Phosphopenic form of osteomalacia in a patient with FGF23 producing tumor
Oncogenic osteomalacia is an orphan disease caused by the overproduction of fibroblast growth factor 23 (FGF23) in tumors, which leads to impaired bone matrix mineralization. Typical laboratory changes are hypophosphatemia, increased alkaline phosphatase, hyperphosphaturia, and decreased tubular pho...
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2022-05-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/3159 |
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| author | A. S. Pushkareva E. E. Bibik A. K. Eremkina M. V. Degtyarev N. G. Mokrysheva |
| author_facet | A. S. Pushkareva E. E. Bibik A. K. Eremkina M. V. Degtyarev N. G. Mokrysheva |
| author_sort | A. S. Pushkareva |
| collection | DOAJ |
| description | Oncogenic osteomalacia is an orphan disease caused by the overproduction of fibroblast growth factor 23 (FGF23) in tumors, which leads to impaired bone matrix mineralization. Typical laboratory changes are hypophosphatemia, increased alkaline phosphatase, hyperphosphaturia, and decreased tubular phosphate reabsorption index. Surgery is the treatment of choice to eliminate an excessive production of FGF23. If surgical intervention is ineffective or impossible, preparations of phosphorus, calcium, vitamin D are prescribed. We present a clinical case of the stage-bystage diagnosis and treatment of the patient with chronic pain syndrome in the bones and multiple fractures. |
| format | Article |
| id | doaj-art-38fccddf42f84a5fad01b836d60fe95d |
| institution | DOAJ |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| publishDate | 2022-05-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj-art-38fccddf42f84a5fad01b836d60fe95d2025-08-20T02:55:20ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922022-05-0160224925510.47360/1995-4484-2022-249-2552803Phosphopenic form of osteomalacia in a patient with FGF23 producing tumorA. S. Pushkareva0E. E. Bibik1A. K. Eremkina2M. V. Degtyarev3N. G. Mokrysheva4The National Medical Research Center for EndocrinologyThe National Medical Research Center for EndocrinologyThe National Medical Research Center for EndocrinologyThe National Medical Research Center for EndocrinologyThe National Medical Research Center for EndocrinologyOncogenic osteomalacia is an orphan disease caused by the overproduction of fibroblast growth factor 23 (FGF23) in tumors, which leads to impaired bone matrix mineralization. Typical laboratory changes are hypophosphatemia, increased alkaline phosphatase, hyperphosphaturia, and decreased tubular phosphate reabsorption index. Surgery is the treatment of choice to eliminate an excessive production of FGF23. If surgical intervention is ineffective or impossible, preparations of phosphorus, calcium, vitamin D are prescribed. We present a clinical case of the stage-bystage diagnosis and treatment of the patient with chronic pain syndrome in the bones and multiple fractures.https://rsp.mediar-press.net/rsp/article/view/3159osteomalaciatumorhypophosphatemiafracturefgf23 |
| spellingShingle | A. S. Pushkareva E. E. Bibik A. K. Eremkina M. V. Degtyarev N. G. Mokrysheva Phosphopenic form of osteomalacia in a patient with FGF23 producing tumor Научно-практическая ревматология osteomalacia tumor hypophosphatemia fracture fgf23 |
| title | Phosphopenic form of osteomalacia in a patient with FGF23 producing tumor |
| title_full | Phosphopenic form of osteomalacia in a patient with FGF23 producing tumor |
| title_fullStr | Phosphopenic form of osteomalacia in a patient with FGF23 producing tumor |
| title_full_unstemmed | Phosphopenic form of osteomalacia in a patient with FGF23 producing tumor |
| title_short | Phosphopenic form of osteomalacia in a patient with FGF23 producing tumor |
| title_sort | phosphopenic form of osteomalacia in a patient with fgf23 producing tumor |
| topic | osteomalacia tumor hypophosphatemia fracture fgf23 |
| url | https://rsp.mediar-press.net/rsp/article/view/3159 |
| work_keys_str_mv | AT aspushkareva phosphopenicformofosteomalaciainapatientwithfgf23producingtumor AT eebibik phosphopenicformofosteomalaciainapatientwithfgf23producingtumor AT akeremkina phosphopenicformofosteomalaciainapatientwithfgf23producingtumor AT mvdegtyarev phosphopenicformofosteomalaciainapatientwithfgf23producingtumor AT ngmokrysheva phosphopenicformofosteomalaciainapatientwithfgf23producingtumor |