Mechanisms of isorhamnetin inhibition of osteoclast differentiation: insights from molecular dynamics simulations and in vitro/in vivo experiments

Mechanisms of isorhamnetin inhibition of osteoclast differentiation: insights from molecular dynamics simulations and in vitro/in vivo experiments

BackgroundOsteoporosis (OP) represents a widespread bone remodeling disorder within the domain of orthopedics, markedly compromising the quality of life in the elderly population. The need to develop more efficient therapeutic approaches to attenuate bone resorption by suppressing the excessive acti...

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Bibliographic Details
Main Authors: Yi Zhou, Shaoshuo Li, Bowen Hong, Zihan Wang, Yang Shao, Mao Wu, Jianwei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
isorhamnetin
molecular dynamics simulation
network pharmacology
osteoclast
osteoporosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1551257/full
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