A Luciferase-Based Approach for Functional Screening of 5′ and 3′ Untranslated Regions of the mRNA Component for mRNA Vaccines

A Luciferase-Based Approach for Functional Screening of 5′ and 3′ Untranslated Regions of the mRNA Component for mRNA Vaccines

<b>Background/Objectives</b>: The recent COVID-19 pandemic caused by SARS-CoV-2 infection has highlighted the need for protocols for rapid development of efficient screening methods to search for the optimal mRNA vaccine structures against mutable viral agents. The unmatched success of m...

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Main Authors: Maria Rubtsova, Yuliana Mokrushina, Dmitry Andreev, Maria Poteshnova, Nikita Shepelev, Mariya Koryagina, Ekaterina Moiseeva, Diana Malabuiok, Yury Prokopenko, Stanislav Terekhov, Aleksander Chernov, Elena Vodovozova, Ivan Smirnov, Olga Dontsova, Alexander Gabibov, Yury Rubtsov
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Vaccines
Subjects:
mRNA vaccine
translation
UTRs
secreted nanoluciferase
lipid nanoparticles
immunization
Online Access:https://www.mdpi.com/2076-393X/13/5/530
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