In silico assessment on the binding interactions of phytochemicals from Medicago sativa leaves with myocardial infarction targets
Medicago sativa (alfalfa), a perennial medicinal herb, has been widely valued for its diverse therapeutic applications. This study investigated the phytochemical composition of M. sativa leaves using various solvent extraction methods, including methanol, ethanol, chloroform, ethyl acetate, and pet...
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| Format: | Article |
| Language: | English |
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Society of Land Measurements and Cadastre from Transylvania (SMTCT)
2025-06-01
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| Series: | Notulae Scientia Biologicae |
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| Online Access: | https://www.notulaebiologicae.ro/index.php/nsb/article/view/12380 |
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| author | Rengaraj GOMATHI Hariharan USHA Thoudam BHAIGYABATI Sanasam SUCHITRA Pandian PARTHIBAN |
| author_facet | Rengaraj GOMATHI Hariharan USHA Thoudam BHAIGYABATI Sanasam SUCHITRA Pandian PARTHIBAN |
| author_sort | Rengaraj GOMATHI |
| collection | DOAJ |
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Medicago sativa (alfalfa), a perennial medicinal herb, has been widely valued for its diverse therapeutic applications. This study investigated the phytochemical composition of M. sativa leaves using various solvent extraction methods, including methanol, ethanol, chloroform, ethyl acetate, and petroleum ether. Qualitative phytochemical screening revealed the presence of key bioactive constituents, which were further evaluated for their in vitro free radical scavenging potential. Additionally, in silico molecular docking studies were conducted to assess the interactions of these bioactive compounds with myocardial infarction-associated targets, including Myoglobin, Cyclooxygenase, and Coagulation Factor X. The results demonstrated that several phytochemicals exhibited significant binding affinities with these targets, underscoring their potential as lead compounds for the development of novel therapeutic agents against myocardial infarction. These findings emphasize the pharmacological significance of M. sativa and its potential for advancing cardiovascular health interventions.
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| format | Article |
| id | doaj-art-390a2047e8c8474fa9bee736a145d8a9 |
| institution | Kabale University |
| issn | 2067-3264 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Society of Land Measurements and Cadastre from Transylvania (SMTCT) |
| record_format | Article |
| series | Notulae Scientia Biologicae |
| spelling | doaj-art-390a2047e8c8474fa9bee736a145d8a92025-08-20T03:29:14ZengSociety of Land Measurements and Cadastre from Transylvania (SMTCT)Notulae Scientia Biologicae2067-32642025-06-0117210.55779/nsb17212380In silico assessment on the binding interactions of phytochemicals from Medicago sativa leaves with myocardial infarction targetsRengaraj GOMATHI0Hariharan USHA1Thoudam BHAIGYABATI2Sanasam SUCHITRA3Pandian PARTHIBAN4Holy Cross College, Department of Biochemistry, Trichy, Tamil NaduAvinashilingam Institute for Home Science and Higher Education for Women, Biotechnology and Bioinformatics, Department of Biochemistry, Coimbatore, Tamil NaduPravabati College, Department of Biotechnology, Mayang Imphal, ManipurPravabati College, Department of Biochemistry, Mayang Imphal, ManipurPRIST Deemed to be University, Centre for Environmental Engineering, Thanjavur, Tamil Nadu Medicago sativa (alfalfa), a perennial medicinal herb, has been widely valued for its diverse therapeutic applications. This study investigated the phytochemical composition of M. sativa leaves using various solvent extraction methods, including methanol, ethanol, chloroform, ethyl acetate, and petroleum ether. Qualitative phytochemical screening revealed the presence of key bioactive constituents, which were further evaluated for their in vitro free radical scavenging potential. Additionally, in silico molecular docking studies were conducted to assess the interactions of these bioactive compounds with myocardial infarction-associated targets, including Myoglobin, Cyclooxygenase, and Coagulation Factor X. The results demonstrated that several phytochemicals exhibited significant binding affinities with these targets, underscoring their potential as lead compounds for the development of novel therapeutic agents against myocardial infarction. These findings emphasize the pharmacological significance of M. sativa and its potential for advancing cardiovascular health interventions. https://www.notulaebiologicae.ro/index.php/nsb/article/view/12380in silico studiesMedicago sativa leavesmyocardial infarctionphytochemicalsphytotherapy |
| spellingShingle | Rengaraj GOMATHI Hariharan USHA Thoudam BHAIGYABATI Sanasam SUCHITRA Pandian PARTHIBAN In silico assessment on the binding interactions of phytochemicals from Medicago sativa leaves with myocardial infarction targets Notulae Scientia Biologicae in silico studies Medicago sativa leaves myocardial infarction phytochemicals phytotherapy |
| title | In silico assessment on the binding interactions of phytochemicals from Medicago sativa leaves with myocardial infarction targets |
| title_full | In silico assessment on the binding interactions of phytochemicals from Medicago sativa leaves with myocardial infarction targets |
| title_fullStr | In silico assessment on the binding interactions of phytochemicals from Medicago sativa leaves with myocardial infarction targets |
| title_full_unstemmed | In silico assessment on the binding interactions of phytochemicals from Medicago sativa leaves with myocardial infarction targets |
| title_short | In silico assessment on the binding interactions of phytochemicals from Medicago sativa leaves with myocardial infarction targets |
| title_sort | in silico assessment on the binding interactions of phytochemicals from medicago sativa leaves with myocardial infarction targets |
| topic | in silico studies Medicago sativa leaves myocardial infarction phytochemicals phytotherapy |
| url | https://www.notulaebiologicae.ro/index.php/nsb/article/view/12380 |
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