Gastric cancer-derived exosomal let-7 g-5p mediated by SERPINE1 promotes macrophage M2 polarization and gastric cancer progression
Highlights SERPINE1 mediates the transfer of cancer-derived exosomal let-7 g-5p to promote macrophage M2 polarization. Exosomal let-7 g-5p drives M2 polarization by downregulating SOCS7 and relieving its inhibition of STAT3 phosphorylation. SERPINE1 promotes the transcription of let-7 g-5p by activa...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13046-024-03269-4 |
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| _version_ | 1841559005195927552 |
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| author | Zhenzhen Ye Jianfeng Yi Xiangyan Jiang Wengui Shi Hao Xu Hongtai Cao Long Qin Lixin Liu Tianming Wang Zhijian Ma Zuoyi Jiao |
| author_facet | Zhenzhen Ye Jianfeng Yi Xiangyan Jiang Wengui Shi Hao Xu Hongtai Cao Long Qin Lixin Liu Tianming Wang Zhijian Ma Zuoyi Jiao |
| author_sort | Zhenzhen Ye |
| collection | DOAJ |
| description | Highlights SERPINE1 mediates the transfer of cancer-derived exosomal let-7 g-5p to promote macrophage M2 polarization. Exosomal let-7 g-5p drives M2 polarization by downregulating SOCS7 and relieving its inhibition of STAT3 phosphorylation. SERPINE1 promotes the transcription of let-7 g-5p by activating the JAK2/STAT3 signaling pathway. |
| format | Article |
| id | doaj-art-39029d9005354e81ab647c6edc40694f |
| institution | Kabale University |
| issn | 1756-9966 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj-art-39029d9005354e81ab647c6edc40694f2025-01-05T12:50:01ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662025-01-0144112110.1186/s13046-024-03269-4Gastric cancer-derived exosomal let-7 g-5p mediated by SERPINE1 promotes macrophage M2 polarization and gastric cancer progressionZhenzhen Ye0Jianfeng Yi1Xiangyan Jiang2Wengui Shi3Hao Xu4Hongtai Cao5Long Qin6Lixin Liu7Tianming Wang8Zhijian Ma9Zuoyi Jiao10Department of General Surgery, The Second Clinical Medical School, The Second Hospital of Lanzhou University, Lanzhou UniversityThe First School of Clinical Medicine, Gansu University of Chinese MedicineDepartment of General Surgery, The Second Clinical Medical School, The Second Hospital of Lanzhou University, Lanzhou UniversityDepartment of General Surgery, The Second Clinical Medical School, The Second Hospital of Lanzhou University, Lanzhou UniversityDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Provincial Hospital of Chinese MedicineDepartment of General Surgery, The Second Clinical Medical School, The Second Hospital of Lanzhou University, Lanzhou UniversityDepartment of General Surgery, The Second Clinical Medical School, The Second Hospital of Lanzhou University, Lanzhou UniversityDepartment of General Surgery, The Second Clinical Medical School, The Second Hospital of Lanzhou University, Lanzhou UniversityThe First School of Clinical Medicine, Gansu University of Chinese MedicineDepartment of General Surgery, The Second Clinical Medical School, The Second Hospital of Lanzhou University, Lanzhou UniversityDepartment of General Surgery, The Second Clinical Medical School, The Second Hospital of Lanzhou University, Lanzhou UniversityHighlights SERPINE1 mediates the transfer of cancer-derived exosomal let-7 g-5p to promote macrophage M2 polarization. Exosomal let-7 g-5p drives M2 polarization by downregulating SOCS7 and relieving its inhibition of STAT3 phosphorylation. SERPINE1 promotes the transcription of let-7 g-5p by activating the JAK2/STAT3 signaling pathway.https://doi.org/10.1186/s13046-024-03269-4Gastric cancerSERPINE1/PAI-1let-7 g-5pCancer-derived exosomeM2 polarization |
| spellingShingle | Zhenzhen Ye Jianfeng Yi Xiangyan Jiang Wengui Shi Hao Xu Hongtai Cao Long Qin Lixin Liu Tianming Wang Zhijian Ma Zuoyi Jiao Gastric cancer-derived exosomal let-7 g-5p mediated by SERPINE1 promotes macrophage M2 polarization and gastric cancer progression Journal of Experimental & Clinical Cancer Research Gastric cancer SERPINE1/PAI-1 let-7 g-5p Cancer-derived exosome M2 polarization |
| title | Gastric cancer-derived exosomal let-7 g-5p mediated by SERPINE1 promotes macrophage M2 polarization and gastric cancer progression |
| title_full | Gastric cancer-derived exosomal let-7 g-5p mediated by SERPINE1 promotes macrophage M2 polarization and gastric cancer progression |
| title_fullStr | Gastric cancer-derived exosomal let-7 g-5p mediated by SERPINE1 promotes macrophage M2 polarization and gastric cancer progression |
| title_full_unstemmed | Gastric cancer-derived exosomal let-7 g-5p mediated by SERPINE1 promotes macrophage M2 polarization and gastric cancer progression |
| title_short | Gastric cancer-derived exosomal let-7 g-5p mediated by SERPINE1 promotes macrophage M2 polarization and gastric cancer progression |
| title_sort | gastric cancer derived exosomal let 7 g 5p mediated by serpine1 promotes macrophage m2 polarization and gastric cancer progression |
| topic | Gastric cancer SERPINE1/PAI-1 let-7 g-5p Cancer-derived exosome M2 polarization |
| url | https://doi.org/10.1186/s13046-024-03269-4 |
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