Genome-wide CRISPR screen for human factors involved in alternative polyadenylation based on differential localization of CD47

Genome-wide CRISPR screen for human factors involved in alternative polyadenylation based on differential localization of CD47

Abstract At least 70% of the human protein-coding genes contain multiple polyadenylation sites (PAS) and undergo alternative polyadenylation (APA), generating distinct transcripts from a single gene. While APA has been implicated in various physiological and pathological processes, its regulatory fa...

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Bibliographic Details
Main Authors: Chayanin Wuttinontananchai, Junichi Yamamoto, Satoshi Sakamoto, Yuki Yamaguchi
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Genome-wide CRISPR screen
Alternative polyadenylation
CD47
POLDIP2
RNA-seq
Online Access:https://doi.org/10.1038/s41598-025-14782-7
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