The Analgesic Effect of Morphine on Peripheral Opioid Receptors: An Experimental Research
Opioids represent one of the key pillars in postoperative pain management, but their use has been associated with a variety of serious side effects. Thus, it is crucial to investigate the timing and course of opioid administration in order to ensure a best efficacy to side-effect profile. The aim of...
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| Format: | Article |
| Language: | English |
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2024-10-01
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| Series: | The Journal of Critical Care Medicine |
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| Online Access: | https://doi.org/10.2478/jccm-2024-0042 |
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| author | Jafal Nader-Mugurel Stoleru Smaranda Zugravu Aurelian Orban Carmen Popescu Mihai Marin Ruxandra Cristina Fulga Ion-Gigel |
| author_facet | Jafal Nader-Mugurel Stoleru Smaranda Zugravu Aurelian Orban Carmen Popescu Mihai Marin Ruxandra Cristina Fulga Ion-Gigel |
| author_sort | Jafal Nader-Mugurel |
| collection | DOAJ |
| description | Opioids represent one of the key pillars in postoperative pain management, but their use has been associated with a variety of serious side effects. Thus, it is crucial to investigate the timing and course of opioid administration in order to ensure a best efficacy to side-effect profile. The aim of our article was to investigate the analgesic effects of locally administered morphine sulfate (intraplantar) in a carrageenan-induced inflammation model in rats. After carrageenan administration, the rats were divided into 10 equal groups and were injected with either morphine 5 mg/kg or 0.9% saline solution at different time intervals, depending on the assigned group. The analgesic effect was assessed through thermal stimulation. Our results showed that paw withdrawal time was significantly higher in rats treated with morphine compared to those in the control group 9.18 ± 3.38 compared to 5.14 ± 2.21 seconds, p=0.012). However, differences were more pronounced at certain time intervals post-carrageenan administration (at 180 minutes compared to 360 minutes, p=0.003 and at 180 minutes compare to 1440 minutes p<0.001), indicating that efficacy varies depending on the timing of treatment. In conclusion, our findings support the hypothesis that locally administered morphine may alleviate pain under inflammatory conditions and underscores the importance of considering treatment timing when evaluating the analgesic effect. |
| format | Article |
| id | doaj-art-39082b9551dc417fa37a4751949891e1 |
| institution | Kabale University |
| issn | 2393-1817 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Sciendo |
| record_format | Article |
| series | The Journal of Critical Care Medicine |
| spelling | doaj-art-39082b9551dc417fa37a4751949891e12025-02-10T13:25:54ZengSciendoThe Journal of Critical Care Medicine2393-18172024-10-0110433734410.2478/jccm-2024-0042The Analgesic Effect of Morphine on Peripheral Opioid Receptors: An Experimental ResearchJafal Nader-Mugurel0Stoleru Smaranda1Zugravu Aurelian2Orban Carmen3Popescu Mihai4Marin Ruxandra Cristina5Fulga Ion-Gigel6“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaOpioids represent one of the key pillars in postoperative pain management, but their use has been associated with a variety of serious side effects. Thus, it is crucial to investigate the timing and course of opioid administration in order to ensure a best efficacy to side-effect profile. The aim of our article was to investigate the analgesic effects of locally administered morphine sulfate (intraplantar) in a carrageenan-induced inflammation model in rats. After carrageenan administration, the rats were divided into 10 equal groups and were injected with either morphine 5 mg/kg or 0.9% saline solution at different time intervals, depending on the assigned group. The analgesic effect was assessed through thermal stimulation. Our results showed that paw withdrawal time was significantly higher in rats treated with morphine compared to those in the control group 9.18 ± 3.38 compared to 5.14 ± 2.21 seconds, p=0.012). However, differences were more pronounced at certain time intervals post-carrageenan administration (at 180 minutes compared to 360 minutes, p=0.003 and at 180 minutes compare to 1440 minutes p<0.001), indicating that efficacy varies depending on the timing of treatment. In conclusion, our findings support the hypothesis that locally administered morphine may alleviate pain under inflammatory conditions and underscores the importance of considering treatment timing when evaluating the analgesic effect.https://doi.org/10.2478/jccm-2024-0042morphinecarrageenananalgesic effectintraplantar administrationpaw inflammation |
| spellingShingle | Jafal Nader-Mugurel Stoleru Smaranda Zugravu Aurelian Orban Carmen Popescu Mihai Marin Ruxandra Cristina Fulga Ion-Gigel The Analgesic Effect of Morphine on Peripheral Opioid Receptors: An Experimental Research The Journal of Critical Care Medicine morphine carrageenan analgesic effect intraplantar administration paw inflammation |
| title | The Analgesic Effect of Morphine on Peripheral Opioid Receptors: An Experimental Research |
| title_full | The Analgesic Effect of Morphine on Peripheral Opioid Receptors: An Experimental Research |
| title_fullStr | The Analgesic Effect of Morphine on Peripheral Opioid Receptors: An Experimental Research |
| title_full_unstemmed | The Analgesic Effect of Morphine on Peripheral Opioid Receptors: An Experimental Research |
| title_short | The Analgesic Effect of Morphine on Peripheral Opioid Receptors: An Experimental Research |
| title_sort | analgesic effect of morphine on peripheral opioid receptors an experimental research |
| topic | morphine carrageenan analgesic effect intraplantar administration paw inflammation |
| url | https://doi.org/10.2478/jccm-2024-0042 |
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