSNs. Then, two-sample t-tests were conducted to investigate different intranetwork FCs within nine RSNs between the two groups. The FNC toolbox was used to assess interactions among RSNs. Pearson correlation analysis was conducted to explore the relationship between intranetwork FCs and clinical variables in the DR group. A receiver operating characteristic (ROC) curve was conducted to assess the ability of the intranetwork FCs of RSNs in discriminating between the two groups. Compared to the HC group, DR patients showed significant decreased intranetwork FCs within the basal ganglia network (BGN), visual network (VN), ventral default mode network (vDMN), right executive control network (rECN), salience network (SN), left executive control network (lECN), auditory network (AN), and dorsal default mode network (dDMN). In addition, FNC analysis showed increased VN-BGN, VN-vDMN, VN-dDMN, vDMN-lECN, SN-BGN, lECN-dDMN, and AN-BGN FNCs in the DR group, relative to the HC group. Furthermore, altered intranetwork FCs of RSNs were significantly correlated with the glycosylated hemoglobin (HbA1c) level in DR patients. A ROC curve showed that these specific intranetwork FCs of RSNs discriminated between the two groups with a high degree of sensitivity and specificity. Our study highlighted that DR patients had widespread deficits in both low-level perceptual and higher-order cognitive networks. Our results offer important insights into the neural mechanisms of visual loss and cognitive decline in DR patients.http://dx.doi.org/10.1155/2020/6872508
spellingShingle Xin Huang
Yan Tong
Chen-Xing Qi
Han-Dong Dan
Qin-Qin Deng
Yin Shen
Large-Scale Neuronal Network Dysfunction in Diabetic Retinopathy
Neural Plasticity
title Large-Scale Neuronal Network Dysfunction in Diabetic Retinopathy
title_full Large-Scale Neuronal Network Dysfunction in Diabetic Retinopathy
title_fullStr Large-Scale Neuronal Network Dysfunction in Diabetic Retinopathy
title_full_unstemmed Large-Scale Neuronal Network Dysfunction in Diabetic Retinopathy
title_short Large-Scale Neuronal Network Dysfunction in Diabetic Retinopathy
title_sort large scale neuronal network dysfunction in diabetic retinopathy
url http://dx.doi.org/10.1155/2020/6872508
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AT chenxingqi largescaleneuronalnetworkdysfunctionindiabeticretinopathy
AT handongdan largescaleneuronalnetworkdysfunctionindiabeticretinopathy
AT qinqindeng largescaleneuronalnetworkdysfunctionindiabeticretinopathy
AT yinshen largescaleneuronalnetworkdysfunctionindiabeticretinopathy