Study of Postprandial Lipaemia in Type 2 Diabetes Mellitus: Exenatide versus Liraglutide
Therapeutic approaches based on the actions of the incretin hormone GLP-1 have been widely established in the management of T2DM. Nevertheless, much less research has been aimed at elucidating the role of GLP-1 in lipid metabolism and in particular postprandial dyslipidemia. Exenatide and liraglutid...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2014/304032 |
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| author | Maria Voukali Irene Kastrinelli Sapfo Stragalinou Dimitra Tasiopoulou Pinelopi Paraskevopoulou Nicholas Katsilambros Alexandros Kokkinos Nicholas Tentolouris Ioannis Ioannidis |
| author_facet | Maria Voukali Irene Kastrinelli Sapfo Stragalinou Dimitra Tasiopoulou Pinelopi Paraskevopoulou Nicholas Katsilambros Alexandros Kokkinos Nicholas Tentolouris Ioannis Ioannidis |
| author_sort | Maria Voukali |
| collection | DOAJ |
| description | Therapeutic approaches based on the actions of the incretin hormone GLP-1 have been widely established in the management of T2DM. Nevertheless, much less research has been aimed at elucidating the role of GLP-1 in lipid metabolism and in particular postprandial dyslipidemia. Exenatide and liraglutide are two GLP-1 receptor agonists which are currently available as subcutaneously administered treatment for T2DM but their chronic effects on postprandial lipaemia have not been well investigated. The aim of this study is to examine the effect of treatment with either liraglutide or exenatide for two weeks on postprandial lipaemia in obese subjects with T2DM. This study was a single-center, two-armed, randomized, controlled 2-week prospective intervention trial in 20 subjects with T2DM. Patients were randomized to receive either liraglutide or exenatide treatment and underwent a standardized meal tolerance test early in the morning after 10 h fast at baseline (visit 1, beginning of treatment) and after a two-week treatment period (visit 2). Exenatide and liraglutide both appear to be equally effective in lowering postprandial lipaemia after the first administration and after a two-week treatment. The mechanisms which lead to this phenomenon, which seem to be independent of gastric emptying, are yet to be studied. |
| format | Article |
| id | doaj-art-3909c55b83094478be8e7988465cdd03 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-3909c55b83094478be8e7988465cdd032025-02-03T06:13:17ZengWileyJournal of Diabetes Research2314-67452314-67532014-01-01201410.1155/2014/304032304032Study of Postprandial Lipaemia in Type 2 Diabetes Mellitus: Exenatide versus LiraglutideMaria Voukali0Irene Kastrinelli1Sapfo Stragalinou2Dimitra Tasiopoulou3Pinelopi Paraskevopoulou4Nicholas Katsilambros5Alexandros Kokkinos6Nicholas Tentolouris7Ioannis Ioannidis8Diabetes and Obesity Center, Konstantopouleio Hospital, 3-5 Agias Olgas Street, Nea Ionia, 14233 Athens, GreeceBiochemistry Laboratory, Konstantopouleio Hospital, 3-5 Agias Olgas Street, Nea Ionia, 14233 Athens, GreeceBiochemistry Laboratory, Konstantopouleio Hospital, 3-5 Agias Olgas Street, Nea Ionia, 14233 Athens, GreeceDiabetes and Obesity Center, Konstantopouleio Hospital, 3-5 Agias Olgas Street, Nea Ionia, 14233 Athens, GreeceBiochemistry Laboratory, Konstantopouleio Hospital, 3-5 Agias Olgas Street, Nea Ionia, 14233 Athens, Greece1st Department of Propaedeutic and Internal Medicine, Laiko General Hospital, Athens University Medical School, 17 Agiou Thoma Street, 115 27 Athens, Greece1st Department of Propaedeutic and Internal Medicine, Laiko General Hospital, Athens University Medical School, 17 Agiou Thoma Street, 115 27 Athens, Greece1st Department of Propaedeutic and Internal Medicine, Laiko General Hospital, Athens University Medical School, 17 Agiou Thoma Street, 115 27 Athens, GreeceDiabetes and Obesity Center, Konstantopouleio Hospital, 3-5 Agias Olgas Street, Nea Ionia, 14233 Athens, GreeceTherapeutic approaches based on the actions of the incretin hormone GLP-1 have been widely established in the management of T2DM. Nevertheless, much less research has been aimed at elucidating the role of GLP-1 in lipid metabolism and in particular postprandial dyslipidemia. Exenatide and liraglutide are two GLP-1 receptor agonists which are currently available as subcutaneously administered treatment for T2DM but their chronic effects on postprandial lipaemia have not been well investigated. The aim of this study is to examine the effect of treatment with either liraglutide or exenatide for two weeks on postprandial lipaemia in obese subjects with T2DM. This study was a single-center, two-armed, randomized, controlled 2-week prospective intervention trial in 20 subjects with T2DM. Patients were randomized to receive either liraglutide or exenatide treatment and underwent a standardized meal tolerance test early in the morning after 10 h fast at baseline (visit 1, beginning of treatment) and after a two-week treatment period (visit 2). Exenatide and liraglutide both appear to be equally effective in lowering postprandial lipaemia after the first administration and after a two-week treatment. The mechanisms which lead to this phenomenon, which seem to be independent of gastric emptying, are yet to be studied.http://dx.doi.org/10.1155/2014/304032 |
| spellingShingle | Maria Voukali Irene Kastrinelli Sapfo Stragalinou Dimitra Tasiopoulou Pinelopi Paraskevopoulou Nicholas Katsilambros Alexandros Kokkinos Nicholas Tentolouris Ioannis Ioannidis Study of Postprandial Lipaemia in Type 2 Diabetes Mellitus: Exenatide versus Liraglutide Journal of Diabetes Research |
| title | Study of Postprandial Lipaemia in Type 2 Diabetes Mellitus: Exenatide versus Liraglutide |
| title_full | Study of Postprandial Lipaemia in Type 2 Diabetes Mellitus: Exenatide versus Liraglutide |
| title_fullStr | Study of Postprandial Lipaemia in Type 2 Diabetes Mellitus: Exenatide versus Liraglutide |
| title_full_unstemmed | Study of Postprandial Lipaemia in Type 2 Diabetes Mellitus: Exenatide versus Liraglutide |
| title_short | Study of Postprandial Lipaemia in Type 2 Diabetes Mellitus: Exenatide versus Liraglutide |
| title_sort | study of postprandial lipaemia in type 2 diabetes mellitus exenatide versus liraglutide |
| url | http://dx.doi.org/10.1155/2014/304032 |
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