Differences in the distribution of HER2-positive breast tumors according to ethnicity and genetic variants in ERBB2: a special focus on Asian and Latina women
BackgroundHER2-positive breast tumors are clinically important breast cancer subtypes with an overall unfavorable prognosis, but also with current optimal treatment options that have significantly improved the patients’ survival. Several epidemiological registries have reported varying prevalence ra...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1635681/full |
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| author | Laura Rey-Vargas Laura Rey-Vargas Lina María Bejarano-Rivera Patricia López-Correa Diego Felipe Ballen-Lozano Silvia J. Serrano-Gómez Silvia J. Serrano-Gómez |
| author_facet | Laura Rey-Vargas Laura Rey-Vargas Lina María Bejarano-Rivera Patricia López-Correa Diego Felipe Ballen-Lozano Silvia J. Serrano-Gómez Silvia J. Serrano-Gómez |
| author_sort | Laura Rey-Vargas |
| collection | DOAJ |
| description | BackgroundHER2-positive breast tumors are clinically important breast cancer subtypes with an overall unfavorable prognosis, but also with current optimal treatment options that have significantly improved the patients’ survival. Several epidemiological registries have reported varying prevalence rates of HER2-positive breast tumors among population groups. In this review, we describe the prevalence of HER2-positive breast tumors by ethnicity, with a special focus on Asian and Latina women, along with genetic variants located in or near ERBB2 that might affect its protein expression.MethodsWe conducted a literature search for studies reporting differences in HER2-positive breast tumor prevalence among populations and HER2/ERBB2 molecular features based on genomic background or ancestry.ResultsOverall, Asian and Latina women tend to have higher proportions of HER2-amplified tumors, compared to non-Hispanic white (NHW) women. Additionally, higher Indigenous American ancestry is associated with an increased likelihood of HER2-positive tumors and elevated ERBB2 expression. We also describe reported differences in the genotype of several genetic variants in ERBB2 or nearby genomic regions according to HER2 expression, and mention variants in other genes that may also be associated.ConclusionsThis literature review contributes to a better understanding of the underlying biology of HER2 expression in breast tumors, and the possible mechanisms that explain the differences in the distribution of HER2-positive subtypes among various population groups. |
| format | Article |
| id | doaj-art-38f16edd438f4e62b061fa7e69e1e14b |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-38f16edd438f4e62b061fa7e69e1e14b2025-08-20T03:32:20ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-07-011510.3389/fonc.2025.16356811635681Differences in the distribution of HER2-positive breast tumors according to ethnicity and genetic variants in ERBB2: a special focus on Asian and Latina womenLaura Rey-Vargas0Laura Rey-Vargas1Lina María Bejarano-Rivera2Patricia López-Correa3Diego Felipe Ballen-Lozano4Silvia J. Serrano-Gómez5Silvia J. Serrano-Gómez6Cancer Biology Research Group, National Cancer Institute, Bogotá, ColombiaDoctoral Program in Biological Sciences, Pontificia Universidad Javeriana, Bogotá, ColombiaCancer Biology Research Group, National Cancer Institute, Bogotá, ColombiaDepartment of Pathology, National Cancer Institute, Bogotá, ColombiaClinical Oncology Unit, National Cancer Institute, Bogotá, ColombiaCancer Biology Research Group, National Cancer Institute, Bogotá, ColombiaResearch Support and Follow-Up Group, National Cancer Institute, Bogotá, ColombiaBackgroundHER2-positive breast tumors are clinically important breast cancer subtypes with an overall unfavorable prognosis, but also with current optimal treatment options that have significantly improved the patients’ survival. Several epidemiological registries have reported varying prevalence rates of HER2-positive breast tumors among population groups. In this review, we describe the prevalence of HER2-positive breast tumors by ethnicity, with a special focus on Asian and Latina women, along with genetic variants located in or near ERBB2 that might affect its protein expression.MethodsWe conducted a literature search for studies reporting differences in HER2-positive breast tumor prevalence among populations and HER2/ERBB2 molecular features based on genomic background or ancestry.ResultsOverall, Asian and Latina women tend to have higher proportions of HER2-amplified tumors, compared to non-Hispanic white (NHW) women. Additionally, higher Indigenous American ancestry is associated with an increased likelihood of HER2-positive tumors and elevated ERBB2 expression. We also describe reported differences in the genotype of several genetic variants in ERBB2 or nearby genomic regions according to HER2 expression, and mention variants in other genes that may also be associated.ConclusionsThis literature review contributes to a better understanding of the underlying biology of HER2 expression in breast tumors, and the possible mechanisms that explain the differences in the distribution of HER2-positive subtypes among various population groups.https://www.frontiersin.org/articles/10.3389/fonc.2025.1635681/fullbreast neoplasmsHER2 geneAmerican Native Continental Ancestrysingle nucleoside polymorphismethnic group |
| spellingShingle | Laura Rey-Vargas Laura Rey-Vargas Lina María Bejarano-Rivera Patricia López-Correa Diego Felipe Ballen-Lozano Silvia J. Serrano-Gómez Silvia J. Serrano-Gómez Differences in the distribution of HER2-positive breast tumors according to ethnicity and genetic variants in ERBB2: a special focus on Asian and Latina women Frontiers in Oncology breast neoplasms HER2 gene American Native Continental Ancestry single nucleoside polymorphism ethnic group |
| title | Differences in the distribution of HER2-positive breast tumors according to ethnicity and genetic variants in ERBB2: a special focus on Asian and Latina women |
| title_full | Differences in the distribution of HER2-positive breast tumors according to ethnicity and genetic variants in ERBB2: a special focus on Asian and Latina women |
| title_fullStr | Differences in the distribution of HER2-positive breast tumors according to ethnicity and genetic variants in ERBB2: a special focus on Asian and Latina women |
| title_full_unstemmed | Differences in the distribution of HER2-positive breast tumors according to ethnicity and genetic variants in ERBB2: a special focus on Asian and Latina women |
| title_short | Differences in the distribution of HER2-positive breast tumors according to ethnicity and genetic variants in ERBB2: a special focus on Asian and Latina women |
| title_sort | differences in the distribution of her2 positive breast tumors according to ethnicity and genetic variants in erbb2 a special focus on asian and latina women |
| topic | breast neoplasms HER2 gene American Native Continental Ancestry single nucleoside polymorphism ethnic group |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1635681/full |
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