Difluprednate: An Overview
The mainstay in the treatment of ocular inflammation, either post-surgical or endogenous, is the use of steroids. While these agents effectively address inflammation, they are not without their risks, including ocular hypertension and acceleration of cataract formation. The most notorious culprits a...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | Delhi Journal of Ophthalmology |
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| Online Access: | https://journals.lww.com/10.7869/djo.2012.63 |
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| author | Charu Mithal Shilpa Singh Sonali Gupta Sandeep Mithal |
| author_facet | Charu Mithal Shilpa Singh Sonali Gupta Sandeep Mithal |
| author_sort | Charu Mithal |
| collection | DOAJ |
| description | The mainstay in the treatment of ocular inflammation, either post-surgical or endogenous, is the use of steroids. While these agents effectively address inflammation, they are not without their risks, including ocular hypertension and acceleration of cataract formation. The most notorious culprits are the strong steroids, such as prednisolone acetate and betamethasone. This review aims to cover the biochemistry and drug development of difluprednate, a novel synthetic strong steroid emulsion. In vivo pharmacokinetics as well as ocular distribution and metabolism are discussed, followed by a comprehensive summary of phase I, II, and III clinical trials evaluating safety and efficacy in patients suffering from postoperative inflammation, posterior segment inflammation or anterior uveitis. |
| format | Article |
| id | doaj-art-38f7a2d9aac34fd180d5afabcb010ae6 |
| institution | Kabale University |
| issn | 0972-0200 2454-2784 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Delhi Journal of Ophthalmology |
| spelling | doaj-art-38f7a2d9aac34fd180d5afabcb010ae62025-08-20T03:52:29ZengWolters Kluwer Medknow PublicationsDelhi Journal of Ophthalmology0972-02002454-27842013-01-0123316516810.7869/djo.2012.63Difluprednate: An OverviewCharu MithalShilpa SinghSonali GuptaSandeep MithalThe mainstay in the treatment of ocular inflammation, either post-surgical or endogenous, is the use of steroids. While these agents effectively address inflammation, they are not without their risks, including ocular hypertension and acceleration of cataract formation. The most notorious culprits are the strong steroids, such as prednisolone acetate and betamethasone. This review aims to cover the biochemistry and drug development of difluprednate, a novel synthetic strong steroid emulsion. In vivo pharmacokinetics as well as ocular distribution and metabolism are discussed, followed by a comprehensive summary of phase I, II, and III clinical trials evaluating safety and efficacy in patients suffering from postoperative inflammation, posterior segment inflammation or anterior uveitis.https://journals.lww.com/10.7869/djo.2012.63difluprednatesteroidemulsionophthalmic surgery. |
| spellingShingle | Charu Mithal Shilpa Singh Sonali Gupta Sandeep Mithal Difluprednate: An Overview Delhi Journal of Ophthalmology difluprednate steroid emulsion ophthalmic surgery. |
| title | Difluprednate: An Overview |
| title_full | Difluprednate: An Overview |
| title_fullStr | Difluprednate: An Overview |
| title_full_unstemmed | Difluprednate: An Overview |
| title_short | Difluprednate: An Overview |
| title_sort | difluprednate an overview |
| topic | difluprednate steroid emulsion ophthalmic surgery. |
| url | https://journals.lww.com/10.7869/djo.2012.63 |
| work_keys_str_mv | AT charumithal difluprednateanoverview AT shilpasingh difluprednateanoverview AT sonaligupta difluprednateanoverview AT sandeepmithal difluprednateanoverview |